: Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.

Whole-genome sequencing reveals host factors underlying critical COVID-19 / Kousathanas, Athanasios; Pairo-Castineira, Erola; Rawlik, Konrad; Stuckey, Alex; Odhams, Christopher A.; Walker, Susan; Russell, Clark D.; Malinauskas, Tomas; Wu, Yang; Millar, Jonathan; Shen, Xia; Elliott, Katherine S.; Griffiths, Fiona; Oosthuyzen, Wilna; Morrice, Kirstie; Keating, Sean; Wang, Bo; Rhodes, Daniel; Klaric, Lucija; Zechner, Marie; Parkinson, Nick; Siddiq, Afshan; Goddard, Peter; Donovan, Sally; Maslove, David; Nichol, Alistair; Semple, Malcolm G.; Zainy, Tala; Maleady-Crowe, Fiona; Todd, Linda; Salehi, Shahla; Knight, Julian; Elgar, Greg; Chan, Georgia; Arumugam, Prabhu; Patch, Christine; Rendon, Augusto; Bentley, David; Kingsley, Clare; Kosmicki, Jack A.; Horowitz, Julie E.; Baras, Aris; Abecasis, Goncalo R.; Ferreira, Manuel A. R.; Justice, Anne; Mirshahi, Tooraj; Oetjens, Matthew; Rader, Daniel J.; Ritchie, Marylyn D.; Verma, Anurag; Fowler, Tom A.; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; Mcauley, Danny; Montgomery, Hugh; Openshaw, Peter J. M.; Elliott, Paul; Walsh, Timothy; Tenesa, Albert; Null, Null; Null, Null; Baillie, J. Kenneth; Begg, Colin; Clohisey Hendry, Sara; Hinds, Charles; Horby, Peter; Knight, Julian; Ling, Lowell; Maslove, David; Mcauley, Danny; Millar, Johnny; Montgomery, Hugh; Nichol, Alistair; Openshaw, Peter J. M.; Pereira, Alexandre C.; Ponting, Chris P.; Rowan, Kathy; Semple, Malcolm G.; Shankar-Hari, Manu; Summers, Charlotte; Walsh, Timothy; Null, Null; Aravindan, Latha; Armstrong, Ruth; Biggs, Heather; Boz, Ceilia; Brown, Adam; Clark, Richard; Coutts, Audrey; Coyle, Judy; Cullum, Louise; Das, Sukamal; Day, Nicky; Donnelly, Lorna; Duncan, Esther; Fawkes, Angie; Finernan, Paul; Fourman, Max Head; Furlong, Anita; Furniss, James; Gallagher, Bernadette; Gilchrist, Tammy; Golightly, Ailsa; Griffiths, Fiona; Hafezi, Katarzyna; Hamilton, Debbie; Hendry, Ross; Law, Andy; Law, Dawn; Law, Rachel; Law, Sarah; Lidstone-Scott, Rebecca; Macgillivray, Louise; Maclean, Alan; Mal, Hanning; Mccafferty, Sarah; Mcmaster, Ellie; Meikle, Jen; Moore, Shona C.; Morrice, Kirstie; Murphy, Lee; Murphy, Sheena; Hellen, Mybaya; Oosthuyzen, Wilna; Zheng, Chenqing; Chen, Jiantao; Parkinson, Nick; Paterson, Trevor; Schon, Katherine; Stenhouse, Andrew; Das, Mihaela; Swets, Maaike; Szoor-McElhinney, Helen; Taneski, Filip; Turtle, Lance; Wackett, Tony; Ward, Mairi; Weaver, Jane; Wrobel, Nicola; Zechner, Marie; Null, Null; Arbane, Gill; Bociek, Aneta; Campos, Sara; Grau, Neus; Jones, Tim Owen; Lim, Rosario; Marotti, Martina; Ostermann, Marlies; Shankar-Hari, Manu; Whitton, Christopher; Null, Null; Alldis, Zoe; Astin-Chamberlain, Raine; Bibi, Fatima; Biddle, Jack; Blow, Sarah; Bolton, Matthew; Borra, Catherine; Bowles, Ruth; Burton, Maudrian; Choudhury, Yasmin; Collier, David; Cox, Amber; Easthope, Amy; Ebano, Patrizia; Fotiadis, Stavros; Gurasashvili, Jana; Halls, Rosslyn; Hartridge, Pippa; Kallon, Delordson; Kassam, Jamila; Lancoma-Malcolm, Ivone; Matharu, Maninderpal; May, Peter; Mitchelmore, Oliver; Newman, Tabitha; Patel, Mital; Pheby, Jane; Pinzuti, Irene; Prime, Zoe; Prysyazhna, Oleksandra; Shiel, Julian; Taylor, Melanie; Tierney, Carey; Wood, Suzanne; Zak, Anne; Zongo, Olivier; Null, Null; Bonner, Stephen; Hugill, Keith; Jones, Jessica; Liggett, Steven; Headlam, Evie; Null, Null; Bandla, Nageswar; Gellamucho, Minnie; Davies, Michelle; Thompson, Christopher; Null, Null; Abdelrazik, Marwa; Bakthavatsalam, Dhanalakshmi; Elhassan, Munzir; Ganesan, Arunkumar; Haldeos, Anne; Moreno-Cuesta, Jeronimo; Purohit, Dharam; Vincent, Rachel; Xavier, Kugan; Kumar, Rohit; Frater, Alasdair; Saleem, Malik; Carter, David; Jenkins, Samuel; Lamond, Zoe; Wall, Alanna; Null, Null; Fernandez-Roman, Jaime; Hamilton, David O.; Johnson, Emily; Johnston, Brian; Martinez, Maria Lopez; Mulla, Suleman; Shaw, David; Waite, Alicia A. C.; Waugh, Victoria; Welters, Ingeborg D.; Williams, Karen; Null, Null; Cavazza, Anna; Cockrell, Maeve; Corcoran, Eleanor; Depante, Maria; Finney, Clare; Jerome, Ellen; Mcphail, Mark; Nayak, Monalisa; Noble, Harriet; O'Reilly, Kevin; Pappa, Evita; Saha, Rohit; Saha, Sian; Smith, John; Knighton, Abigail; Null, Null; Antcliffe, David; Banach, Dorota; Brett, Stephen; Coghlan, Phoebe; Fernandez, Ziortza; Gordon, Anthony; Rojo, Roceld; Arias, Sonia Sousa; Templeton, Maie; Null, Null; Meredith, Megan; Morris, Lucy; Ryan, Lucy; Clark, Amy; Sampson, Julia; Peters, Cecilia; Dent, Martin; Langley, Margaret; Ashraf, Saima; Wei, Shuying; Andrew, Angela; Null, Null; Bashyal, Archana; Davidson, Neil; Hutton, Paula; Mckechnie, Stuart; Wilson, Jean; Null, Null; Baptista, David; Crowe, Rebecca; Fernandes, Rita; Herdman-Grant, Rosaleen; Joseph, Anna; O'Connor, Denise; Allen, Meryem; Loveridge, Adam; Mckenley, India; Morino, Eriko; Naranjo, Andres; Simms, Richard; Sollesta, Kathryn; Swain, Andrew; Venkatesh, Harish; Khera, Jacyntha; Fox, Jonathan; Null, Null; Andrew, Gillian; Baillie, J. Kenneth; Barclay, Lucy; Callaghan, Marie; Campbell, Rachael; Clark, Sarah; Hope, Dave; Marshall, Lucy; Mcculloch, Corrienne; Briton, Kate; Singleton, Jo; Birch, Sophie; Null, Null; Brimfield, Lutece; Daly, Zoe; Pogson, David; Rose, Steve; Nown, Angela; Null, Null; Battle, Ceri; Brinkworth, Elaine; Harford, Rachel; Murphy, Carl; Newey, Luke; Rees, Tabitha; Williams, Marie; Arnold, Sophie; Null, Null; Polgarova, Petra; Stroud, Katerina; Summers, Charlotte; Meaney, Eoghan; Jones, Megan; Ng, Anthony; Agrawal, Shruti; Pathan, Nazima; White, Deborah; Daubney, Esther; Elston, Kay; Null, Null; Grauslyte, Lina; Hussain, Musarat; Phull, Mandeep; Pogreban, Tatiana; Rosaroso, Lace; Salciute, Erika; Franke, George; Wong, Joanna; George, Aparna; Null, Null; de Gordoa, Laura Ortiz-Ruiz; Peasgood, Emily; Phillips, Claire; Null, Null; Bates, Michelle; Dasgin, Jo; Gill, Jaspret; Nilsson, Annette; Scriven, James; Collins, Amy; Khaliq, Waqas; Gude, Estefania