Fetal aneuploidies are among the most common causes of miscarriages, perinatal mortality and neurodevelopmental impairment. During the last 70 years, many efforts have been made in order to improve prenatal diagnosis and prenatal screening of these conditions. Recently, the use of cell-free fetal DNA (cff-DNA) testing has been increasingly used in different countries, representing an opportunity for non-invasive prenatal screening of pregnant women. The aim of this narrative review is to describe the state of the art and the main strengths and limitations of this test for prenatal screening of fetal aneuploidies.
Non-invasive prenatal testing: Current perspectives and future challenges / Carbone, L.; Cariati, F.; Sarno, L.; Conforti, A.; Bagnulo, F.; Strina, I.; Pastore, L.; Maruotti, G. M.; Alviggi, C.. - In: GENES. - ISSN 2073-4425. - 12:1(2021), pp. 1-12. [10.3390/genes12010015]
Non-invasive prenatal testing: Current perspectives and future challenges
Carbone L.;Cariati F.;Sarno L.;Conforti A.;Strina I.;Pastore L.;Maruotti G. M.;Alviggi C.
2021
Abstract
Fetal aneuploidies are among the most common causes of miscarriages, perinatal mortality and neurodevelopmental impairment. During the last 70 years, many efforts have been made in order to improve prenatal diagnosis and prenatal screening of these conditions. Recently, the use of cell-free fetal DNA (cff-DNA) testing has been increasingly used in different countries, representing an opportunity for non-invasive prenatal screening of pregnant women. The aim of this narrative review is to describe the state of the art and the main strengths and limitations of this test for prenatal screening of fetal aneuploidies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
