Centella asiatica is a popular medicinal plant and several phytotherapic products in the market include its extracts as active constituents. A LC-MS guided phytochemical investigation on the commercial C. asiatica leaves extract named Centevita® allowed characterization and quantification of 24 secondary metabolites including 10 polyphenols and 14 ursane- or oleanane-type triterpenoids in the sapogenin or saponin form. This metabolomic analysis, besides confirming that the triterpenoid fraction roughly accounts for 45% of the extract weight, also resulted in the discovery of isoterminoloside, a new triglycoside saponin of the unprecedented 2α,3β,6β,23-tetrahydroxyolean-13(18)-en-28-oic acid (isoterminolic acid). The structure of isoterminoloside was characterized by a detailed ESI-MS and NMR investigation.
Phytochemical profile of Centevita®, a Centella asiatica leaves extract, and isolation of a new oleanane-type saponin / Masi, F.; Chianese, G.; Peterlongo, F.; Riva, A.; Taglialatela-Scafati, O.. - In: FITOTERAPIA. - ISSN 1873-6971. - 158:(2022), p. 105163. [10.1016/j.fitote.2022.105163]
Phytochemical profile of Centevita®, a Centella asiatica leaves extract, and isolation of a new oleanane-type saponin
Masi F.Primo
Investigation
;Chianese G.Secondo
Investigation
;Taglialatela-Scafati O.
Ultimo
Project Administration
2022
Abstract
Centella asiatica is a popular medicinal plant and several phytotherapic products in the market include its extracts as active constituents. A LC-MS guided phytochemical investigation on the commercial C. asiatica leaves extract named Centevita® allowed characterization and quantification of 24 secondary metabolites including 10 polyphenols and 14 ursane- or oleanane-type triterpenoids in the sapogenin or saponin form. This metabolomic analysis, besides confirming that the triterpenoid fraction roughly accounts for 45% of the extract weight, also resulted in the discovery of isoterminoloside, a new triglycoside saponin of the unprecedented 2α,3β,6β,23-tetrahydroxyolean-13(18)-en-28-oic acid (isoterminolic acid). The structure of isoterminoloside was characterized by a detailed ESI-MS and NMR investigation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