Treus; Null, Null; Delgado, Carlos Castro; Dawson, Deborah; Ding, Lijun; Durrant, Georgia; Ezeobu, Obiageri; Farnell-Ward, Sarah; Harrison, Abiola; Kanu, Rebecca; Leaver, Susannah; Maccacari, Elena; Manna, Soumendu; Saluzzio, Romina Pepermans; Queiroz, Joana; Samakomva, Tinashe; Sicat, Christine; Texeira, Joana; Da Gloria, Edna Fernandes; Lisboa, Ana; Rawlins, John; Mathew, Jisha; Kinch, Ashley; Hurt, William James; Shah, Nirav; Clark, Victoria; Thanasi, Maria; Yun, Nikki; Patel, Kamal; Null, Null; Bennett, Sara; Goodwin, Emma; Jackson, Matthew; Kent, Alissa; Tibke, Clare; Woodyatt, Wiesia; Zaki, Ahmed; Null, Null; Abraheem, Azmerelda; Bamford, Peter; Cawley, Kathryn; Dunmore, Charlie; Faulkner, Maria; Girach, Rumanah; Jeffrey, Helen; Jones, Rhianna; London, Emily; Nagra, Imrun; Nasir, Farah; Sainsbury, Hannah; Smedley, Clare; Null, Null; Patel, Tahera; Smith, Matthew; Chukkambotla, Srikanth; Kazi, Aayesha; Hartley, Janice; Dykes, Joseph; Hijazi, Muhammad; Keith, Sarah; Khan, Meherunnisa; Ryan-Smith, Janet; Springle, Philippa; Thomas, Jacqueline; Truman, Nick; Saad, Samuel; Coleman, Dabheoc; Fine, Christopher; Matt, Roseanna; Gay, Bethan; Dalziel, Jack; Ali, Syamlan; Goodchild, Drew; Harling, Rhiannan; Bhatterjee, Ravi; Goddard, Wendy; Davison, Chloe; Duberly, Stephen; Hargreaves, Jeanette; Bolton, Rachel; Null, Null; Davey, Miriam; Golden, David; Seaman, Rebecca; Null, Null; Cherian, Shiney; Cutler, Sean; Heron, Anne Emma; Roynon-Reed, Anna; Szakmany, Tamas; Williams, Gemma; Richards, Owen; Cheema, Yusuf; Null, Null; Brooke, Hollie; Buckley, Sarah; Suarez, Jose Cebrian; Charlesworth, Ruth; Hansson, Karen; Norris, John; Poole, Alice; Rose, Alastair; Sandhu, Rajdeep; Sloan, Brendan; Smithson, Elizabeth; Thirumaran, Muthu; Wagstaff, Veronica; Metcalfe, Alexandra; Null, Null; Brunton, Mark; Caterson, Jess; Coles, Holly; Frise, Matthew; Rai, Sabi Gurung; Jacques, Nicola; Keating, Liza; Tilney, Emma; Bartley, Shauna; Bhuie, Parminder; Null, Null; Gibson, Sian; Lyle, Amanda; Mcneela, Fiona; Radhakrishnan, Jayachandran; Hughes, Alistair; Null, Null; Yates, Bryan; Reynolds, Jessica; Campbell, Helen; Thompsom, Maria; Dodds, Steve; Duffy, Stacey; Null, Null; Greer, Sandra; Shuker, Karen; Tridente, Ascanio; Null, Null; Khade, Reena; Sundar, Ashok; Tsinaslanidis, George; Null, Null; Birkinshaw, Isobel; Carter, Joseph; Howard, Kate; Ingham, Joanne; Joy, Rosie; Pearson, Harriet; Roche, Samantha; Scott, Zoe; Null, Null; Bancroft, Hollie; Bellamy, Mary; Carmody, Margaret; Daglish, Jacqueline; Moore, Faye; Rhodes, Joanne; Sangombe, Mirriam; Kadiri, Salma; Scriven, James; Null, Null; Croft, Maria; White, Ian; Frost, Victoria; Aquino, Maia; Null, Null; Jha, Rajeev; Krishnamurthy, Vinodh; Lim, Lai; Lim, Li; Null, Null; Combes, Edward; Joefield, Teishel; Monnery, Sonja; Beech, Valerie; Trotman, Sallyanne; Null, Null; Almaden-Boyle, Christine; Austin, Pauline; Cabrelli, Louise; Cole, Stephen; Casey, Matt; Chapman, Susan; Whyte, Clare; Null, Null; Baird, Yolanda; Butler, Aaron; Chadbourn, Indra; Folkes, Linda; Fox, Heather; Gardner, Amy; Gomez, Raquel; Hobden, Gillian; Hodgson, Luke; King, Kirsten; Margarson, Michael; Martindale, Tim; Meadows, Emma; Raynard, Dana; Thirlwall, Yvette; Helm, David; Margalef, Jordi; Null, Null; Criste, Kristine; Cusack, Rebecca; Golder, Kim; Golding, Hannah; Jones, Oliver; Leggett, Samantha; Male, Michelle; Marani, Martyna; Prager, Kirsty; Williams, Toran; Roberts, Belinda; Salmon, Karen; Null, Null; Anderson, Peter; Archer, Katie; Austin, Karen; Davis, Caroline; Durie, Alison; Kelsall, Olivia; Thrush, Jessica; Vigurs, Charlie; Wild, Laura; Wood, Hannah-Louise; Tranter, Helen; Harrison, Alison; Cowley, Nicholas; Mcalindon, Michael; Burtenshaw, Andrew; Digby, Stephen; Low, Emma; Morgan, Aled; Cother, Naiara; Rankin, Tobias; Clayton, Sarah; Mccurdy, Alex; Null, Null; Ahmed, Cecilia; Baines, Balvinder; Clamp, Sarah; Colley, Julie; Haq, Risna; Hayes, Anne; Hulme, Jonathan; Hussain, Samia; Joseph, Sibet; Kumar, Rita; Maqsood, Zahira; Purewal, Manjit; Null, Null; Benham, Leonie; Bradshaw, Zena; Brown, Joanna; Caswell, Melanie; Cupitt, Jason; Melling, Sarah; Preston, Stephen; Slawson, Nicola; Stoddard, Emma; Warden, Scott; Null, Null; Deacon, Bethan; Lynch, Ceri; Pothecary, Carla; Roche, Lisa; Howe, Gwenllian Sera; Singh, Jayaprakash; Turner, Keri; Ellis, Hannah; Stroud, Natalie; Null, Null; Hunt, Jodie; Dearden, Joy; Dobson, Emma; Drummond, Andy; Mulcahy, Michelle; Munt, Sheila; O'Connor, Grainne; Philbin, Jennifer; Rishton, Chloe; Tully, Redmond; Winnard, Sarah; Null, Null; Cathcart, Susanne; Duffy, Katharine; Puxty, Alex; Puxty, Kathryn; Turner, Lynne; Ireland, Jane; Semple, Gary; Null, Null; Long, Kate; Whiteley, Simon; Wilby, Elizabeth; Ogg, Bethan; Null, Null; Cowton, Amanda; Kay, Andrea; Kent, Melanie; Potts, Kathryn; Wilkinson, Ami; Campbell, Suzanne; Brown, Ellen; Null, Null; Melville, Julie; Naisbitt, Jay; Joseph, Rosane; Lazo, Maria; Walton, Olivia; Neal, Alan; Null, Null; Alexander, Peter; Allen, Schvearn; Bradley-Potts, Joanne; Brantwood, Craig; Egan, Jasmine; Felton, Timothy; Padden, Grace; Ward, Luke; Moss, Stuart; Glasgow, Susannah; Null, Null; Abel, Lynn; Brett, Michael; Digby, Brian; Gemmell, Lisa; Hornsby, James; Macgoey, Patrick; O'Neil, Pauline; Price, Richard; Rodden, Natalie; Rooney, Kevin; Sundaram, Radha; Thomson, Nicola; Null, Null; Hopkins, Bridget; Scriven, James; Thrasyvoulou, Laura; Willis, Heather; Null, Null; Clark, Martyn; Coulding, Martina; Jude, Edward; Mccormick, Jacqueline; Mercer, Oliver; Potla, Darsh; Rehman, Hafiz; Savill, Heather; Turner, Victoria; Null, Null; Downes, Charlotte; Holding, Kathleen; Riches, Katie; Hilton, Mary; Hayman, Mel; Subramanian, Deepak; Daniel, Priya; Null, Null; Adanini, Oluronke; Bhatia, Nikhil; Msiska, Maines; Collins, Rebecca; Null, Null; Clement, Ian; Patel, Bijal; Gulati, A.; Hays, Carole; Webster, K.; Hudson, Anne; Webster, Andrea; Stephenson, Elaine; Mccormack, Louise; Slater, Victoria; Nixon, Rachel; Hanson, Helen; Fearby, Maggie; Kelly, Sinead; Bridgett, Victoria; Robinson, Philip; Null, Null; Camsooksai, Julie; Humphrey, Charlotte; Jenkins, Sarah; Reschreiter, Henrik; Wadams, Beverley; Death, Yasmin; Null, Null; Bastion, Victoria; Clarke, Daphene; David, Beena; Kent, Harriet; Lorusso, Rachel; Lubimbi, Gamu; Murdoch, Sophie; Penacerrada, Melchizedek; Thomas, Alastair; Valentine, Jennifer; Vochin, Ana; Wulandari, Retno; Djeugam, Brice; Null, Null; Bell, Gillian; English, Katy; Katary, Amro; Wilcox, Louise; Null, Null; Bruce, Michelle; Connolly, Karen; Duncan, Tracy; Michael, Helen