The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.
First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina / Maione, Francesco; Bonito, Maria Camela; Colucci, Mariantonella; Cozzolino, Virginia; Bisio, Angela; Romussi, Giovanni; Cicala, Carla; Pieretti, Stefano; Mascolo, Nicola. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - 4:4(2009), pp. 469-472.
First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina
Maione, Francesco;Cozzolino, Virginia;Mascolo, Nicola
2009
Abstract
The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
