Although the protooncogenes small GTPases Ras are redox-sensitive proteins, how they are regulated by redox signaling in the central nervous system (CNS) is still poorly understood. Alteration in redox-sensitive targets by redox signaling may have myriad effects on Ras stability, activity and localization. Redox-mediated changes in astrocytic RAS may contribute to the control of redox homeostasis in the CNS that is connected to the pathogenesis of many diseases.
Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study / Zuchegna, Candida; DE ROSA, Valeria; Boscia, Francesca; Porcellini, Antonio; Messina, Samantha. - In: REDOX REPORT. - ISSN 1351-0002. - 27:1(2022), pp. 150-157. [10.1080/13510002.2022.2094109]
Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study
Candida ZuchegnaPrimo
Investigation
;Valeria de RosaInvestigation
;Francesca BosciaSupervision
;Antonio PorcelliniCo-ultimo
Supervision
;Samantha Messina
Co-ultimo
Writing – Original Draft Preparation
2022
Abstract
Although the protooncogenes small GTPases Ras are redox-sensitive proteins, how they are regulated by redox signaling in the central nervous system (CNS) is still poorly understood. Alteration in redox-sensitive targets by redox signaling may have myriad effects on Ras stability, activity and localization. Redox-mediated changes in astrocytic RAS may contribute to the control of redox homeostasis in the CNS that is connected to the pathogenesis of many diseases.| File | Dimensione | Formato | |
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Redox Report 2022.pdf
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