2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na 2CO3, selective reduction of the γ-ester into alcohol with DIBAL and further transformation into aldehyde using Swern oxidation. The overall three-step procedure from Glu gave aldehyde in 49% yield. © Georg Thieme Verlag Stuttgart.
A simple procedure for the transformation of L-glutamic acid into the corresponding γ-aldehyde / Rodriquez, M.; Taddei, M.. - In: SYNTHESIS. - ISSN 0039-7881. - 2005:3(2005), pp. 493-495. [10.1055/s-2004-834865]
A simple procedure for the transformation of L-glutamic acid into the corresponding γ-aldehyde
Rodriquez M.Primo
;
2005
Abstract
2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na 2CO3, selective reduction of the γ-ester into alcohol with DIBAL and further transformation into aldehyde using Swern oxidation. The overall three-step procedure from Glu gave aldehyde in 49% yield. © Georg Thieme Verlag Stuttgart.File in questo prodotto:
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