The synthesis of a novel water-soluble Pt(0) complex [Pt(1-gluAc)(dmf)] containing a glucoconjugated 2-iminopyridine ligand and dimethylfumarate is reported. Highly diastereoselectivity leads to the prevalent formation of only one of the possible diasteroisomers, which has been characterized by mono- and bi-dimensional NMR techniques. The anticancer activity of the complex was evaluated against two couples of cell lines, and the IC50 values reveal that it is more cytotoxic than cisplatin but no selective toward cancer cells.
A hydrophilic olefin Pt(0) complex containing a glucoconjugated 2-iminopyridine ligand: Synthesis, characterization, stereochemistry and biological activity / Annunziata, A.; Cucciolito, M. E.; Imbimbo, P.; Silipo, A.; Ruffo, F.. - In: INORGANICA CHIMICA ACTA. - ISSN 0020-1693. - 516:120092(2021), pp. 1-6. [10.1016/j.ica.2020.120092]
A hydrophilic olefin Pt(0) complex containing a glucoconjugated 2-iminopyridine ligand: Synthesis, characterization, stereochemistry and biological activity
Annunziata A.;Cucciolito M. E.;Imbimbo P.;Silipo A.;Ruffo F.
2021
Abstract
The synthesis of a novel water-soluble Pt(0) complex [Pt(1-gluAc)(dmf)] containing a glucoconjugated 2-iminopyridine ligand and dimethylfumarate is reported. Highly diastereoselectivity leads to the prevalent formation of only one of the possible diasteroisomers, which has been characterized by mono- and bi-dimensional NMR techniques. The anticancer activity of the complex was evaluated against two couples of cell lines, and the IC50 values reveal that it is more cytotoxic than cisplatin but no selective toward cancer cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
