WHO global research priorities for antimicrobial resistance in human health

Bertagnolio, Silvia; Dobreva, Zlatina; Centner, Chad M; Olaru, Ioana Diana; Donà, Daniele; Burzo, Stefano; Huttner, Benedikt D; Chaillon, Antoine; Gebreselassie, Nebiat; Teodora, Wi; Hasso-Agopsowicz, Mateusz; Allegranzi, Benedetta; Sati, Hatim; Ivanovska, Verica; Kothari, Kavita U; Balkhy, Hanan H; Cassini, Alessandro; Hamers, Raph L; Weezenbeek,; Kitty Van Weezenbeek,; WHO Research Agenda for AMR in Human Health Collaborators: David Aanensen 12,; Alexandre Alanio 13,; Ana Alastruey-Izquierdo 14,; Tinsae Alemayehu 15,; Majdi Al-Hasan 16,; Karel Allegaert 17,; Amal Saif Al-Maani 18,; Jameela Al-Salman 19,; Abeer Nizar Alshukairi 20,; Afreenish Amir 21,; Tanya Applegate 22,; George, F Araj 23; Marlen Arce Villalobos 24,; Christine Årdal 25,; Diane Ashiru-Oredope 26,; Elizabeth, A Ashley 27; François-Xavier Babin 28,; Laura, H Bachmann 29; Till Bachmann 30,; Kate Susan Baker 31,; Manica Balasegaram 32,; Colleen Bamford 33,; Fernando Baquero 34,; Laura Isabel Barcelona 35,; Quique Bassat 36,; Matteo Bassetti 37,; Sulagna Basu 38,; Justin Beardsley 39,; Grey Benoit Vásquez 40,; James, A Berkley 41; Anuj, K Bhatnagar 42; Julia Bielicki 43,; Julie Bines 44,; Felix Bongomin 45,; Robert, A Bonomo 46; John, S Bradley 47; Catriona Bradshaw 48,; Ana Brett 49,; Adrian Brink 50,; Colin Brown 26,; Jeremy Brown 51,; Kirsty Buising 52,; Carolee Carson 53,; Anna Cristina Carvalho 54,; Elio Castagnola 55,; Marco Cavaleri 56,; Michele Cecchini 57,; Chishala Chabala 58,; Richard, E Chaisson 59; Arunaloke Chakrabarti 60,; Clare Chandler 61,; Sujith John Chandy 62,; Esmita Charani 63,; Lisa Chen 64,; Francesca Chiara 65,; Anuradha Chowdhary 66,; Arlene Chua 67,; Pem Chuki 68,; Doo Ryeon Chun 69,; Gavin Churchyard 70,; Daniela Cirillo 71,; Lauren Clack 72,; Susan, E Coffin 73; Jennifer Cohn 32,; Michelle Cole 74,; John Conly 75,; Ben Cooper 12,; Alejandra Corso 76,; Sara, E Cosgrove 77; Helen Cox 78,; Charles, L Daley 79; Saffiatou Darboe 80,; Tom Darton 81,; Gerry Davies 82,; Viviana de Egea 83,; Amela Dedeić-Ljubović 84,; Miranda Deeves 85,; Claudia Denkinger 86,; Jo-Anne, R Dillon 87; Angela Dramowski 88,; Brian Eley 89,; Susanna Maria Roberta Esposito 90,; Sabiha, Y Essack 91; Helmia Farida 92,; Joveria Farooqi 93,; Nicholas Feasey 94,; Cecilia Ferreyra 95,; Helen Fifer 26,; Heather Finlayson 88,; Mike Frick 96,; Ana Cristina Gales 97,; Luisa Galli 98,; Sumanth Gandra 99,; Jeffrey, S Gerber 100; Christian Giske 101,; Bruce Gordon 85,; Nelesh Govender 102,; Nathalie Guessennd 103,; Ibrehima Guindo 104,; Elmira Gurbanova 105,; Amanda Gwee 106,; Ferry Hagen 107,; Stephan Harbarth 108,; John Haze 109,; Jutta Heim 110,; Rene Hendriksen 111,; Robert Simon Heyderman 112,; Kathryn Elizabeth Holt 61,; Martin Hönigl 113,; Edward, W Hook 114; William Hope 82,; Heidi Hopkins 61,; Gwenda Hughes 61,; Ghada Ismail 115,; Mohammad Iqbal Issack 116,; Jan Jacobs 117,; Dušan Jasovský 118,; Fyeza Jehan 119,; Antonieta Jimenez Pearson 120,; Makoto Jones 121,; Mohan, P Joshi 122; Arti Kapil 123,; Samuel Kariuki 124,; Abhilasha Karkey 125,; Gregory, L Kearns 126; Karen Helena Keddy 127,; Nina Khanna 