One of the unresolved problems of solid-phase organic synthesis (SPOS) is the availability of general and rapid methods to monitor the transformation of functional groups present in molecules supported on insoluble supports. Color tests, far from providing the ultimate solution, may help in detection (and sometimes in quantification) of different functional groups. In this short review, we have collected most of the methods available and applied in SPOS with an Experimental Section that describes the procedure we have successfully applied to bead analyses in our laboratories.
Colorimetric tools for solid-phase organic synthesis / Gaggini, F.; Porcheddu, A.; Reginato, G.; Rodriquez, M.; Taddei, M.. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 6:5(2004), pp. 805-810. [10.1021/cc049963a]
Colorimetric tools for solid-phase organic synthesis
Rodriquez M.;
2004
Abstract
One of the unresolved problems of solid-phase organic synthesis (SPOS) is the availability of general and rapid methods to monitor the transformation of functional groups present in molecules supported on insoluble supports. Color tests, far from providing the ultimate solution, may help in detection (and sometimes in quantification) of different functional groups. In this short review, we have collected most of the methods available and applied in SPOS with an Experimental Section that describes the procedure we have successfully applied to bead analyses in our laboratories.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
