The design of novel metal complexes with N-heterocyclic carbene (NHC) ligands that display biological activity is an active research field in organometallic chemistry. One of the possible approaches consists of the use of NHC ligands functionalized with a carbohydrate moiety. Two novel Au(I)-Au(I) dinuclear complexes were synthesized; they present a neutral structure with one bridging diNHC ligand, having one or both heterocyclic rings decorated with a carbohydrate functionality. With the symmetric diNHC ligand, the dicationic dinuclear complex bearing two bridging diNHC ligands was also synthesized. The study was completed by analyzing the antiproliferative properties of these complexes, which were compared to the activity displayed by similar mononuclear Au(I) complexes and by the analogous bimetallic Au(I)-Au(I) complex not functionalized with carbohydrates.

Synthesis and biological studies on dinuclear gold(I) complexes with Di-(N-Heterocyclic Carbene) ligands functionalized with carbohydrates / Tresin, F.; Stoppa, V.; Baron, M.; Biffis, A.; Annunziata, A.; D'Elia, L.; Monti, D. M.; Ruffo, F.; Roverso, M.; Sgarbossa, P.; Bogialli, S.; Tubaro, C.. - In: MOLECULES. - ISSN 1420-3049. - 25:17(2020), p. 3850. [10.3390/molecules25173850]

Synthesis and biological studies on dinuclear gold(I) complexes with Di-(N-Heterocyclic Carbene) ligands functionalized with carbohydrates

Annunziata A.;D'Elia L.;Monti D. M.;Ruffo F.;
2020

Abstract

The design of novel metal complexes with N-heterocyclic carbene (NHC) ligands that display biological activity is an active research field in organometallic chemistry. One of the possible approaches consists of the use of NHC ligands functionalized with a carbohydrate moiety. Two novel Au(I)-Au(I) dinuclear complexes were synthesized; they present a neutral structure with one bridging diNHC ligand, having one or both heterocyclic rings decorated with a carbohydrate functionality. With the symmetric diNHC ligand, the dicationic dinuclear complex bearing two bridging diNHC ligands was also synthesized. The study was completed by analyzing the antiproliferative properties of these complexes, which were compared to the activity displayed by similar mononuclear Au(I) complexes and by the analogous bimetallic Au(I)-Au(I) complex not functionalized with carbohydrates.
2020
Synthesis and biological studies on dinuclear gold(I) complexes with Di-(N-Heterocyclic Carbene) ligands functionalized with carbohydrates / Tresin, F.; Stoppa, V.; Baron, M.; Biffis, A.; Annunziata, A.; D'Elia, L.; Monti, D. M.; Ruffo, F.; Roverso, M.; Sgarbossa, P.; Bogialli, S.; Tubaro, C.. - In: MOLECULES. - ISSN 1420-3049. - 25:17(2020), p. 3850. [10.3390/molecules25173850]
File in questo prodotto:
File Dimensione Formato  
Tresin Molecules 2020.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Dominio pubblico
Dimensione 1.95 MB
Formato Adobe PDF
1.95 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/833847
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact