: Long-term weight loss maintenance represents a big challenge for the management of obesity. This narrative review aims to provide an overview of the main endocrine mechanisms involved in weight regain in subjects with obesity and to review the current evidence on the best lifestyle approaches, including diet and physical activity. Weight regain after weight loss occurs in about 50% of subjects with obesity in the absence of lifestyle changes. The primary endocrine mechanism responsible for weight regain involves the brain-gut axis, which encourages food intake and thus weight regain through the secretion and action of several gastrointestinal hormones, such as ghrelin, leptin and cholecystokinin. Several evidence reported changes of secretion of these hormones during weight loss and weight loss maintenance programs. Endurance training is the most effective physical activity to lose and keep weight loss; the association of endurance with resistance training is recommended for remodelling body shape.

The challenge of weight loss maintenance in obesity: a review of the evidence on the best strategies available / Barrea, Luigi; Salzano, Ciro; Pugliese, Gabriella; Laudisio, Daniela; Frias-Toral, Evelyn; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna. - In: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION. - ISSN 0963-7486. - 73:8(2022), pp. 1030-1046. [10.1080/09637486.2022.2130186]

The challenge of weight loss maintenance in obesity: a review of the evidence on the best strategies available

Barrea, Luigi;Salzano, Ciro;Pugliese, Gabriella;Laudisio, Daniela;Savastano, Silvia;Colao, Annamaria;Muscogiuri, Giovanna
2022

Abstract

: Long-term weight loss maintenance represents a big challenge for the management of obesity. This narrative review aims to provide an overview of the main endocrine mechanisms involved in weight regain in subjects with obesity and to review the current evidence on the best lifestyle approaches, including diet and physical activity. Weight regain after weight loss occurs in about 50% of subjects with obesity in the absence of lifestyle changes. The primary endocrine mechanism responsible for weight regain involves the brain-gut axis, which encourages food intake and thus weight regain through the secretion and action of several gastrointestinal hormones, such as ghrelin, leptin and cholecystokinin. Several evidence reported changes of secretion of these hormones during weight loss and weight loss maintenance programs. Endurance training is the most effective physical activity to lose and keep weight loss; the association of endurance with resistance training is recommended for remodelling body shape.
2022
The challenge of weight loss maintenance in obesity: a review of the evidence on the best strategies available / Barrea, Luigi; Salzano, Ciro; Pugliese, Gabriella; Laudisio, Daniela; Frias-Toral, Evelyn; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna. - In: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION. - ISSN 0963-7486. - 73:8(2022), pp. 1030-1046. [10.1080/09637486.2022.2130186]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/985161
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