128,; Akiko Kitamura 129,; Kaija-Leena Kolho 130,; Dimitrios, P Kontoyiannis 131; Anita Kotwani 132,; Roman, S Kozlov 133; Katharina Kranzer 61,; Ranmini Kularatne 134,; Monica, M Lahra 135; Bradley, J Langford 136; Rafael Laniado-Laborin 137,; Joakim Larsson 138,; Cornelia Lass-Flörl 139,; Kirsty Le Doare 140,; Hyukmin Lee 141,; Fernanda Lessa 29,; Anna, S Levin 142; Direk Limmathurotsakul 143,; Nilton Lincopan 144,; LO VECCHIO, Andrea; Rakesh Lodha 146,; Mark Loeb 147,; Yves Longtin 148,; David Chien Lye 149,; Asif Mujtaba Mahmud 150,; Célia Manaia 151,; Lenore Manderson 152,; Ivana Mareković 153,; Kalisvar Marimuthu 154,; Irene Martin 155,; Tapfumanei Mashe 156,; Zeng Mei 157,; Jacques, F Meis 158; Flávio Augusto Lyra Tavares De Melo 159,; Marc Mendelson 50,; Angelica Espinosa Miranda 160,; David Moore 161,; Chantal Morel 162,; Nyambura Moremi 163,; Maria Luisa Moro 164,; Francis Moussy 85,; Stephen Mshana 165,; Arno Mueller 85,; Francis, J Ndow 166; Mark Nicol 167,; Andrew Nunn 168,; Stephen Obaro 169,; Christina, W Obiero 170; Iruka, N Okeke 171; Uduak Okomo 172,; Tochi, J Okwor 173; Rita Oladele 174,; Sylvia Omulo 175,; Pascale Ondoa 176,; Juana Medarda Ortellado de Canese 177,; Luis Ostrosky-Zeichner 178,; Maria Clara Padoveze 179,; Madhukar Pai 180,; Benjamin Park 29,; Julian Parkhill 181,; Christopher, M Parry 182; Rosanna Peeling 61,; Luísa Maria Sobreira Vieira Peixe 183,; Olga Perovic 184,; Melinda, M Pettigrew 185; Nicola Principi 186,; Céline Pulcini 187,; Nelly Puspandari 188,; Timothy Rawson 63,; Denasha Lavanya Reddy 152,; Kessendri Reddy 152,; Paulo Redner 189,; Juan Luis Rodríguez Tudela 190,; Jesús Rodríguez-Baño 191,; Susan Rogers Van Katwyk 192,; Emmanuel Roilides 193,; Christine Rollier 194,; Leslie Rollock 195,; Jean-Baptiste Ronat 196,; Etienne Ruppe 197,; Manish Sadarangani 198,; David Salisbury 199,; Mounerou Salou 200,; Luc Hervé Samison 201,; Maurizio Sanguinetti 202,; Massimo Sartelli 203,; Natalie Schellack 204,; Jeroen Schouten 205,; Mitchell, J Schwaber 206; Jeremiah Seni 207,; Abiola Senok 208,; William, M Shafer 209; Sadia Shakoor 210,; Donald Sheppard 53,; Jong-Hee Shin 211,; Sonia Sia 212,; Dawn Sievert 29,; Ishwar Singh 213,; Rupak Singla 214,; Robert Leo Skov 215,; Olusegun, O Soge 216; Rosanne Sprute 217,; Arjun Srinivasan 218,; Subasree Srinivasan 29,; Arnfinn Sundsfjord 219,; Evelina Tacconelli 220,; Sabira Tahseen 221,; Viroj Tangcharoensathien 222,; Thomas Tängdén 223,; Karin Thursky 224,; Guy Thwaites 225,; Renata Tigulini de Souza Peral 226,; Deborah Tong 85,; Hafsah Deepa Tootla 227,; Constantinos Tsioutis 228,; Katy, M Turner 229; Paul Turner 229,; Shaheed Vally Omar 230,; Wendy Wj van de Sande 231,; Susan van den Hof 232,; Rogier van Doorn 233,; Balaji Veeraraghavan 234,; Paul Verweij 235,; Retno Wahyuningsih 236,; Hui Wang 237,; Adilia Warris 238,; Hillard Weinstock 239,; Evelyn Wesangula 240,; David Whiley 218,; Peter, J White 241; Phoebe Williams 242,; Yonghong Xiao 243,; Martin Yagui Moscoso 244,; Hsu Li Yang 245,; Sachiyo Yoshida 85,; Yunsong Yu 246,; Żabick, Dorota; Zignol, Matteo

doi:10.1016/S2666-5247(24)00134-4

: The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

