The monomeric resins tegdma and hema regulate the transcriptional control of matrix metalloproteinases mmp-2 and mmp-9 in human pulp fibroblasts and mesenchymal stem cells

Residual monomers, as triethylene-glycol-dimethacrylate (TEGDMA), 2-hydroxylethyl-methacrylate (HEMA), can be released from dental based-resin materials, as result of incomplete polymerization and induce cytotoxicity, genotoxicity and delay the cell cycle. It has been shown that dental monomers altered the Matrix Metalloproteinases (MMPs) activity. The MMPs are a family of proteolytic enzymes involved in extracellular matrix degradation. Our group, will study the role of these resins in the control of the molecular and physiological processes in human pulp fibroblasts and mesenchymal stem cells, such as transcription of MMP2 and MMP9 genes, apoptosis and cytotoxicity.