Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis. Moreover, oxLDL are known to induce TF expression on several cell types including endothelial cells. The lectin-type oxidized LDL receptor 1 (LOX-1) represent the oxLDL receptor. Colchicine is an anti-mitotic drug recently proven to have beneficial effects in cardiovascular disease via unknown mechanisms. Thus, we aim at investigating colchicine effects on TF expression in oxLDL stimulated human vascular endothelial cells (HUVEC). Some molecular mechanism(s) potentially involved were investigated.

Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells / Cimmino, Giovanni; Conte, Stefano; Morello, Andrea; Pellegrino, Grazia; Marra, Laura; Calì, Gaetano; Golino, Paolo; Cirillo, Plinio. - In: VASCULAR PHARMACOLOGY. - ISSN 1537-1891. - (2021), p. 106822. [10.1016/j.vph.2020.106822]

Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells

Morello, Andrea;Pellegrino, Grazia;Cirillo, Plinio
2021

Abstract

Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis. Moreover, oxLDL are known to induce TF expression on several cell types including endothelial cells. The lectin-type oxidized LDL receptor 1 (LOX-1) represent the oxLDL receptor. Colchicine is an anti-mitotic drug recently proven to have beneficial effects in cardiovascular disease via unknown mechanisms. Thus, we aim at investigating colchicine effects on TF expression in oxLDL stimulated human vascular endothelial cells (HUVEC). Some molecular mechanism(s) potentially involved were investigated.
2021
Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells / Cimmino, Giovanni; Conte, Stefano; Morello, Andrea; Pellegrino, Grazia; Marra, Laura; Calì, Gaetano; Golino, Paolo; Cirillo, Plinio. - In: VASCULAR PHARMACOLOGY. - ISSN 1537-1891. - (2021), p. 106822. [10.1016/j.vph.2020.106822]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/915663
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