Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (alpha-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.

Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E / Fetoni, A; Ferraresi, A; Greca, Cl; Rizzo, D; Sergi, B; Tringali, G; Piacentini, R; Troiani, D. - In: NEUROREPORT. - ISSN 0959-4965. - 19:(2008), pp. 277-281.

Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E

FETONI A;
2008

Abstract

Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (alpha-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.
2008
Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E / Fetoni, A; Ferraresi, A; Greca, Cl; Rizzo, D; Sergi, B; Tringali, G; Piacentini, R; Troiani, D. - In: NEUROREPORT. - ISSN 0959-4965. - 19:(2008), pp. 277-281.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/871782
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