A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also detected in many personal care products and therefore can be absorbed by the skin. A solid/liquid extraction followed by a gradient elution chromatographic separation method was performed and validated according to European guidelines. Our validated method afforded the detection of all seven parabens with limit of detection values ranging from 0.026 to 0.090 μg mL−1 and recoveries ranging from 61.80 to 105.73 μg mL−1 at high and low concentration values (50.0–5.0 μg mL−1), respectively. The proposed method can help assess paraben’s skin bioaccumulation since people are repeatedly exposed to consumer goods containing parabens in their daily routine, posing a chronic risk to human health.
Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers / Di Lorenzo, Ritamaria; Neri, Ilaria; Russo, Giacomo; Laneri, Sonia; Grumetto, Lucia. - In: COSMETICS. - ISSN 2079-9284. - 9:5(2022), pp. 102-111. [10.3390/cosmetics9050102]
Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers
Di Lorenzo, Ritamaria;Neri, Ilaria;Laneri, Sonia;Grumetto, Lucia
2022
Abstract
A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also detected in many personal care products and therefore can be absorbed by the skin. A solid/liquid extraction followed by a gradient elution chromatographic separation method was performed and validated according to European guidelines. Our validated method afforded the detection of all seven parabens with limit of detection values ranging from 0.026 to 0.090 μg mL−1 and recoveries ranging from 61.80 to 105.73 μg mL−1 at high and low concentration values (50.0–5.0 μg mL−1), respectively. The proposed method can help assess paraben’s skin bioaccumulation since people are repeatedly exposed to consumer goods containing parabens in their daily routine, posing a chronic risk to human health.File | Dimensione | Formato | |
---|---|---|---|
cosmetics-09-00102.pdf
solo utenti autorizzati
Tipologia:
Versione Editoriale (PDF)
Licenza:
Accesso privato/ristretto
Dimensione
514.03 kB
Formato
Adobe PDF
|
514.03 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.