The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF A and addressed the identification of its molecular target in human dendritic cells (hDCs).
Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement / Gallo, Carmela; Manzo, Emiliano; Barra, Giusi; Fioretto, Laura; Ziaco, Marcello; Nuzzo, Genoveffa; D'Ippolito, Giuliana; Ferrera, Francesca; Contini, Paola; Castiglia, Daniela; Angelini, Claudia; De Palma, Raffaele; Fontana, Angelo. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-9071. - 79:7(2022), p. 369. [10.1007/s00018-022-04297-z]
Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement
Gallo, Carmela
;Manzo, Emiliano;Fioretto, Laura;Ziaco, Marcello;Castiglia, Daniela;Fontana, Angelo
2022
Abstract
The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF A and addressed the identification of its molecular target in human dendritic cells (hDCs).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
