Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
Covid-19 infection in children, infants and pregnant subjects: An overview of recent insights and therapies / Malcangi, G.; Inchingolo, A. D.; Inchingolo, A. M.; Santacroce, L.; Marinelli, G.; Mancini, A.; Vimercati, L.; Maggiore, M. E.; D'Oria, M. T.; Hazballa, D.; Bordea, I. R.; Xhajanka, E.; Scarano, A.; Farronato, M.; Tartaglia, G. M.; Giovanniello, D.; Nucci, L.; Serpico, R.; Sammartino, G.; Capozzi, L.; Parisi, A.; Di Domenico, M.; Lorusso, F.; Contaldo, M.; Inchingolo, F.; Dipalma, G.. - In: MICROORGANISMS. - ISSN 2076-2607. - 9:9(2021), p. 1964. [10.3390/microorganisms9091964]
Covid-19 infection in children, infants and pregnant subjects: An overview of recent insights and therapies
Scarano A.;Serpico R.;Sammartino G.;Capozzi L.;
2021
Abstract
Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
