The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF A and addressed the identification of its molecular target in human dendritic cells (hDCs).
Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement / Gallo, C., Manzo, E., Barra, G., Fioretto, L., Ziaco, M., Nuzzo, G., D'Ippolito, G., Ferrera, F., Contini, P., Castiglia, D., Angelini, C., De Palma, R., Fontana, A.. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-9071. - 79:7(2022), p. 369. [10.1007/s00018-022-04297-z]
Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement
Gallo, Carmela
;Manzo, Emiliano;Fioretto, Laura;Ziaco, Marcello;Castiglia, Daniela;Fontana, Angelo
2022
Abstract
The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF A and addressed the identification of its molecular target in human dendritic cells (hDCs).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
