Following the COVID-19 epidemic outbreak in Ariano Irpino, Campania region (Italy), we tested lactating cows for the presence of SARS-CoV-2 on a cattle farm at which, prior to the investigation, 13 of the 20 farmworkers showed COVID-19-like symptoms, and one of them died. Twenty-four lactating cows were sampled to detect SARS-CoV-2. All nasal and rectal swabs and milk samples were negative for SARS-CoV-2 RNA. Of the 24 collected serum samples, 11 showed antibodies against SARS-CoV-2 nucleocapsid protein, 14 showed antibodies against SARS-CoV-2 spike protein, and 13 developed neutralising antibodies for SARS-COV-2; all samples were negative for Bovine Coronavirus (BCoV), another betacoronavirus. To our knowledge, this is the first report of natural serological evidence of SARS-CoV-2 infection in lactating cows. We hypothesise that this may be a case of reverse zoonosis. However, the role of cattle in SARS-CoV-2 infection and transmission seems to be negligible.
First Description of Serological Evidence for SARS-CoV-2 in Lactating Cows / Fiorito, Filomena; Iovane, Valentina; Pagnini, Ugo; Cerracchio, Claudia; Brandi, Sergio; Levante, Martina; Marati, Luisa; Ferrara, Gianmarco; Tammaro, Virginio; De Carlo, Esterina; Iovane, Giuseppe; Fusco, Giovanna. - In: ANIMALS. - ISSN 2076-2615. - 12:11(2022), pp. 1459-1467. [10.3390/ani12111459]
First Description of Serological Evidence for SARS-CoV-2 in Lactating Cows
Fiorito, FilomenaPrimo
Investigation
;Iovane, ValentinaSecondo
Methodology
;Pagnini, UgoConceptualization
;Cerracchio, ClaudiaMethodology
;Ferrara, GianmarcoMethodology
;De Carlo, Esterina
Membro del Collaboration Group
;Iovane, Giuseppe
Penultimo
Conceptualization
;
2022
Abstract
Following the COVID-19 epidemic outbreak in Ariano Irpino, Campania region (Italy), we tested lactating cows for the presence of SARS-CoV-2 on a cattle farm at which, prior to the investigation, 13 of the 20 farmworkers showed COVID-19-like symptoms, and one of them died. Twenty-four lactating cows were sampled to detect SARS-CoV-2. All nasal and rectal swabs and milk samples were negative for SARS-CoV-2 RNA. Of the 24 collected serum samples, 11 showed antibodies against SARS-CoV-2 nucleocapsid protein, 14 showed antibodies against SARS-CoV-2 spike protein, and 13 developed neutralising antibodies for SARS-COV-2; all samples were negative for Bovine Coronavirus (BCoV), another betacoronavirus. To our knowledge, this is the first report of natural serological evidence of SARS-CoV-2 infection in lactating cows. We hypothesise that this may be a case of reverse zoonosis. However, the role of cattle in SARS-CoV-2 infection and transmission seems to be negligible.File | Dimensione | Formato | |
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