WHO global research priorities for antimicrobial resistance in human health / Silvia, Bertagnolio; Zlatina, Dobreva; Chad M, Centner; Ioana Diana, Olaru; Daniele, Donà; Stefano, Burzo; Benedikt D, Huttner; Antoine, Chaillon; Nebiat, Gebreselassie; Teodora, Wi; Mateusz, Hasso-Agopsowicz; Benedetta, Allegranzi; Hatim, Sati; Verica, Ivanovska; Kavita U, Kothari; Hanan H, Balkhy; Alessandro, Cassini; Raph L, Hamers; Weezenbeek, ; Van Weezenbeek, Kitty; Research Agenda for AMR in Human Health Collaborators: David Aanensen 12, Who; Alanio 13, Alexandre; Alastruey-Izquierdo 14, Ana; Alemayehu 15, Tinsae; Al-Hasan 16, Majdi; Allegaert 17, Karel; Saif Al-Maani 18, Amal; Al-Salman 19, Jameela; Nizar Alshukairi 20, Abeer; Amir 21, Afreenish; Applegate 22, Tanya; F Araj 23, George; Arce Villalobos 24, Marlen; Årdal 25, Christine; Ashiru-Oredope 26, Diane; A Ashley 27, Elizabeth; Babin 28, François-Xavier; H Bachmann 29, Laura; Bachmann 30, Till; Susan Baker 31, Kate; Balasegaram 32, Manica; Bamford 33, Colleen; Baquero 34, Fernando; Isabel Barcelona 35, Laura; Bassat 36, Quique; Bassetti 37, Matteo; Basu 38, Sulagna; Beardsley 39, Justin; Benoit Vásquez 40, Grey; A Berkley 41, James; K Bhatnagar 42, Anuj; Bielicki 43, Julia; Bines 44, Julie; Bongomin 45, Felix; A Bonomo 46, Robert; S Bradley 47, John; Bradshaw 48, Catriona; Brett 49, Ana; Brink 50, Adrian; Brown 26, Colin; Brown 51, Jeremy; Buising 52, Kirsty; Carson 53, Carolee; Cristina Carvalho 54, Anna; Castagnola 55, Elio; Cavaleri 56, Marco; Cecchini 57, Michele; Chabala 58, Chishala; E Chaisson 59, Richard; Chakrabarti 60, Arunaloke; Chandler 61, Clare; John Chandy 62, Sujith; Charani 63, Esmita; Chen 64, Lisa; Chiara 65, Francesca; Chowdhary 66, Anuradha; Chua 67, Arlene; Chuki 68, Pem; Ryeon Chun 69, Doo; Churchyard 70, Gavin; Cirillo 71, Daniela; Clack 72, Lauren; E Coffin 73, Susan; Cohn 32, Jennifer; Cole 74, Michelle; Conly 75, John; Cooper 12, Ben; Corso 76, Alejandra; E Cosgrove 77, Sara; Cox 78, Helen; L Daley 79, Charles; Darboe 80, Saffiatou; Darton 81, Tom; Davies 82, Gerry; de Egea 83, Viviana; Dedeić-Ljubović 84, Amela; Deeves 85, Miranda; Denkinger 86, Claudia; R Dillon 87, Jo-Anne; Dramowski 88, Angela; Eley 89, Brian; Maria Roberta Esposito 90, Susanna; Y Essack 91, Sabiha; Farida 92, Helmia; Farooqi 93, Joveria; Feasey 94, Nicholas; Ferreyra 95, Cecilia; Fifer 26, Helen; Finlayson 88, Heather; Frick 96, Mike; Cristina Gales 97, Ana; Galli 98, Luisa; Gandra 99, Sumanth; S Gerber 100, Jeffrey; Giske 101, Christian; Gordon 85, Bruce; Govender 102, Nelesh; Guessennd 103, Nathalie; Guindo 104, Ibrehima; Gurbanova 105, Elmira; Gwee 106, Amanda; Hagen 107, Ferry; Harbarth 108, Stephan; Haze 109, John; Heim 110, Jutta; Hendriksen 111, Rene; Simon Heyderman 112, Robert; Elizabeth Holt 61, Kathryn; Hönigl 113, Martin; W Hook 114, Edward; Hope 82, William; Hopkins 61, Heidi; Hughes 61, Gwenda; Ismail 115, Ghada; Iqbal Issack 116, Mohammad; Jacobs 117, Jan; Jasovský 118, Dušan; Jehan 119, Fyeza; Jimenez Pearson 120, Antonieta; Jones 121, Makoto; P Joshi 122, Mohan; Kapil 123, Arti; Kariuki 124, Samuel; Karkey 125, Abhilasha; L Kearns 126, Gregory; Helena Keddy 127, Karen; Khanna 