Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p<0.001 and p<0.003) along with a marked increase of the mDC/pDC ratio (p<0.001). Analysis of peripheral lymphocyte subsets showed that the naive/memory T cell ratio was significantly reduced in COPD patients in comparison with never smokers (p<0.001). Similar perturbations in the distribution of DCs and T cells also occurred in control smokers. This study is the first report of an imbalance of blood DCs in COPD. Influence of smoking and clinical relevance of these findings are discussed. © 2010 Elsevier Inc.

Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease / Galgani, M.; Fabozzi, I.; Perna, F.; Bruzzese, D.; Bellofiore, B.; Calabrese, C.; Vatrella, A.; Galati, D.; Matarese, G.; Sanduzzi, A.; Bocchino, M.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 137:1(2010), pp. 102-110. [10.1016/j.clim.2010.06.010]

Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease

Galgani M.;Perna F.;Bruzzese D.;Bellofiore B.;Vatrella A.;Matarese G.;Bocchino M.
2010

Abstract

Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p<0.001 and p<0.003) along with a marked increase of the mDC/pDC ratio (p<0.001). Analysis of peripheral lymphocyte subsets showed that the naive/memory T cell ratio was significantly reduced in COPD patients in comparison with never smokers (p<0.001). Similar perturbations in the distribution of DCs and T cells also occurred in control smokers. This study is the first report of an imbalance of blood DCs in COPD. Influence of smoking and clinical relevance of these findings are discussed. © 2010 Elsevier Inc.
2010
Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease / Galgani, M.; Fabozzi, I.; Perna, F.; Bruzzese, D.; Bellofiore, B.; Calabrese, C.; Vatrella, A.; Galati, D.; Matarese, G.; Sanduzzi, A.; Bocchino, M.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 137:1(2010), pp. 102-110. [10.1016/j.clim.2010.06.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/832466
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