T.; Lindergard, Gabriella; Hey, Samuel; Fox, Claire; Alfonso, Jordan; Durrans, Laura Jayne; Guerin, Jacinta; Blackledge, Bethan; Harris, Jade; Hruska, Martin; Eltayeb, Ayaa; Lamb, Thomas; Hodgkiss, Tracey; Cooper, Lisa; Rothwell, Joanne; Null, Null; Allan, Angela; Anderson, Felicity; Kaye, Callum; Liew, Jade; Medhora, Jasmine; Scott, Teresa; Trumper, Erin; Botello, Adriana; Null, Null; Lankester, Liana; Nikitas, Nikitas; Wells, Colin; Stowe, Bethan; Spencer, Kayleigh; Null, Null; Brandwood, Craig; Smith, Lara; Clark, Richard; Birchall, Katie; Kolakaluri, Laurel; Baines, Deborah; Sukumaran, Anila; Null, Null; Apetri, Elena; Basikolo, Cathrine; Blackledge, Bethan; Catlow, Laura; Charles, Bethan; Dark, Paul; Doonan, Reece; Harris, Jade; Harvey, Alice; Horner, Daniel; Knowles, Karen; Lee, Stephanie; Lomas, Diane; Lyons, Chloe; Marsden, Tracy; Mclaughlan, Danielle; Mcmorrow, Liam; Pendlebury, Jessica; Perez, Jane; Poulaka, Maria; Proudfoot, Nicola; Slaughter, Melanie; Slevin, Kathryn; Taylor, Melanie; Thomas, Vicky; Walker, Danielle; Michael, Angiy; Collis, Matthew; Null, Null; Cosier, Tracey; Millen, Gemma; Richardson, Neil; Schumacher, Natasha; Weston, Heather; Rand, James; Null, Null; Baxter, Nicola; Henderson, Steven; Kennedy-Hay, Sophie; Mcparland, Christopher; Rooney, Laura; Sim, Malcolm; Mccreath, Gordan; Null, Null; Akeroyd, Louise; Bano, Shereen; Bromley, Matt; Gurr, Lucy; Lawton, Tom; Morgan, James; Sellick, Kirsten; Warren, Deborah; Wilkinson, Brian; Mcgowan, Janet; Ledgard, Camilla; Stacey, Amelia; Pye, Kate; Bellwood, Ruth; Bentley, Michael; Null, Null; Bewley, Jeremy; Garland, Zoe; Grimmer, Lisa; Gumbrill, Bethany; Johnson, Rebekah; Sweet, Katie; Webster, Denise; Efford, Georgia; Null, Null; Convery, Karen; Fottrell-Gould, Deirdre; Hudig, Lisa; Keshet-Price, Jocelyn; Randell, Georgina; Stammers, Katie; Null, Null; Bokhari, Maria; Linnett, Vanessa; Lucas, Rachael; Mccormick, Wendy; Ritzema, Jenny; Sanderson, Amanda; Wild, Helen; Null, Null; Rostron, Anthony; Roy, Alistair; Woods, Lindsey; Cornell, Sarah; Wakinshaw, Fiona; Rogerson, Kimberley; Jarmain, Jordan; Null, Null; Parker, Robert; Reddy, Amie; Turner-Bone, Ian; Wilding, Laura; Harding, Peter; Null, Null; Abernathy, Caroline; Foster, Louise; Gratrix, Andrew; Martinson, Vicky; Parkinson, Priyai; Stones, Elizabeth; Carbral-Ortega, Llucia; Null, Null; Bercades, Georgia; Brealey, David; Hass, Ingrid; Maccallum, Niall; Martir, Gladys; Raith, Eamon; Reyes, Anna; Smyth, Deborah; Null, Null; Zitter, Letizia; Benyon, Sarah; Marriott, Suzie; Park, Linda; Keenan, Samantha; Gordon, Elizabeth; Quinn, Helen; Baines, Kizzy; Null, Null; Cagova, Lenka; Fofano, Adama; Garner, Lucie; Holcombe, Helen; Mepham, Sue; Mitchell, Alice Michael; Mwaura, Lucy; Praman, Krithivasan; Vuylsteke, Alain; Zamikula, Julie; Null, Null; Purewal, Bally; Rivers, Vanessa; Bell, Stephanie; Null, Null; Blakemore, Hayley; Borislavova, Borislava; Faulkner, Beverley; Gendall, Emma; Goff, Elizabeth; Hayes, Kati; Thomas, Matt; Worner, Ruth; Smith, Kerry; Stephens, Deanna; Null, Null; Mew, Louise; Mwaura, Esther; Stewart, Richard; Williams, Felicity; Wren, Lynn; Sutherland, Sara-Beth; Null, Null; Bevan, Emily; Martin, Jane; Trodd, Dawn; Watson, Geoff; Wrey Brown, Caroline; Null, Null; Akinkugbe, Olugbenga; Bamford, Alasdair; Beech, Emily; Belfield, Holly; Bell, Michael; Davies, Charlene; Jones, Gareth A. L.; Mchugh, Tara; Meghari, Hamza; O'Neill, Lauran; Peters, Mark J.; Ray, Samiran; Tomas, Ana Luisa; Null, Null; Burn, Iona; Hambrook, Geraldine; Manso, Katarina; Penn, Ruth; Shanmugasundaram, Pradeep; Tebbutt, Julie; Thornton, Danielle; Null, Null; Cole, Jade; Davies, Michelle; Davies, Rhys; Duffin, Donna; Hill, Helen; Player, Ben; Thomas, Emma; Williams, Angharad; Null, Null; Griffin, Denise; Muchenje, Nycola; Mupudzi, Mcdonald; Partridge, Richard; Conyngham, Jo-Anna; Thomas, Rachel; Wright, Mary; Corral, Maria Alvarez; Null, Null; Jacob, Reni; Jones, Cathy; Denmade, Craig; Null, Null; Beavis, Sarah; Dale, Katie; Gascoyne, Rachel; Hawes, Joanne; Pritchard, Kelly; Stevenson, Lesley; Whileman, Amanda; Null, Null; Doble, Patricia; Hutter, Joanne; Pawley, Corinne; Shovelton, Charmaine; Vaida, Marius; Null, Null; Butcher, Deborah; O'Sullivan, Susie; Butterworth-Cowin, Nicola; Null, Null; Ahmad, Norfaizan; Barker, Joann; Bauchmuller, Kris; Bird, Sarah; Cawthron, Kay; Harrington, Kate; Jackson, Yvonne; Kibutu, Faith; Lenagh, Becky; Masuko, Shamiso; Mills, Gary