128, Nina; Kitamura 129, Akiko; Kolho 130, Kaija-Leena; P Kontoyiannis 131, Dimitrios; Kotwani 132, Anita; S Kozlov 133, Roman; Kranzer 61, Katharina; Kularatne 134, Ranmini; M Lahra 135, Monica; J Langford 136, Bradley; Laniado-Laborin 137, Rafael; Larsson 138, Joakim; Lass-Flörl 139, Cornelia; Le Doare 140, Kirsty; Lee 141, Hyukmin; Lessa 29, Fernanda; S Levin 142, Anna; Limmathurotsakul 143, Direk; Lincopan 144, Nilton; LO VECCHIO, Andrea; Lodha 146, Rakesh; Loeb 147, Mark; Longtin 148, Yves; Chien Lye 149, David; Mujtaba Mahmud 150, Asif; Manaia 151, Célia; Manderson 152, Lenore; Mareković 153, Ivana; Marimuthu 154, Kalisvar; Martin 155, Irene; Mashe 156, Tapfumanei; Mei 157, Zeng; F Meis 158, Jacques; Augusto Lyra Tavares De Melo 159, Flávio; Mendelson 50, Marc; Espinosa Miranda 160, Angelica; Moore 161, David; Morel 162, Chantal; Moremi 163, Nyambura; Luisa Moro 164, Maria; Moussy 85, Francis; Mshana 165, Stephen; Mueller 85, Arno; J Ndow 166, Francis; Nicol 167, Mark; Nunn 168, Andrew; Obaro 169, Stephen; W Obiero 170, Christina; N Okeke 171, Iruka; Okomo 172, Uduak; J Okwor 173, Tochi; Oladele 174, Rita; Omulo 175, Sylvia; Ondoa 176, Pascale; Medarda Ortellado de Canese 177, Juana; Ostrosky-Zeichner 178, Luis; Clara Padoveze 179, Maria; Pai 180, Madhukar; Park 29, Benjamin; Parkhill 181, Julian; M Parry 182, Christopher; Peeling 61, Rosanna; Maria Sobreira Vieira Peixe 183, Luísa; Perovic 184, Olga; M Pettigrew 185, Melinda; Principi 186, Nicola; Pulcini 187, Céline; Puspandari 188, Nelly; Rawson 63, Timothy; Lavanya Reddy 152, Denasha; Reddy 152, Kessendri; Redner 189, Paulo; Luis Rodríguez Tudela 190, Juan; Rodríguez-Baño 191, Jesús; Rogers Van Katwyk 192, Susan; Roilides 193, Emmanuel; Rollier 194, Christine; Rollock 195, Leslie; Ronat 196, Jean-Baptiste; Ruppe 197, Etienne; Sadarangani 198, Manish; Salisbury 199, David; Salou 200, Mounerou; Hervé Samison 201, Luc; Sanguinetti 202, Maurizio; Sartelli 203, Massimo; Schellack 204, Natalie; Schouten 205, Jeroen; J Schwaber 206, Mitchell; Seni 207, Jeremiah; Senok 208, Abiola; M Shafer 209, William; Shakoor 210, Sadia; Sheppard 53, Donald; Shin 211, Jong-Hee; Sia 212, Sonia; Sievert 29, Dawn; Singh 213, Ishwar; Singla 214, Rupak; Leo Skov 215, Robert; O Soge 216, Olusegun; Sprute 217, Rosanne; Srinivasan 218, Arjun; Srinivasan 29, Subasree; Sundsfjord 219, Arnfinn; Tacconelli 220, Evelina; Tahseen 221, Sabira; Tangcharoensathien 222, Viroj; Tängdén 223, Thomas; Thursky 224, Karin; Thwaites 225, Guy; Tigulini de Souza Peral 226, Renata; Tong 85, Deborah; Deepa Tootla 227, Hafsah; Tsioutis 228, Constantinos; M Turner 229, Katy; Turner 229, Paul; Vally Omar 230, Shaheed; Wj van de Sande 231, Wendy; van den Hof 232, Susan; van Doorn 233, Rogier; Veeraraghavan 234, Balaji; Verweij 235, Paul; Wahyuningsih 236, Retno; Wang 237, Hui; Warris 238, Adilia; Weinstock 239, Hillard; Wesangula 240, Evelyn; Whiley 218, David; J White 241, Peter; Williams 242, Phoebe; Xiao 243, Yonghong; Yagui Moscoso 244, Martin; Li Yang 245, Hsu; Yoshida 85, Sachiyo; Yu 246, Yunsong; Żabick, Dorota; Zignol, Matteo. - In: THE LANCET MICROBE. - ISSN 2666-5247. - (2024), pp. 1-14. [10.1016/S2666-5247(24)00134-4]