: The emergence of COronaVIrus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presented a global health challenge since its identification in December 2019. With clinical manifestations ranging from mild respiratory symptoms to severe multi-organ dysfunction, COVID-19 continues to affect populations worldwide. The complex interactions between SARS-CoV-2 variants and the human immune system are crucial for developing effective therapies, vaccines, and preventive measures. Understanding these immune responses highlights the intricate nature of COVID-19 pathogenesis. This retrospective study analyzed, by flow cytometry approach, a cohort of patients infected with SARS-CoV-2 during the initial pandemic waves from 2020 to 2021. It focused on untreated individuals at the time of hospital admission and examined the presence of TR3-56 cells in their immune profiles during the anti-viral immune response. Our findings provide additional insights into the complex immunological dynamics of SARS-CoV-2 infection and highlight the potential role of TR3-56 cells as crucial components of the immune response. We suggest that TR3-56 cells could serve as valuable biomarkers for identifying more severe cases of COVID-19, aiding in the assessment and management of the disease.

Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection / Carriero, Flavia; Rubino, Valentina; Gelzo, Monica; Scalia, Giulia; Raia, Maddalena; Ciccozzi, Massimo; Gentile, Ivan; Pinchera, Biagio; Castaldo, Giuseppe; Ruggiero, Giuseppina; Terrazzano, Giuseppe. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:19(2024), pp. 1-13. [10.3390/ijms251910465]

Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection

Rubino, Valentina;Gelzo, Monica;Scalia, Giulia;Raia, Maddalena;Gentile, Ivan;Pinchera, Biagio;Castaldo, Giuseppe;Ruggiero, Giuseppina;
2024

Abstract

: The emergence of COronaVIrus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presented a global health challenge since its identification in December 2019. With clinical manifestations ranging from mild respiratory symptoms to severe multi-organ dysfunction, COVID-19 continues to affect populations worldwide. The complex interactions between SARS-CoV-2 variants and the human immune system are crucial for developing effective therapies, vaccines, and preventive measures. Understanding these immune responses highlights the intricate nature of COVID-19 pathogenesis. This retrospective study analyzed, by flow cytometry approach, a cohort of patients infected with SARS-CoV-2 during the initial pandemic waves from 2020 to 2021. It focused on untreated individuals at the time of hospital admission and examined the presence of TR3-56 cells in their immune profiles during the anti-viral immune response. Our findings provide additional insights into the complex immunological dynamics of SARS-CoV-2 infection and highlight the potential role of TR3-56 cells as crucial components of the immune response. We suggest that TR3-56 cells could serve as valuable biomarkers for identifying more severe cases of COVID-19, aiding in the assessment and management of the disease.
2024
Immune Profile in COVID-19: Unveiling TR3-56 Cells in SARS-CoV-2 Infection / Carriero, Flavia; Rubino, Valentina; Gelzo, Monica; Scalia, Giulia; Raia, Maddalena; Ciccozzi, Massimo; Gentile, Ivan; Pinchera, Biagio; Castaldo, Giuseppe; Ruggiero, Giuseppina; Terrazzano, Giuseppe. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:19(2024), pp. 1-13. [10.3390/ijms251910465]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/983627
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