Background: Although multiple sclerosis (MS) Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a widely applied tool, no unique definition of sexual dysfunction (SD) based on its score exists. Objective: To explore the impact of different MSISQ-19 cut-offs on SD prevalence and associated risk factors, providing relevant information for its application in research and clinical settings. Methods: After defining SD according to two different MSISQ-19 cut-offs in 1155 people with MS (pwMS), we evaluated SD prevalence and association with sociodemographic and clinical features, mood status and disability via logistic regression. Results: Depending on the chosen cut-off, 45% to 54% of pwMS reported SD. SD defined as MSISQ-19 score >30 was predicted by age (OR=1.01, p=0.047), cognition (OR=0.96, p=0.004) and anxiety (OR=1.03, p=0.019). SD defined as a score >3 on any MSISQ-19 item was predicted by motor disability (OR=1.12, p=0.003) and cognition (OR= 0.96, p=0.002). Conclusion: Applying different MSISQ-19 cut-offs influences both the estimated prevalence and the identification of risk factors for SD, a finding that should be considered during study planning and data interpretation. Preserved cognition exerts a protective effect towards SD regardless from the specific study setting, representing a key point for the implementation of preventive and therapeutic strategies.

Sexual dysfunction in multiple sclerosis: The impact of different MSISQ-19 cut-offs on prevalence and associated risk factors / Petracca, M; Carotenuto, A; Scandurra, C; Moccia, M; Rosa, L; Arena, S; Ianniello, A; Nozzolillo, A; Turrini, M; Streito, L M; Abbadessa, G; Cellerino, M; Bucello, S; Ferraro, E; Mattioli, M; Chiodi, A; Inglese, M; Bonavita, S; Clerico, M; Cordioli, C; Moiola, L; Patti, F; Lavorgna, L; Filippi, M; Borriello, G; D'Amico, E; Pozzilli, C; Brescia Morra, V; Lanzillo, R. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0356. - 78:(2023). [10.1016/j.msard.2023.104907]

Sexual dysfunction in multiple sclerosis: The impact of different MSISQ-19 cut-offs on prevalence and associated risk factors

Petracca, M;Carotenuto, A;Scandurra, C;Moccia, M;Rosa, L;Nozzolillo, A;Abbadessa, G;Chiodi, A;Bonavita, S;Borriello, G;Brescia Morra, V;Lanzillo, R
2023

Abstract

Background: Although multiple sclerosis (MS) Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a widely applied tool, no unique definition of sexual dysfunction (SD) based on its score exists. Objective: To explore the impact of different MSISQ-19 cut-offs on SD prevalence and associated risk factors, providing relevant information for its application in research and clinical settings. Methods: After defining SD according to two different MSISQ-19 cut-offs in 1155 people with MS (pwMS), we evaluated SD prevalence and association with sociodemographic and clinical features, mood status and disability via logistic regression. Results: Depending on the chosen cut-off, 45% to 54% of pwMS reported SD. SD defined as MSISQ-19 score >30 was predicted by age (OR=1.01, p=0.047), cognition (OR=0.96, p=0.004) and anxiety (OR=1.03, p=0.019). SD defined as a score >3 on any MSISQ-19 item was predicted by motor disability (OR=1.12, p=0.003) and cognition (OR= 0.96, p=0.002). Conclusion: Applying different MSISQ-19 cut-offs influences both the estimated prevalence and the identification of risk factors for SD, a finding that should be considered during study planning and data interpretation. Preserved cognition exerts a protective effect towards SD regardless from the specific study setting, representing a key point for the implementation of preventive and therapeutic strategies.
2023
Sexual dysfunction in multiple sclerosis: The impact of different MSISQ-19 cut-offs on prevalence and associated risk factors / Petracca, M; Carotenuto, A; Scandurra, C; Moccia, M; Rosa, L; Arena, S; Ianniello, A; Nozzolillo, A; Turrini, M; Streito, L M; Abbadessa, G; Cellerino, M; Bucello, S; Ferraro, E; Mattioli, M; Chiodi, A; Inglese, M; Bonavita, S; Clerico, M; Cordioli, C; Moiola, L; Patti, F; Lavorgna, L; Filippi, M; Borriello, G; D'Amico, E; Pozzilli, C; Brescia Morra, V; Lanzillo, R. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0356. - 78:(2023). [10.1016/j.msard.2023.104907]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/962149
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