(Figure Presented) We present a method for calculating accurate random coil chemical shift values of proteins. These values are obtained by analyzing the relationship between the amino acid sequences in flexible loop regions of native states and the corresponding experimentally measured chemical shifts. We estimate the errors in the random coil chemical shift scales to be 0.31 ppm for 13Cα, 0.37 ppm for 13Cβ, 0.31 ppm for 13CO, 0.68 ppm for 15N, 0.09 ppm for 1H, and 0.04 ppm for 1Hα. © 2009 American Chemical Society.
Accurate random coil chemical shifts from an analysis of loop regions in native states of proteins / De Simone, A.; Cavalli, A.; Hsu, S. -T. D.; Vranken, W.; Vendruscolo, M.. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 131:45(2009), pp. 16332-16333. [10.1021/ja904937a]
Accurate random coil chemical shifts from an analysis of loop regions in native states of proteins
De Simone A.;Cavalli A.;
2009
Abstract
(Figure Presented) We present a method for calculating accurate random coil chemical shift values of proteins. These values are obtained by analyzing the relationship between the amino acid sequences in flexible loop regions of native states and the corresponding experimentally measured chemical shifts. We estimate the errors in the random coil chemical shift scales to be 0.31 ppm for 13Cα, 0.37 ppm for 13Cβ, 0.31 ppm for 13CO, 0.68 ppm for 15N, 0.09 ppm for 1H, and 0.04 ppm for 1Hα. © 2009 American Chemical Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
