Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents- and allow ready preparation of the final compound in moderate- overall yields. Most of the synthetic steps proposed were microwave assisted. © 2010 Georg Thieme Verlag Stuttgart, New York.
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II / Bruno, C.; Lentini, G.; Catalano, A.; Carocci, A.; Lovece, A.; Di Mola, A.; Cavalluzzi, M. M.; Tortorella, P.; Loiodice, F.; Iaccarino, G.; Campiglia, P.; Novellino, E.; Franchini, C.. - In: SYNTHESIS. - ISSN 0039-7881. - 2010:24(2010), pp. 4193-4198. [10.1055/s-0030-1258298]
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II
Lentini G.;Carocci A.;Iaccarino G.;Novellino E.;
2010
Abstract
Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents- and allow ready preparation of the final compound in moderate- overall yields. Most of the synthetic steps proposed were microwave assisted. © 2010 Georg Thieme Verlag Stuttgart, New York.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
