: In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC). As a matter of fact, liquid biopsy may supplant the problem of inadequate tissue for molecular testing. The term "liquid biopsy" refers to a number of different biological fluids, but is most clearly associated with plasma-related platforms. It must be taken into account that pre-analytical processing and the selection of the appropriate technology according to the clinical context may condition the results obtained. In addition, novel clinical applications beyond the evaluation of the molecular status of predictive biomarkers are currently under investigation.
Liquid Biopsy from research to clinical practice: focus on Non-Small Cell Lung Cancer / Malapelle, Umberto; Pisapia, Pasquale; Addeo, Alfredo; Arrieta, Oscar; Bellosillo, Beatriz; Cardona, Andres F; Cristofanilli, Massimo; de Miguel-Perez, Diego; Denninghoff, Valeria; Durán, Ignacio; Jantus-Lewintre, Eloísa; Nuzzo, Pier Vitale; O'Byrne, Ken; Pauwels, Patrick; Pickering, Edward M; Raez, Luis E; Russo, Alessandro; Serrano, Maria José; Gandara, David R; Troncone, Giancarlo; Rolfo, Christian. - In: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. - ISSN 1473-7159. - (2021). [10.1080/14737159.2021.1985468]
Liquid Biopsy from research to clinical practice: focus on Non-Small Cell Lung Cancer
Malapelle, Umberto;Pisapia, Pasquale;Troncone, Giancarlo;
2021
Abstract
: In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC). As a matter of fact, liquid biopsy may supplant the problem of inadequate tissue for molecular testing. The term "liquid biopsy" refers to a number of different biological fluids, but is most clearly associated with plasma-related platforms. It must be taken into account that pre-analytical processing and the selection of the appropriate technology according to the clinical context may condition the results obtained. In addition, novel clinical applications beyond the evaluation of the molecular status of predictive biomarkers are currently under investigation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.