: Clostridium perfingens bloodstream infections (BSIs) can be associated with high mortality rates. We performed a subanalysis of all C. perfringens BSIs enrolled during a multicentric retrospective observational study (ITANAEROBY). Data were collected from January 2016 to December 2020. C. perfringens BSIs were 134 (134/1960, 6.8 %). The highest resistance rate was observed for clindamycin (26/120, 21.6 %), penicillin (11/71, 15.4 %) and metronidazole (14/131, 10.7 %). In conclusion, C. perfringens reduced susceptibility phenotype to first-line therapy.
A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY) / Geremia, Nicholas; Sanson, Gianfranco; Principe, Luigi; Antonello, Roberta Maria; Zerbato, Verena; Luzzati, Roberto; Maraolo, Alberto Enrico; Giacobbe, Daniele Roberto; Sepulcri, Chiara; Ambretti, Simone; Aschbacher, Richard; Bartolini, Laura; Bernardo, Mariano; Bielli, Alessandra; Busetti, Marina; Carcione, Davide; Camarlinghi, Giulio; Carretto, Edoardo; Cassetti, Tiziana; Chilleri, Chiara; De Rosa, Francesco Giuseppe; Dodaro, Saveria; Gargiulo, Raffaele; Greco, Francesca; Knezevich, Anna; Intra, Jari; Lupia, Tommaso; Concialdi, Erika; Bianco, Gabriele; Luzzaro, Francesco; Mauri, Carola; Morroni, Gianluca; Mosca, Adriana; Pagani, Elisabetta; Parisio, Eva Maria; Ucciferri, Claudio; Vismara, Chiara; Di Bella, Stefano. - In: ANAEROBE. - ISSN 1075-9964. - 90:(2024). [10.1016/j.anaerobe.2024.102901]
A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)
Maraolo, Alberto EnricoMembro del Collaboration Group
;Bernardo, Mariano;
2024
Abstract
: Clostridium perfingens bloodstream infections (BSIs) can be associated with high mortality rates. We performed a subanalysis of all C. perfringens BSIs enrolled during a multicentric retrospective observational study (ITANAEROBY). Data were collected from January 2016 to December 2020. C. perfringens BSIs were 134 (134/1960, 6.8 %). The highest resistance rate was observed for clindamycin (26/120, 21.6 %), penicillin (11/71, 15.4 %) and metronidazole (14/131, 10.7 %). In conclusion, C. perfringens reduced susceptibility phenotype to first-line therapy.| File | Dimensione | Formato | |
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