Insights into Myocardial Perfusion PET Imaging: the Coronary Flow Capacity

Purpose of Review The present work summarizes the clinical relevance of coronary flow capacity (CFC) with an eye on future perspectives. Recent findings CFC concept has been recently introduced providing a comprehensive framework for coronary physiology evaluation. Summary It has been widely demonstrated that coronary artery disease (CAD) is a complex disease with a multifactorial etiology resulting from different pathogenic mechanisms. Cardiac positron emission tomography (PET) currently represents the gold standard for CAD assessment, providing absolute myocardial perfusion data including coronary flow reserve (CFR), calculated as the ratio of hyperemic to rest absolute myocardial blood flows. CFC can be obtained from dynamic PET images by plotting the primary stress perfusion data and CFR values for each pixel on a graph of predefined exact ranges. The routine evaluation of this parameter may add diagnostic and prognostic value to clinical and conventional imaging data.