Chromatin remodeling is a fundamental phenomenon in the life of eukaryotic cells, bearing implications to numerous physiological and pathological phenomena. This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with such biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors. Other aspects covered in this article comprise structure activity relationships (SAR) and modes of action at molecular level, including the description of crystal structures of enzyme-inhibitor complexes. © 2006 Bentham Science Publishers Ltd.
Chemistry and biology of chromatin remodeling agents: State of art and future perspectives of HDAC inhibitors / Rodriquez, Manuela; Aquino, M.; Bruno, I.; De Martino, G.; Taddei, M.; Gomez-Paloma, L.. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - 13:10(2006), pp. 1119-1139. [10.2174/092986706776360905]
Chemistry and biology of chromatin remodeling agents: State of art and future perspectives of HDAC inhibitors
Rodriquez ManuelaPrimo
;
2006
Abstract
Chromatin remodeling is a fundamental phenomenon in the life of eukaryotic cells, bearing implications to numerous physiological and pathological phenomena. This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with such biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors. Other aspects covered in this article comprise structure activity relationships (SAR) and modes of action at molecular level, including the description of crystal structures of enzyme-inhibitor complexes. © 2006 Bentham Science Publishers Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
