Monaco et al. generate an RNA-seq dataset on 29 immune cell types and identify modules of cell type-specific, co-expressed, and housekeeping genes. The mRNA heterogeneity and abundance of the different cell types were examined. Absolute deconvolution of PBMCs was obtained by taking into account mRNA abundance when normalizing the signature matrix.

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types / Monaco, G.; Lee, B.; Xu, W.; Mustafah, S.; Hwang, Y. Y.; Carre, C.; Burdin, N.; Visan, L.; Ceccarelli, M.; Poidinger, M.; Zippelius, A.; Pedro de Magalhaes, J.; Larbi, A.. - In: CELL REPORTS. - ISSN 2211-1247. - 26:6(2019), pp. 1627-1640. [10.1016/j.celrep.2019.01.041]

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

Ceccarelli M.;
2019

Abstract

Monaco et al. generate an RNA-seq dataset on 29 immune cell types and identify modules of cell type-specific, co-expressed, and housekeeping genes. The mRNA heterogeneity and abundance of the different cell types were examined. Absolute deconvolution of PBMCs was obtained by taking into account mRNA abundance when normalizing the signature matrix.
2019
RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types / Monaco, G.; Lee, B.; Xu, W.; Mustafah, S.; Hwang, Y. Y.; Carre, C.; Burdin, N.; Visan, L.; Ceccarelli, M.; Poidinger, M.; Zippelius, A.; Pedro de Magalhaes, J.; Larbi, A.. - In: CELL REPORTS. - ISSN 2211-1247. - 26:6(2019), pp. 1627-1640. [10.1016/j.celrep.2019.01.041]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/916079
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