Postbiotics - when simplification fails to clarify

Aguilar-Toalá, José Eleazar; Arioli, Stefania; Behare, Pradip; Belzer, Clara; Berni Canani, Roberto; Chatel, Jean-Marc; D'Auria, Enza; de Freitas, Mônica Queiroz; Elinav, Eran; Esmerino, Erick Almeida; García, Hugo S; da Cruz, Adriano Gomes; González-Córdova, Aarón F; Guglielmetti, Simone; de Toledo Guimarães, Jonas; Hernández-Mendoza, Adrián; Langella, Philippe; Liceaga, Andrea M; Magnani, Marciane; Martin, Rebeca; Mohamad Lal, Mohammad Tamrin; Mora, Diego; Moradi, Mehran; Morelli, Lorenzo; Mosca, Fabio; Nazzaro, Filomena; Pimentel, Tatiana Colombo; Ran, Chao; Ranadheera, Chaminda Senaka; Rescigno, Maria; Salas, Azucena; Sant'Ana, Anderson S; Sivieri, Katia; Sokol, Harry; Taverniti, Valentina; Vallejo-Cordoba, Belinda; Zelenka, Jaroslav; Zhou, Zhigang

doi:10.1038/s41575-021-00521-6

We appreciate the intent by Salminen et al. to clarify and reorganize the nomenclature regarding the use of inactivated bacteria and their products as health-promoting factors (Salminen, S. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat. Rev. Gastroenterol. Hepatol. 18, 649–667 (2021))1. Nonetheless, we found several major caveats in the consensus statement (Box 1) that might generate ambiguity.

Postbiotics - when simplification fails to clarify / Aguilar-Toalá, José Eleazar; Arioli, Stefania; Behare, Pradip; Belzer, Clara; Berni Canani, Roberto; Chatel, Jean-Marc; D'Auria, Enza; de Freitas, Mônica Queiroz; Elinav, Eran; Esmerino, Erick Almeida; García, Hugo S; da Cruz, Adriano Gomes; González-Córdova, Aarón F; Guglielmetti, Simone; de Toledo Guimarães, Jonas; Hernández-Mendoza, Adrián; Langella, Philippe; Liceaga, Andrea M; Magnani, Marciane; Martin, Rebeca; Mohamad Lal, Mohammad Tamrin; Mora, Diego; Moradi, Mehran; Morelli, Lorenzo; Mosca, Fabio; Nazzaro, Filomena; Pimentel, Tatiana Colombo; Ran, Chao; Ranadheera, Chaminda Senaka; Rescigno, Maria; Salas, Azucena; Sant'Ana, Anderson S; Sivieri, Katia; Sokol, Harry; Taverniti, Valentina; Vallejo-Cordoba, Belinda; Zelenka, Jaroslav; Zhou, Zhigang. - In: NATURE REVIEWS. GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1759-5045. - 18:(2021), pp. 825-826. [10.1038/s41575-021-00521-6]