Silver Nanoparticles in Dentistry: Investigating Research Prospects for Silver-Based Biomaterials

Objective: The objective of this paper was to provide an overview of the current knowledge and highlight areas where further research is needed and to address the limitations and enhance the understanding of silver-based biomaterials in dental practice. Methods: A comprehensive literature review was conducted to evaluate the existing research on silver-based biomaterials in dentistry. Relevant research articles were collected from electronic databases, including PubMed, Web of Science and Scopus. The identified literature was critically analyzed to identify areas that require further investigation. Results: The review revealed several research gaps in the application and use of silver-based biomaterials in dentistry. First, there is a need for long-term clinical studies to evaluate the performance and durability of silver-based biomaterials in various dental applications, including restorative materials, implant coatings and orthodontics. Additionally, studies focusing on the biocompatibility and tissue response to silver-based biomaterials are required to ensure their safety and minimize potential adverse effects. A deeper understanding of the mechanisms of action of silver-based biomaterials, including the release of silver ions and their interaction with oral microorganisms, would provide valuable insights for clinical decision making. Conclusions: Despite the growing interest in silver-based biomaterials in dentistry, there are several issues that need to be addressed to fully explore their capabilities and limitations. Long-term clinical trials, investigations into biocompatibility and tissue response and an understanding of the mechanisms of action are necessary to expand the knowledge base and ensure their effectiveness, safety and improved patient outcomes.