Purpose: To assess the effect of race/ethnicity in cancer-specific mortality (CSM) adjusted for other-cause mortality (OCM) in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy (EBRT) to the prostate. Methods: We relied on the Surveillance, Epidemiology, and End Results (SEER) database to identify Caucasian, African-American, Hispanic/Latino and Asian mPCa patients treated by EBRT between 2004 and 2016. Cumulative incidence plots displayed CSM after adjustment for OCM according to race/ethnicity. Propensity score matching accounted for patient age, prostate-specific antigen, clinical T and N stages, Gleason Grade Groups and M1 substages. OCM adjusted multivariable analyses tested for differences in CSM in African-Americans, Hispanic/Latinos and Asians relative to Cauacasians. Results: After 3:1 propensity score matching and OCM adjustment, Asians exhibited lower CSM at 60 and 120 months (48.2 and 60.0%, respectively) compared to Caucasians (66.7 and 79.4%, respectively, p < 0.001). In OCM adjusted multivariable analyses, Asian race/ethnicity was associated with lower CSM (HR 0.66, CI 0.52–0.83, p < 0.001). Conversely, African-American and Hispanic/Latino race/ethnicity did not affect CSM. OCM rates were comparable between examined races/ethnicities. Conclusion: In the setting of mPCa treated with EBRT, Asians exhibit lower CSM than Caucasians, African-Americans and Hispanic/Latinos. This observation may warrant consideration in prognostic stratification schemes for newly diagnosed mPCa patients.

Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities / Wurnschimmel, C.; Wenzel, M.; Colla' Ruvolo, Claudia.; Nocera, L.; Tian, Z.; Saad, F.; Briganti, A.; Shariat, S. F.; Mandel, P.; Chun, F. K. H.; Tilki, D.; Graefen, M.; Karakiewicz, P. I.. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - 39:10(2021), pp. 3781-3787. [10.1007/s00345-021-03720-7]

Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities

Colla' Ruvolo Claudia.;Briganti A.;
2021

Abstract

Purpose: To assess the effect of race/ethnicity in cancer-specific mortality (CSM) adjusted for other-cause mortality (OCM) in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy (EBRT) to the prostate. Methods: We relied on the Surveillance, Epidemiology, and End Results (SEER) database to identify Caucasian, African-American, Hispanic/Latino and Asian mPCa patients treated by EBRT between 2004 and 2016. Cumulative incidence plots displayed CSM after adjustment for OCM according to race/ethnicity. Propensity score matching accounted for patient age, prostate-specific antigen, clinical T and N stages, Gleason Grade Groups and M1 substages. OCM adjusted multivariable analyses tested for differences in CSM in African-Americans, Hispanic/Latinos and Asians relative to Cauacasians. Results: After 3:1 propensity score matching and OCM adjustment, Asians exhibited lower CSM at 60 and 120 months (48.2 and 60.0%, respectively) compared to Caucasians (66.7 and 79.4%, respectively, p < 0.001). In OCM adjusted multivariable analyses, Asian race/ethnicity was associated with lower CSM (HR 0.66, CI 0.52–0.83, p < 0.001). Conversely, African-American and Hispanic/Latino race/ethnicity did not affect CSM. OCM rates were comparable between examined races/ethnicities. Conclusion: In the setting of mPCa treated with EBRT, Asians exhibit lower CSM than Caucasians, African-Americans and Hispanic/Latinos. This observation may warrant consideration in prognostic stratification schemes for newly diagnosed mPCa patients.
2021
Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities / Wurnschimmel, C.; Wenzel, M.; Colla' Ruvolo, Claudia.; Nocera, L.; Tian, Z.; Saad, F.; Briganti, A.; Shariat, S. F.; Mandel, P.; Chun, F. K. H.; Tilki, D.; Graefen, M.; Karakiewicz, P. I.. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - 39:10(2021), pp. 3781-3787. [10.1007/s00345-021-03720-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/977899
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