Catch a match: The best biomolecular partner for a given calixarene host can be found by fishing in a crude HeLa cellular extract. In particular, a simply designed pacetamidocalix[ 4]arene was able to specifically fish out protein disulfide isomerase (PDI). Independent studies confirmed its considerable affinity for PDI (KD=11 mm), the inhibition of PDI chaperone activity, and cytotoxic activity against two cancer cell lines
Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach / Tommasone, Stefano; Talotta, Carmen; Gaeta, Carmine; Margarucci, Luigi; Monti, Maria Chiara; Casapullo, Agostino; Macchi, Betarice; Prete, Salvatore; Ladeira De Araujo, Adriana; Neri, Placido. - In: ANGEWANDTE CHEMIE. - ISSN 1521-3773. - 54:(2015), pp. 15405-15409. [10.1002/anie.201508651]
Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach
MONTI, Maria Chiara;CASAPULLO, Agostino;
2015
Abstract
Catch a match: The best biomolecular partner for a given calixarene host can be found by fishing in a crude HeLa cellular extract. In particular, a simply designed pacetamidocalix[ 4]arene was able to specifically fish out protein disulfide isomerase (PDI). Independent studies confirmed its considerable affinity for PDI (KD=11 mm), the inhibition of PDI chaperone activity, and cytotoxic activity against two cancer cell lines| File | Dimensione | Formato | |
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