The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols.
SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite / Poeta, Marco; Cioffi, Valentina; Buccigrossi, Vittoria; Corcione, Francesco; Peltrini, Roberto; Amoresano, Angela; Magurano, Fabio; Viscardi, Maurizio; Fusco, Giovanna; Tarallo, Antonietta; Damiano, Carla; Lo Vecchio, Andrea; Bruzzese, Eugenia; Guarino, Alfredo. - In: HELIYON. - ISSN 2405-8440. - 8:8(2022), p. e10246. [10.1016/j.heliyon.2022.e10246]
SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite
Poeta, Marco;Cioffi, Valentina;Buccigrossi, Vittoria;Corcione, Francesco;Peltrini, Roberto;Amoresano, Angela;Viscardi, Maurizio;Fusco, Giovanna;Tarallo, Antonietta;Damiano, Carla;Lo Vecchio, Andrea;Bruzzese, Eugenia;Guarino, Alfredo
2022
Abstract
The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
