The chemical and biological properties of anti-inflammatory marine natural products whose mechanism of action involves inhibition of phospholipase A2 (PLA2), an enzyme of key importance in the biosynthesis of proinflammatory chemical signals and mediators, has been reviewed. Remarkably, most marine natural products display a selective inhibition profile against secretory PLA2 enzymes, with little or null ability to interfere with cytosolic PLA2. Variabilin, a marine furano-terpene, appears to be a notable exception, endowed with a distinctive dual inhibitor profile towards both secretory and cytosolic PLA2 proteins.
Chemistry and Biology of Anti-Inflammatory Marine Natural Products.Phospholipase A2 Inhibitors / Luigi Gomez, Paloma; Monti, Maria Chiara; Terracciano, Stefania; Casapullo, Agostino; Riccio, Raffaele. - In: CURRENT ORGANIC CHEMISTRY. - ISSN 1385-2728. - 9:(2005), pp. 1419-1427. [10.2174/1385272054880205]
Chemistry and Biology of Anti-Inflammatory Marine Natural Products.Phospholipase A2 Inhibitors
MONTI, Maria Chiara;CASAPULLO, Agostino;RICCIO, Raffaele
2005
Abstract
The chemical and biological properties of anti-inflammatory marine natural products whose mechanism of action involves inhibition of phospholipase A2 (PLA2), an enzyme of key importance in the biosynthesis of proinflammatory chemical signals and mediators, has been reviewed. Remarkably, most marine natural products display a selective inhibition profile against secretory PLA2 enzymes, with little or null ability to interfere with cytosolic PLA2. Variabilin, a marine furano-terpene, appears to be a notable exception, endowed with a distinctive dual inhibitor profile towards both secretory and cytosolic PLA2 proteins.| File | Dimensione | Formato | |
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