H.; Raithatha, Ajay; Wiles, Matthew; Willson, Jayne; Newell, Helen; Lye, Alison; Nwafor, Lorenza; Jarman, Claire; Rowland-Jones, Sarah; Foote, David; Cole, Joby; Thompson, Roger; Watson, James; Hesseldon, Lisa; Macharia, Irene; Chetam, Luke; Smith, Jacqui; Ford, Amber; Anderson, Samantha; Birchall, Kathryn; Housley, Kay; Walker, Sara; Milner, Leanne; Hanratty, Helena; Trower, Helen; Phillips, Patrick; Oxspring, Simon; Donne, Ben; Null, Null; Jardine, Catherine; Williams, Dewi; Hay, Alasdair; Null, Null; Flanagan, Rebecca; Hughes, Gareth; Latham, Scott; Mckenna, Emma; Anderson, Jennifer; Hull, Robert; Rhead, Kat; Null, Null; Cruz, Carina; Pattison, Natalie; Null, Null; Charnock, Rob; Mcfarland, Denise; Cosgrove, Denise; Null, Null; Ahmed, Ashar; Morris, Anna; Jakkula, Srinivas; Nune, Arvind; Null, Null; Ali, Asifa; Brady, Megan; Dale, Sam; Dance, Annalisa; Gledhill, Lisa; Greig, Jill; Hanson, Kathryn; Holdroyd, Kelly; Home, Marie; Kelly, Diane; Kitson, Ross; Matapure, Lear; Melia, Deborah; Mellor, Samantha; Nortcliffe, Tonicha; Pinnell, Jez; Robinson, Matthew; Shaw, Lisa; Shaw, Ryan; Thomis, Lesley; Wilson, Alison; Wood, Tracy; Bayo, Lee-Ann; Merwaha, Ekta; Ishaq, Tahira; Hanley, Sarah; Null, Null; Deacon, Bethan; Hibbert, Meg; Pothecary, Carla; Tetla, Dariusz; Woodford, Christopher; Durga, Latha; Kennard-Holden, Gareth; Null, Null; Branney, Debbie; Frankham, Jordan; Pitts, Sally; White, Nigel; Null, Null; Laha, Shondipon; Verlander, Mark; Williams, Alexandra; Null, Null; Altabaibeh, Abdelhakim; Alvaro, Ana; Gilbert, Kayleigh; Ma, Louise; Mostoles, Loreta; Parmar, Chetan; Simpson, Kathryn; Jetha, Champa; Booker, Lauren; Pratley, Anezka; Null, Null; Adams, Colene; Agasou, Anita; Arden, Tracie; Bowes, Amy; Boyle, Pauline; Beekes, Mandy; Button, Heather; Capps, Nigel; Carnahan, Mandy; Carter, Anne; Childs, Danielle; Donaldson, Denise; Hard, Kelly; Hurford, Fran; Hussain, Yasmin; Javaid, Ayesha; Jones, James; Jose, Sanal; Leigh, Michael; Martin, Terry; Millward, Helen; Motherwell, Nichola; Rikunenko, Rachel; Stickley, Jo; Summers, Julie; Ting, Louise; Tivenan, Helen; Tonks, Louise; Wilcox, Rebecca; Skinner, Denise; Gaylard, Jane; Mullan, Dee; Newman, Julie; Null, Null; Holland, Maureen; Keenan, Natalie; Lyons, Marc; Wassall, Helen; Marsh, Chris; Mahenthran, Mervin; Carter, Emma; Kong, Thomas; Null, Null; Blackman, Helen; Creagh-Brown, Ben; Donlon, Sinead; Michalak-Glinska, Natalia; Mtuwa, Sheila; Pristopan, Veronika; Salberg, Armorel; Smith, Eleanor; Stone, Sarah; Piercy, Charles; Verula, Jerik; Burda, Dorota; Montaser, Rugia; Harden, Lesley; Mayangao, Irving; Marriott, Cheryl; Bradley, Paul; Harris, Celia; Null, Null; Anderson, Susan; Andrews, Eleanor; Birch, Janine; Collins, Emma; Hammerton, Kate; O'Leary, Ryan; Null, Null; Clark, Michele; Purvis, Sarah; Null, Null; Barber, Russell; Hewitt, Claire; Hilldrith, Annette; Jackson-Lawrence, Karen; Shepardson, Sarah; Wills, Maryanne; Butler, Susan; Tavares, Silvia; Cunningham, Amy; Hindale, Julia; Arif, Sarwat; Null, Null; Bean, Sarah; Burt, Karen; Spivey, Michael; Null, Null; Demetriou, Carrie; Eckbad, Charlotte; Hierons, Sarah; Howie, Lucy; Mitchard, Sarah; Ramos, Lidia; Serrano-Ruiz, Alfredo; White, Katie; Kelly, Fiona; Null, Null; Cristiano, Daniele; Dormand, Natalie; Farzad, Zohreh; Gummadi, Mahitha; Liyanage, Kamal; Patel, Brijesh; Salmi, Sara; Sloane, Geraldine; Thwaites, Vicky; Varghese, Mathew; Zborowski, Anelise C.; Null, Null; Allan, John; Geary, Tim; Houston, Gordon; Meikle, Alistair; O'Brien, Peter; Null, Null; Forsey, Miranda; Kaliappan, Agilan; Nicholson, Anne; Riches, Joanne; Vertue, Mark; Null, Null; Allan, Elizabeth; Darlington, Kate; Davies, Ffyon; Easton, Jack; Kumar, Sumit; Lean, Richard; Menzies, Daniel; Pugh, Richard; Qiu, Xinyi; Davies, Llinos; Williams, Hannah; Scanlon, Jeremy; Davies, Gwyneth; Mackay, Callum; Lewis, Joanne; Rees, Stephanie; Null, Null; Oblak, Metod; Popescu, Monica; Thankachen, Mini; Null, Null; Higham, Andrew; Simpson, Kerry; Craig, Jayne; Null, Null; Baruah, Rosie; Morris, Sheila; Ferguson, Susie; Shepherd, Amy; Null, Null; Moore, Luke Stephen Prockter; Vizcaychipi, Marcela Paola; de Almeida Martins, Laura Gomes; Carungcong, Jaime; Null, Null; Ali, Inthakab Ali Mohamed; Beaumont, Karen; Blunt, Mark; Coton, Zoe; Curgenven, Hollie; Elsaadany, Mohamed; Fernandes, Kay; Mohamed Ally, Sameena; Rangarajan, Harini; Sarathy, Varun; Selvanayagam, Sivarupan; Vedage, Dave; White, Matthew; Null, Null; Gill, Mandy; Paul, Paul; Ratnam, Valli; Shelton, Sarah; Wynter, Inez; Null, Null; Carmody, Siobhain; Page, Valerie Joan; Null, Null; Beith, Claire Marie; Black, Karen; Clements, Suzanne; Morrison, Alan; Strachan, Dominic; Taylor, Margaret; Clarkson, Michelle; D'Sylva, Stuart; Norman, Kathryn; Null, Null; Auld, Fiona; Donnachie, Joanne; Edmond, Ian; Prentice, Lynn; Runciman, Nikole; Salutous, Dario; Symon, Lesley; Todd, Anne; Turner, Patricia; Short, Abigail; Sweeney, Laura; Murdoch, Euan; Senaratne, Dhaneesha; Null, Null; Hill, Michaela; Kannan, Thogulava; Wild, Laura; Null, Null; Crawley, Rikki; Crew, Abigail; Cunningham, Mishell; Daniels, Allison; Harrison, Laura; Hope, Susan; Inweregbu, Ken; Jones, Sian; Lancaster, Nicola; Matthews, Jamie; Nicholson, Alice; Wray, Gemma; Null, Null; Langton, Helen; Prout, Rachel; Watters, Malcolm; Novis, Catherine; Null, Null; Barron, Anthony; Collins, Ciara; Kaul, Sundeep; Passmore, Heather; Prendergast, Claire; Reed, Anna; Rogers, Paula; Shokkar, Rajvinder; Woodruff, Meriel; Middleton, Hayley; Polgar, Oliver; Nolan, Claire; Thwaites, Vicky; Mahay, Kanta; Null, Null; Collier, Dawn; Hormis, Anil; Maynard, Victoria; Graham, Cheryl; Walker, Rachel; Null, Null; Knights, Ellen; Price, Alicia; Thomas, Alice; Thorpe, Chris; Null, Null; Behan, Teresa; Burnett, Caroline; Hatton, Jonathan; Heeney, Elaine; Mitra, Atideb; Newton, Maria; Pollard, Rachel; Stead, Rachael; Null, Null; Amin, Vishal; Anastasescu, Elena; Anumakonda, Vikram; Karthik, Komala; Kausar, Rizwana; Reid, Karen; Smith, Jacqueline; Imeson-Wood, Janet; Null, Null; Brown, Alison; Crickmore, Vikki; Debreceni, Gabor; Wilkins, Joy; Nicol, Liz; Null, Null; Khaliq, Waqas; Reece-Anthony, Rosie; Birt, Mark; Null, Null; Ghosh, Alison; Williams, Emma; Null, Null; Allen, Louise; Beranova, Eva; Crisp, Nikki; Deery, Joanne; Hazelton, Tracy; Knight, Alicia; Price, Carly; Tilbey, Sorrell; Turki, Salah; Turney, Sharon; Null, Null; Cooper, Joshua; Finch, Cheryl; Liderth, Sarah; Quinn, Alison; Waddington, Natalia; Null, Null; Coventry, Tina; Fowler, Susan; Macmahon, Michael; Mcgregor, Amanda; Null, Null; Cowley, Anne; Highgate, Judith; Null, Null; Brown, Alison; Gregory, Jane; O'Connell, Susan; Smith, Tim; Barberis, Luigi; Null, Null; Gopal, Shameer; Harris, Nichola; Lake, Victoria; Metherell, Stella; Radford, Elizabeth; Null, Null; Daniel, Amelia; Finn, Joanne; Saha, Rajnish; White, Nikki; Easthope, Amy; Null, Null; Donnison, Phil; Trim, Fiona; Eapen, Beena; Null, Null; Birch, Jenny; Bough, Laura; Goodsell, Josie; Tutton, Rebecca; Williams, Patricia; Williams, Sarah; Winter-Goodwin, Barbara; Null, Null; Nichol, Ailstair; Brickell, Kathy; Smyth, Michelle; Murphy, Lorna; Null, Null; Coetzee, Samantha; Gales, Alistair; Otahal, Igor; Raj, Meena; Sell, Craig; Null, Null; Hilltout, Paula; Evitts, Jayne; Tyler, Amanda; Waldron, Joanne; Null, Null; Beesley, Kate; Board, Sarah; Kubisz-Pudelko, Agnieszka; Lewis, Alison; Perry, Jess; Pippard, Lucy; Wood, Di; Buckley, Clare; Null, Null; Barry, Peter; Flint, Neil; Rekha, Patel; Hales, Dawn; Null, Null; Bunni, Lara; Jennings, Claire; Latif, Monica; Marshall, Rebecca; Subramanian, Gayathri; Null, Null; Mcguigan, Peter J.; Wasson, Christopher; Finn, Stephanie; Green, Jackie; Collins, Erin; King, Bernadette; Null, Null; Campbell, Andy; Smuts, Sara; Duffield, Joseph; Smith, Oliver; Mallon, Lewis; Watkins, Claire; Null, Null; Botfield, Liam; Butler, Joanna; Dexter, Catherine; Fletcher, Jo; Garg, Atul; Kuravi, Aditya; Ranga, Poonam; Virgilio, Emma; Null, Null; Belagodu, Zakaula; Fuller, Bridget; Gherman, Anca; Olufuwa, Olumide; Paramsothy, Remi; Stuart, Carmel; Oakley, Naomi; Kamundi, Charlotte; Tyl, David; Collins, Katy; Silva, Pedro; Taylor, June; King, Laura; Coates, Charlotte; Crowley, Maria; Wakefield, Phillipa; Beadle, Jane; Johnson, Laura; Sargeant, Janet; Anderson, Madeleine; Null, Null; Brady, Ailbhe; Chan, Rebekah; Little, Jeff; Mcivor, Shane; Prady, Helena; Whittle, Helen; Mathew, Bijoy; Null, Null; Attwood, Ben; Parsons, Penny; Null, Null; Ward, Geraldine; Bremmer, Pamela; Null, Null; Joe, West; Tracy, Baird; Jim, Ruddy; Null, Null; Davies, Ellie; Roche, Lisa; Sathe, Sonia; Null, Null; Dennis, Catherine; Mcgregor, Alastair; Parris, Victoria; Srikaran, Sinduya; Sukha, Anisha; Null, Null; Campbell, Rachael; Clarke, Noreen; Whiteside, Jonathan; Mascarenhas, Mairi; Donaldson, Avril; Matheson, Joanna; Barrett, Fiona; O'Hara, Marianne; Okeefe, Laura; Bradley, Clare; Null, Null; Eastgate-Jackson, Christine; Filipe, Helder; Martin, Daniel; Maharajh, Amitaa; Garcia, Sara Mingo; Pakou, Glykeria; De Neef, Mark; Null, Null; Dent, Kathy; Horsley, Elizabeth; Akhtar, Muhammad Nauman; Pearson, Sandra; Potoczna, Dorota; Spencer, Sue; Null, Null; Clapham, Melanie; Harper, Rosemary; Poultney, Una; Rice, Polly; Smith, Tim; Mutch, Rachel; Barberis, Luigi; Null, Null; Armstrong, Lisa; Bates, Hayley; Dooks, Emma; Farquhar, Fiona; Hairsine, Brigid; Mcparland, Chantal; Packham, Sophie; Null, Null; Bi, Rehana; Scholefield, Barney; Ashton, Lydia; Null, Null; George, Linsha; Twiss, Sophie; Wright, David; Null, Null; Chablani, Manish; Kirkby, Amy; Netherton, Kimberley; Null, Null; Davies, Kim; O'Brien, Linda; Omar, Zohra; Otahal, Igor; Perkins, Emma; Lewis, Tracy; Sutherland, Isobel; Null, Null; Burns, Karen; Higham, Andrew; Null, Null; Chandler, Ben; Elliott, Kerry; Mallinson, Janine; Turnbull, Alison; Null, Null; Gondo, Prisca; Hadebe, Bernard; Kayani, Abdul; Masunda, Bridgett; Null, Null; Anderson, Taya; Hawcutt, Dan; O'Malley, Laura; Rad, Laura; Rogers, Naomi; Saunderson, Paula; Allison, Kathryn Sian; Afolabi, Deborah; Whitbread, Jennifer; Jones, Dawn; Dore, Rachael; Null, Null; Halkes, Matthew; Mercer, Pauline; Thornton, Lorraine; Null, Null; Dawson, Joy; Garrioch, Sweyn; Tolson, Melanie; Aldridge, Jonathan; Null, Null; Kapoor, Ritoo; Loader, David; Castle, Karen; Null, Null; Humphreys, Sally; Tampsett, Ruth; Null, Null; Mackintosh, Katherine; Ayers, Amanda; Harrison, Wendy; North, Julie; Null, Null; Allibone, Suzanne; Genetu, Roman; Kasipandian, Vidya; Patel, Amit; Mac, Ainhi; Murphy, Anthony; Mahjoob, Parisa; Nazari, Roonak; Worsley, Lucy; Fagan, Andrew; Null, Null; Bemand, Thomas; Black, Ethel; Dela Rosa, Arnold; Howle, Ryan; Jhanji, Shaman; Baikady, Ravishankar Rao; Tatham, Kate Colette; Thomas, Benjamin; Null, Null; Bell, Dina; Boyle, Rosalind; Douglas, Katie; Glass, Lynn; Lee, Emma; Lennon, Liz; Rattray, Austin; Null, Null; Taylor, Abigail; Hughes, Rachel Anne; Thomas, Helen; Rees, Alun; Duskova, Michaela; Phipps, Janet; Brooks, Suzanne; Edwards, Michelle; Null, Null; Parris, Victoria; Quaid, Sheena; Watson, Ekaterina; Null, Null; Brayne, Adam; Fisher, Emma; Hunt, Jane; Jackson, Peter; Kaye, Duncan; Love, Nicholas; Parkin, Juliet; Tuckey, Victoria; van Koutrik, Lynne; Carter, Sasha; Andrew, Benedict; Findlay, Louise; Adams, Katie; Null, Null; Service, Jen; Williams, Alison; Cheyne, Claire; Saunderson, Anne; Moultrie, Sam; Odam, Miranda; Null, Null; Hall, Kathryn; Mapfunde, Isheunesu; Willis, Charlotte; Lyon, Alex; Null, Null; Sri-Chandana, Chunda; Scherewode, Joslan; Stephenson, Lorraine; Marsh, Sarah; Null, Null; Brealey, David; Hardy, John; Houlden, Henry; Moncur, Eleanor; Raith, Eamon; Tariq, Ambreen; Tucci, Arianna; Null, Null; Hobrok, Maria; Loosley, Ronda; Mcguinness, Heather; Tench, Helen; Wolf-Roberts, Rebecca; Null, Null; Irvine, Val; Shelley, Benjamin; Null, Null; Easthope, Amy; Gorman, Claire; Gupta, Abhinav; Timlick, Elizabeth; Brady, Rebecca; Null, Null; Milligan, Barry; Null, Null; Bellini, Arianna; Bryant, Jade; Mayer, Anton; Pickard, Amy; Roe, Nicholas; Sowter, Jason; Howlett, Alex; Null, Null; Fidler, Katy; Tagliavini, Emma; Donnelly, Kevin; Null, Null; Shelton, Janie F.; Shastri, Anjali J.; Ye, Chelsea; Weldon, Catherine H.; Filshtein-Sonmez, Teresa; Coker, Daniella; Symons, Antony; Esparza-Gordillo, Jorge; Aslibekyan, Stella; Auton, Adam; Null, Null; Pathak, Gita A.; Karjalainen, Juha; Stevens, Christine; Andrews, Shea J.; Kanai, Masahiro; Cordioli, Mattia; Polimanti, Renato; Pirinen, Matti; Harerimana, Nadia; Veerapen, Kumar; Wolford, Brooke; Nguyen, Huy; Solomonson, Matthew; Liao, Rachel