Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.
The retinoprotective role of phenytoin / Bartollino, Silvia; Chiosi, Flavia; di Staso, Silvio; Uva, Maurizio; Pascotto, Arduino; M Keppel Hesselink, Jan; Costagliola, Ciro; Rinaldi, Michele. - In: DRUG DESIGN, DEVELOPMENT AND THERAPY. - ISSN 1177-8881. - Volume 12:(2018), pp. 3485-3489. [10.2147/DDDT.S169621]
The retinoprotective role of phenytoin
Ciro Costagliola;Michele Rinaldi
2018
Abstract
Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.| File | Dimensione | Formato | |
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