Effects of an oral supplement based on cucurbita maxima and capsicum annum on symptoms of overactive bladder in female population: an observational study

Introduction: The prevalence of overactive bladder (OAB) in women increases with age and is present in approximately 30 % of women over the age of 65 years. A high percentage of patients undergoing pharmacological therapy discontinue treatment for side effects and costs. Using an oral supplement (Kubiker®), consisting of vitamins, cucurbita maxima, capsicum annum, polygonum cuspidatum and L-Glutammin, for the control of urinary symptoms, could be a valid alternative. Objective: To assess the efficacy and tolerability of this oral supplement in women affected by OAB. Methods: We performed a retrospective, longitudinal, observational, cohort study of 84 patients affected by OAB, who received a prescription of Kubiker® for 12 weeks (2 tablets a day for the first month, then 1 tablet a day for 2 months). Primary outcome was to check the efficacy of therapy through questionnaire Patient global impression of improvement (PGI-I) after 12 weeks of therapy. The secondary outcome was to evaluate the difference in the answers of the Overactive Bladder Questionnaire (OAB-Q) before and after therapy. Adherence to therapy was also evaluated. Results: Data showed a positive effect of Kubiker® in the control of urinary symptoms after 12 weeks of therapy. Paired t-test used for the evaluation of OBS before and after the treatment showed a p-value < 0.001. The analysis of this questionnaire especially showed an improvement in the responses concerning the symptoms of urination urgency and urge incontinence. Conclusion: Therapy with oral supplement based on vitamins (C and D), cucurbita maxima, capsicum annum, polygonum cuspidatum and L-Glutammin is an effective and well-tolerated treatment for overactive bladder.