G.; Chwialkowska, Karolina; Trankiem, Amy; Balaconis, Mary K.; Hayward, Caroline; Richmond, Anne; Campbell, Archie; Morris, Marcela; Fawns-Ritchie, Chloe; Glessner, Joseph T.; Shaw, Douglas M.; Chang, Xiao; Polikowski, Hannah; Petty, Lauren E.; Chen, Hung-Hsin; Wanying, Zhu; Hakonarson, Hakon; Porteous, David J.; Below, Jennifer; North, Kari; Mccormick, Joseph B.; Timmers, Paul R. H. J.; Wilson, James F.; Tenesa, Albert; D'Mellow, Kenton; Kerr, Shona M.; Niemi, Mari E. K.; Nkambul, Lindokuhle; von Hohenstaufen, Kathrin Aprile; Sobh, Ali; Eltoukhy, Madonna M.; Yassen, Amr M.; Hegazy, Mohamed A. F.; Okasha, Kamal; Eid, Mohammed A.; Moahmed, Hanteera S.; Shahin, Doaa; El-Sherbiny, Yasser M.; Elhadidy, Tamer A.; Abd Elghafar, Mohamed S.; El-Jawhari, Jehan J.; Mohamed, Attia A. S.; Elnagdy, Marwa H.; Samir, Amr; Abdel-Aziz, Mahmoud; Khafaga, Walid T.; El-Lawaty, Walaa M.; Torky, Mohamed S.; El-shanshory, Mohamed R.; Batini, Chiara; Lee, Paul H.; Shrine, Nick; Williams, Alexander T.; Tobin, Martin D.; Guyatt, Anna L.; John, Catherine; Packer, Richard J.; Ali, Altaf; Free, Robert C.; Wang, Xueyang; Wain, Louise V.; Hollox, Edward J.; Venn, Laura D.; Bee, Catherine E.; Adams, Emma L.; Niavarani, Ahmadreza; Sharififard, Bahareh; Aliannejad, Rasoul; Amirsavadkouhi, Ali; Naderpour, Zeinab; Tadi, Hengameh Ansari; Aleagha, Afshar Etemadi; Ahmadi, Saeideh; Moghaddam, Seyed Behrooz Mohseni; Adamsara, Alireza; Saeedi, Morteza; Abdollahi, Hamed; Hosseini, Abdolmajid; Chariyavilaskul, Pajaree; Chamnanphon, Monpat; Suttichet, Thitima B.; Shotelersuk, Vorasuk; Pongpanich, Monnat; Phokaew, Chureerat; Chetruengchai, Wanna; Jantarabenjakul, Watsamon; Putchareon, Opass; Torvorapanit, Pattama; Puthanakit, Thanyawee; Suchartlikitwong, Pintip; Hirankarn, Nattiya; Nilaratanakul, Voraphoj; Sodsai, Pimpayao; Brumpton, Ben M.; Hveem, Kristian; Willer, Cristen; Zhou, Wei; Rogne, Tormod; Solligard, Erik; Åsvold, Bjørn Olav; Abedalthagafi, Malak; Alaamery, Manal; Alqahtani, Saleh; Barakeh, Duna; Al Harthi, Fawz; Alsolm, Ebtehal; Safieh, Leen Abu; Alowayn, Albandary M.; Alqubaishi, Fatimah; Al Mutairi, Amal; Mangul, Serghei; Alshareef, Abdulraheem; Sawaji, Mona; Almutairi, Mansour; Aljawini, Nora; Albesher, Nour; Arabi, Yaseen M.; Mahmoud, Ebrahim S.; Khattab, Amin K.; Halawani, Roaa T.; Alahmadey, Ziab Z.; Albakri, Jehad K.; Felemban, Walaa A.; Suliman, Bandar A.; Hasanato, Rana; Al-Awdah, Laila; Alghamdi, Jahad; Alzahrani, Deema; Aljohani, Sameera; Al-Afghani, Hani; Alrashed, May; Aldhawi, Nouf; Albardis, Hadeel; Alkwai, Sarah; Alswailm, Moneera; Almalki, Faisal; Albeladi, Maha; Almohammed, Iman; Barhoush, Eman; Albader, Anoud; Massadeh, Salam; Almalik, Abdulaziz; Alotaibi, Sara; Alghamdi, Bader; Jung, Junghyun; Fawzy, Mohammad S.; Lee, Yunsung; Magnus, Per; Trogstad, Lill-Iren S.; Helgeland, Øyvind; Harris, Jennifer R.; Mangino, Massimo; Spector, Tim D.; Duncan, Emma; Smieszek, Sandra P.; Przychodzen, Bartlomiej P.; Polymeropoulos, Christos; Polymeropoulos, Vasilios; Polymeropoulos, Mihael H.; Fernandez-Cadenas, Israel; Perez-Tur, Jordi; Llucià-Carol, Laia; Cullell, Natalia; Muiño, Elena; Cárcel-Márquez, Jara; Dediego, Marta L.; Iglesias, Lara Lloret; Planas, Anna M.; Soriano, Alex; Rico, Veronica; Agüero, Daiana; Bedini, Josep L.; Lozano, Francisco; Domingo, Carlos; Robles, Veronica; Ruiz-Jaén, Francisca; Márquez, Leonardo; Gomez, Juan; Coto, Eliecer; Albaiceta, Guillermo M.; García-Clemente, Marta; Dalmau, David; Arranz, Maria J.; Dietl, Beatriz; Serra-Llovich, Alex; Soler, Pere; Colobrán, Roger; Martín-Nalda, Andrea; Martínez, Alba Parra; Bernardo, David; Rojo, Silvia; Fiz-López, Aida; Arribas, Elisa; de la Cal-Sabater, Paloma; Segura, Tomás; González-Villa, Esther; Serrano-Heras, Gemma; Martí-Fàbregas, Joan; Jiménez-Xarrié, Elena; de Felipe Mimbrera, Alicia; Masjuan, Jaime; García-Madrona, Sebastian; Domínguez-Mayoral, Anna; Villalonga, Joan Montaner; Menéndez-Valladares, Paloma; Chasman, Daniel I.; Buring, Julie E.; Ridker, Paul M.; Franco, Giulianini; Sesso, Howard D.; Manson, JoAnn E.; Glessner, Joseph R.; Hakonarson, Hakon; Medina-Gomez, Carolina; Uitterlinden, Andre G.; Ikram, M. Arfan; Kristiansson, Kati; Koskelainen, Sami; Perola, Markus; Donner, Kati; Kivinen, Katja; Palotie, Aarno; Ripatti, Samuli; Ruotsalainen, Sanni; Kaunisto, Mari; Nakanishi, Tomoko; Butler-Laporte, Guillaume; Forgetta, Vincenzo; Morrison, David R.; Ghosh, Biswarup; Laurent, Laetitia; Belisle, Alexandre; Henry, Danielle; Abdullah, Tala; Adeleye, Olumide; Mamlouk, Noor; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Vulesevic, Branka; Bouab, Meriem; Guzman, Charlotte; Petitjean, Louis; Tselios, Chris; Xue, Xiaoqing; Schurr, Erwin; Afilalo, Jonathan; Afilalo, Marc; Oliveira, Maureen; Brenner, Bluma; Lepage, Pierre; Ragoussis, Jiannis; Auld, Daniel; Brassard, Nathalie; Durand, Madeleine; Chassé, Michaël; Kaufmann, Daniel E.; Lathrop, G. Mark; Mooser, Vincent; Richards, J. Brent; Li, Rui; Adra, Darin; Rahmouni, Souad; Georges, Michel; Moutschen, Michel; Misset, Benoit; Darcis, Gilles; Guiot, Julien; Guntz, Julien; Azarzar, Samira; Gofflot, Stéphanie; Beguin, Yves; Claassen, Sabine; Malaise, Olivier; Huynen, Pascale; Meuris, Christelle; Thys, Marie; Jacques, Jessica; Léonard, Philippe; Frippiat, Frederic; Giot, Jean-Baptiste; Sauvage, Anne-Sophie; von Frenckell, Christian; Belhaj, Yasmine; Lambermont, Bernard; Pigazzini, Sara; Nkambule, Lindokuhle; Daya, Michelle; Shortt, Jonathan; Rafaels, Nicholas; Wicks, Stephen J.; Crooks, Kristy; Barnes, Kathleen C.; Gignoux, Christopher R.; Chavan, Sameer; Laisk, Triin; Läll, Kristi; Lepamets, Maarja; Mägi, Reedik; Esko, Tõnu; Reimann, Ene; Milani, Lili; Alavere, Helene; Metsalu, Kristjan; Puusepp, Mairo; Metspalu, Andres; Naaber, Paul; Laane, Edward; Pesukova, Jaana; Peterson, Pärt; Kisand, Kai; Tabri, Jekaterina; Allos, Raili; Hensen, Kati; Starkopf, Joel; Ringmets, Inge; Tamm, Anu; Kallaste, Anne; Bochud, Pierre-Yves; Rivolta, Carlo; Bibert, Stéphanie; Quinodoz, Mathieu; Kamdar, Dhryata; Boillat, Noémie; Nussle, Semira