SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage.
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis / Galle-Treger, Lauriane; Moreau, Martine; Ballaire, Raphaëlle; Poupel, Lucie; Huby, Thomas; Sasso, Emanuele; Troise, Fulvia; Poti, Francesco; Lesnik, Philippe; Le Goff, Wilfried; Gautier, Emmanuel L; Huby, Thierry. - In: CARDIOVASCULAR RESEARCH. - ISSN 1755-3245. - 116:3(2020), pp. 554-565. [10.1093/cvr/cvz138]
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis
Sasso, Emanuele;Troise, Fulvia;
2020
Abstract
SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage.| File | Dimensione | Formato | |
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