Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.
Stimuli-responsive transdermal microneedle patches / Makvandi, Pooyan; Jamaledin, Rezvan; Chen, Guojun; Baghbantaraghdari, Zahra; Nazarzadeh Zare, Ehsan; DI NATALE, Concetta; Onesto, Valentina; Vecchione, Raffaele; Lee, Jesse; Tay, Franklin R.; Netti, Paolo; Mattoli, Virgilio; Jaklenec, Ana; Gu, Zhen; Langer, Robert. - In: MATERIALS TODAY. - ISSN 1369-7021. - 47:(2021), pp. 206-222.
Stimuli-responsive transdermal microneedle patches
Rezvan Jamaledin;Concetta Di Natale;Paolo Netti;
2021
Abstract
Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