Gonseth; Albrich, Werner; Suh, Noémie; Neofytos, Dionysios; Erard, Véronique; Voide, Cathy; de Cid, Rafael; Galván-Femenía, Iván; Blay, Natalia; Carreras, Anna; Cortés, Beatriz; Farré, Xavier; Sumoy, Lauro; Moreno, Victor; Mercader, Josep Maria; Guindo-Martinez, Marta; Torrents, David; Kogevinas, Manolis; Garcia-Aymerich, Judith; Castaño-Vinyals, Gemma; Dobaño, Carlota; Renieri, Alessandra; Mari, Francesca; Fallerini, Chiara; Daga, Sergio; Benetti, Elisa; Baldassarri, Margherita; Fava, Francesca; Frullanti, Elisa; Valentino, Floriana; Doddato, Gabriella; Giliberti, Annarita; Tita, Rossella; Amitrano, Sara; Bruttini, Mirella; Croci, Susanna; Meloni, Ilaria; Mencarelli, Maria Antonietta; Rizzo, Caterina Lo; Pinto, Anna Maria; Beligni, Giada; Tommasi, Andrea; Di Sarno, Laura; Palmieri, Maria; Carriero, Miriam Lucia; Alaverdian, Diana; Busani, Stefano; Bruno, Raffaele; Vecchia, Marco; Belli, Mary Ann; Picchiotti, Nicola; Sanarico, Maurizio; Gori, Marco; Furini, Simone; Mantovani, Stefania; Ludovisi, Serena; Mondelli, Mario Umberto; Castelli, Francesco; Quiros-Roldan, Eugenia; Antoni, Melania Degli; Zanella, Isabella; Vaghi, Massimo; Rusconi, Stefano; Siano, Matteo; Montagnani, Francesca; Emiliozzi, Arianna; Fabbiani, Massimiliano; Rossetti, Barbara; Bargagli, Elena; Bergantini, Laura; D'Alessandro, Miriana; Cameli, Paolo; Bennett, David; Anedda, Federico; Marcantonio, Simona; Scolletta, Sabino; Franchi, Federico; Mazzei, Maria Antonietta; Guerrini, Susanna; Conticini, Edoardo; Cantarini, Luca; Frediani, Bruno; Tacconi, Danilo; Spertilli, Chiara; Feri, Marco; Donati, Alice; Scala, Raffaele; Guidelli, Luca; Spargi, Genni; Corridi, Marta; Nencioni, Cesira; Croci, Leonardo; Bandini, Maria; Caldarelli, Gian Piero; Piacentini, Paolo; Desanctis, Elena; Cappelli, Silvia; Canaccini, Anna; Verzuri, Agnese; Anemoli, Valentina; Ognibene, Agostino; Pancrazzi, Alessandro; Lorubbio, Maria; D'Arminio Monforte, Antonella; Miraglia, Federica Gaia; Girardis, Massimo; Venturelli, Sophie; Cossarizza, Andrea; Antinori, Andrea; Vergori, Alessandra; Gabrieli, Arianna; Riva, Agostino; Francisci, Daniela; Schiaroli, Elisabetta; Paciosi, Francesco; Scotton, Pier Giorgio; Andretta, Francesca; Panese, Sandro; Scaggiante, Renzo; Gatti, Francesca; Parisi, Saverio Giuseppe; Baratti, Stefano; Della Monica, Matteo; Piscopo, Carmelo; Capasso, Mario; Russo, Roberta; Andolfo, Immacolata; Iolascon, Achille; Fiorentino, Giuseppe; Carella, Massimo; Castori, Marco; Merla, Giuseppe; Squeo, Gabriella Maria; Aucella, Filippo; Raggi, Pamela; Marciano, Carmen; Perna, Rita; Bassetti, Matteo; Di Biagio, Antonio; Sanguinetti, Maurizio; Masucci, Luca; Valente, Serafina; Mandalà, Marco; Giorli, Alessia; Salerni, Lorenzo; Zucchi, Patrizia; Parravicini, Pierpaolo; Menatti, Elisabetta; Trotta, Tullio; Giannattasio, Ferdinando; Coiro, Gabriella; Lena, Fabio; Coviello, Domenico A.; Mussini, Cristina; Martinelli, Enrico; Mancarella, Sandro; Tavecchia, Luisa; Crotti, Lia; Gabbi, Chiara; Rizzi, Marco; Maggiolo, Franco; Ripamonti, Diego; Bachetti, Tiziana; La Rovere, Maria Teresa; Sarzi-Braga, Simona; Bussotti, Maurizio; Ceri, Stefano; Pinoli, Pietro; Raimondi, Francesco; Biscarini, Filippo; Stella, Alessandra; Zguro, Kristina; Capitani, Katia; Suardi, Claudia; Dei, Simona; Parati, Gianfranco; Ravaglia, Sabrina; Artuso, Rosangela; Bottà, Giordano; Di Domenico, Paolo; Rancan, Ilaria; Perrella, Antonio; Bianchi, Francesco; Romani, Davide; Bergomi, Paola; Catena, Emanuele; Colombo, Riccardo; Tanfoni, Marco; Vincenti, Antonella; Ferri, Claudio; Grassi, Davide; Pessina, Gloria; Tumbarello, Mario; Di Pietro, Massimo; Sabrina, Ravaglia; Luchi, Sauro; Barbieri, Chiara; Acquilini, Donatella; Andreucci, Elena; Segala, Francesco Vladimiro; Tiseo, Giusy; Falcone, Marco; Lista, Mirjam; Poscente, Monica; De Vivo, Oreste; Petrocelli, Paola; Guarnaccia, Alessandra; Baroni, Silvia; Smith, Albert V.; Boughton, Andrew P.; Li, Kevin W.; Lefaive, Jonathon; Annis, Aubrey; Justice, Anne E.; Mirshahi, Tooraj; Chittoor, Geetha; Josyula, Navya Shilpa; Kosmicki, Jack A.; Ferreira, Manuel A. R.; Leader, Joseph B.; Carey, Dave J.; Gass, Matthew C.; Horowitz, Julie E.; Cantor, Michael N.; Yadav, Ashish; Baras, Aris; Abecasis, Goncalo R.; van Heel, David A.; Hunt, Karen A.; Mason, Dan; Huang, Qin Qin; Finer, Sarah; Trivedi, Bhavi; Griffiths, Christopher J.; Martin, Hilary C.; Wright, John; Trembath, Richard C.; Soranzo, Nicole; Zhao, Jing Hua; Butterworth, Adam S.; Danesh, John; Di Angelantonio, Emanuele; Franke, Lude; Boezen, Marike; Deelen, Patrick; Claringbould, Annique; Lopera, Esteban; Warmerdam, Robert; Vonk, Judith M.; van Blokland, Irene; Lanting, Pauline; Ori, Anil P. S.; Zöllner, Sebastian; Wang, Jiongming; Beck, Andrew; Peloso, Gina; Ho, Yuk-Lam; Sun, Yan V.; Huffman, Jennifer E.; O'Donnell, Christopher J.; Cho, Kelly; Tsao, Phil; Gaziano, J. Michael; Nivard, Michel; de Geus, Eco; Bartels, Meike; Jan Hottenga, Jouke; Weiss, Scott T.; Karlson, Elizabeth W.; Smoller, Jordan W.; Green, Robert C.; Feng, Yen-Chen Anne; Mercader, Josep; Murphy, Shawn N.; Meigs, James B.; Woolley, Ann E.; Perez, Emma F.; Rader, Daniel; Verma, Anurag; Ritchie, Marylyn D.; Li, Binglan; Verma, Shefali S.; Lucas, Anastasia; Bradford, Yuki; Zeberg, Hugo; Frithiof, Robert; Hultström, Michael; Lipcsey, Miklos; Nkambul, Lindo; Tardif, Nicolas; Rooyackers, Olav; Grip, Jonathan; Maricic, Tomislav; Karczewski, Konrad J.; Atkinson, Elizabeth G.; Tsuo, Kristin; Baya, Nikolas; Turley, Patrick; Gupta, Rahul; Callier, Shawneequa; Walters, Raymond K.; Palmer, Duncan S.; Sarma, Gopal; Cheng, Nathan; Lu, Wenhan; Bryant, Sam; Churchhouse, Claire; Cusick, Caroline; Goldstein, Jacqueline I.; King, Daniel; Seed, Cotton; Finucane, Hilary; Martin, Alicia R.; Satterstrom, F. Kyle; Wilson, Daniel J.; Armstrong, Jacob; Rudkin, Justine K.; Band, Gavin; Earle, Sarah G.; Lin, Shang-Kuan; Arning, Nicolas; Crook, Derrick W.; Wyllie, David H.; O'Connell, Anne Marie; Spencer, Chris C. 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F.; Nadkarni, Girish N.; Do, Ron; Hoggart, Clive; Choi, Sam; Underwood, Slayton J.; O'Reilly, Paul; Huckins, Laura M.; Zyndorf, Marissa; Daly, Mark J.; Neale, Benjamin M.; Ganna, Andrea; Fawkes, Angie; Murphy, Lee; Rowan, Kathy; Ponting, Chris P.; Vitart, Veronique; Wilson, James F.; Yang, Jian; Bretherick, Andrew D.; Scott, Richard H.; Hendry, Sara Clohisey; Moutsianas, Loukas; Law, Andy; Caulfield, Mark J.; Baillie, J. Kenneth. - In: NATURE. - ISSN 0028-0836. - 607:7917(2022), pp. 97-103. [10.1038/s41586-022-04576-6]

