We propose a multicellular implementation of a biomolecular PD feedback controller to regulate gene expression in a microbial consortium. The implementation involves distributing the proportional and derivative control actions between two different cellular populations that can communicate with each other and regulate the output of a third target cellular population. We derive analytical conditions on biological parameters and control gains to adjust the system's static and dynamical properties. We then validate the strategy's performance and robustness through extensive in silico experiments.
Multicellular PD Control in Microbial Consortia / Martinelli, V.; Salzano, D.; Fiore, D.; Di Bernardo, M.. - In: IEEE CONTROL SYSTEMS LETTERS. - ISSN 2475-1456. - 7:(2023), pp. 2641-2646. [10.1109/LCSYS.2023.3287136]
Multicellular PD Control in Microbial Consortia
Martinelli V.;Salzano D.;Fiore D.;Di Bernardo M.
2023
Abstract
We propose a multicellular implementation of a biomolecular PD feedback controller to regulate gene expression in a microbial consortium. The implementation involves distributing the proportional and derivative control actions between two different cellular populations that can communicate with each other and regulate the output of a third target cellular population. We derive analytical conditions on biological parameters and control gains to adjust the system's static and dynamical properties. We then validate the strategy's performance and robustness through extensive in silico experiments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
