Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays.

Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops / Ambrosone, Luigi; Guerra, Germano; Cinelli, Mariapia; Filippelli, Mariaelena; Mosca, Monica; Vizzarri, Francesco; Giorgio, Dario; Costagliola, Ciro. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - 2014:(2014), p. 471642. [10.1155/2014/471642]

Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops

GUERRA, Germano;COSTAGLIOLA, Ciro
2014

Abstract

Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays.
2014
Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops / Ambrosone, Luigi; Guerra, Germano; Cinelli, Mariapia; Filippelli, Mariaelena; Mosca, Monica; Vizzarri, Francesco; Giorgio, Dario; Costagliola, Ciro. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - 2014:(2014), p. 471642. [10.1155/2014/471642]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/871118
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