For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. As most 5-Aza mechanisms of action are unknown, we investigated its phenotypic/molecular effects.
5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway / Tonon, Federica; Cemazar, Maja; Kamensek, Urska; Zennaro, Cristina; Pozzato, Gabriele; Caserta, Sergio; Ascione, Flora; Grassi, Mario; Guido, Stefano; Ferrari, Cinzia; Cansolino, Laura; Trotta, Francesco; Kuzmanov, Biljana Grcar; Forte, Giancarlo; Martino, Fabiana; Perrone, Francesca; Bomben, Riccardo; Gattei, Valter; Elvassore, Nicola; Murano, Erminio; Truong, Nhung Hai; Olson, Michael; Farra, Rossella; Grassi, Gabriele; Dapas, Barbara. - In: CANCERS. - ISSN 2072-6694. - 14:7(2022), p. 1630. [10.3390/cancers14071630]
5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway
Caserta, SergioData Curation
;Ascione, FloraFormal Analysis
;Guido, StefanoData Curation
;Martino, Fabiana;
2022
Abstract
For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. As most 5-Aza mechanisms of action are unknown, we investigated its phenotypic/molecular effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