Whole-genome sequencing reveals host factors underlying critical COVID-19

Capasso, Mario;Russo, Roberta;Andolfo, Immacolata;Iolascon, Achille;
2022

Abstract

: Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
2022
Whole-genome sequencing reveals host factors underlying critical COVID-19 / Kousathanas, Athanasios; Pairo-Castineira, Erola; Rawlik, Konrad; Stuckey, Alex; Odhams, Christopher A.; Walker, Susan; Russell, Clark D.; Malinauskas, Tomas; Wu, Yang; Millar, Jonathan; Shen, Xia; Elliott, Katherine S.; Griffiths, Fiona; Oosthuyzen, Wilna; Morrice, Kirstie; Keating, Sean; Wang, Bo; Rhodes, Daniel; Klaric, Lucija; Zechner, Marie; Parkinson, Nick; Siddiq, Afshan; Goddard, Peter; Donovan, Sally; Maslove, David; Nichol, Alistair; Semple, Malcolm G.; Zainy, Tala; Maleady-Crowe, Fiona; Todd, Linda; Salehi, Shahla; Knight, Julian; Elgar, Greg; Chan, Georgia; Arumugam, Prabhu; Patch, Christine; Rendon, Augusto; Bentley, David; Kingsley, Clare; Kosmicki, Jack A.; Horowitz, Julie E.; Baras, Aris; Abecasis, Goncalo R.; Ferreira, Manuel A. R.; Justice, Anne; Mirshahi, Tooraj; Oetjens, Matthew; Rader, Daniel J.; Ritchie, Marylyn D.; Verma, Anurag; Fowler, Tom A.; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; Mcauley, Danny; Montgomery, Hugh; Openshaw, Peter J. M.; Elliott, Paul; Walsh, Timothy; Tenesa, Albert; Null, Null; Null, Null; Baillie, J. Kenneth; Begg, Colin; Clohisey Hendry, Sara; Hinds, Charles; Horby, Peter; Knight, Julian; Ling, Lowell; Maslove, David; Mcauley, Danny; Millar, Johnny; Montgomery, Hugh; Nichol, Alistair; Openshaw, Peter J. M.; Pereira, Alexandre C.; Ponting, Chris P.; Rowan, Kathy; Semple, Malcolm G.; Shankar-Hari, Manu; Summers, Charlotte; Walsh, Timothy; Null, Null; Aravindan, Latha; Armstrong, Ruth; Biggs, Heather; Boz, Ceilia; Brown, Adam; Clark, Richard; Coutts, Audrey; Coyle, Judy; Cullum, Louise; Das, Sukamal; Day, Nicky; Donnelly, Lorna; Duncan, Esther; Fawkes, Angie; Finernan, Paul; Fourman, Max Head; Furlong, Anita; Furniss, James; Gallagher, Bernadette; Gilchrist, Tammy; Golightly, Ailsa; Griffiths, Fiona; Hafezi, Katarzyna; Hamilton, Debbie; Hendry, Ross; Law, Andy; Law, Dawn; Law, Rachel; Law, Sarah; Lidstone-Scott, Rebecca; Macgillivray, Louise; Maclean, Alan; Mal, Hanning; Mccafferty, Sarah; Mcmaster, Ellie; Meikle, Jen; Moore, Shona C.; Morrice, Kirstie; Murphy, Lee; Murphy, Sheena; Hellen, Mybaya; Oosthuyzen, Wilna; Zheng, Chenqing; Chen, Jiantao; Parkinson, Nick; Paterson, Trevor; Schon, Katherine; Stenhouse, Andrew; Das, Mihaela; Swets, Maaike; Szoor-McElhinney, Helen; Taneski, Filip; Turtle, Lance; Wackett, Tony; Ward, Mairi; Weaver, Jane; Wrobel, Nicola; Zechner, Marie; Null, Null; Arbane, Gill; Bociek, Aneta; Campos, Sara; Grau, Neus; Jones, Tim Owen; Lim, Rosario; Marotti, Martina; Ostermann, Marlies; Shankar-Hari, Manu; Whitton, Christopher; Null, Null; Alldis, Zoe; Astin-Chamberlain, Raine; Bibi, Fatima; Biddle, Jack; Blow, Sarah; Bolton, Matthew; Borra, Catherine; Bowles, Ruth; Burton, Maudrian; Choudhury, Yasmin; Collier, David; Cox, Amber; Easthope, Amy; Ebano, Patrizia; Fotiadis, Stavros; Gurasashvili, Jana; Halls, Rosslyn; Hartridge, Pippa; Kallon, Delordson; Kassam, Jamila; Lancoma-Malcolm, Ivone; Matharu, Maninderpal; May, Peter; Mitchelmore, Oliver; Newman, Tabitha; Patel, Mital; Pheby, Jane; Pinzuti, Irene; Prime, Zoe; Prysyazhna, Oleksandra; Shiel, Julian; Taylor, Melanie; Tierney, Carey; Wood, Suzanne; Zak, Anne; Zongo, Olivier; Null, Null; Bonner, Stephen; Hugill, Keith; Jones, Jessica; Liggett, Steven; Headlam, Evie; Null, Null; Bandla, Nageswar; Gellamucho, Minnie; Davies, Michelle; Thompson, Christopher; Null, Null; Abdelrazik, Marwa; Bakthavatsalam, Dhanalakshmi; Elhassan, Munzir; Ganesan, Arunkumar; Haldeos, Anne; Moreno-Cuesta, Jeronimo; Purohit, Dharam; Vincent, Rachel; Xavier, Kugan; Kumar, Rohit; Frater, Alasdair; Saleem, Malik; Carter, David; Jenkins, Samuel; Lamond, Zoe; Wall, Alanna; Null, Null; Fernandez-Roman, Jaime; Hamilton, David O.; Johnson, Emily; Johnston, Brian; Martinez, Maria Lopez; Mulla, Suleman; Shaw, David; Waite, Alicia A. C.; Waugh, Victoria; Welters, Ingeborg D.; Williams, Karen; Null, Null; Cavazza, Anna; Cockrell, Maeve; Corcoran, Eleanor; Depante, Maria; Finney, Clare; Jerome, Ellen; Mcphail, Mark; Nayak, Monalisa; Noble, Harriet; O'Reilly, Kevin; Pappa, Evita; Saha, Rohit; Saha, Sian; Smith, John; Knighton, Abigail; Null, Null; Antcliffe, David; Banach, Dorota; Brett, Stephen; Coghlan, Phoebe; Fernandez, Ziortza; Gordon, Anthony; Rojo, Roceld; Arias, Sonia Sousa; Templeton, Maie; Null, Null; Meredith, Megan; Morris, Lucy; Ryan, Lucy; Clark, Amy; Sampson, Julia; Peters, Cecilia; Dent, Martin; Langley, Margaret; Ashraf, Saima; Wei, Shuying; Andrew, Angela; Null, Null; Bashyal, Archana; Davidson, Neil; Hutton, Paula; Mckechnie, Stuart; Wilson, Jean; Null, Null; Baptista, David; Crowe, Rebecca; Fernandes, Rita; Herdman-Grant, Rosaleen; Joseph, Anna; O'Connor, Denise; Allen, Meryem; Loveridge, Adam; Mckenley, India; Morino, Eriko; Naranjo, Andres; Simms, Richard; Sollesta, Kathryn; Swain, Andrew; Venkatesh, Harish; Khera, Jacyntha; Fox, Jonathan; Null, Null; Andrew, Gillian; Baillie, J. Kenneth; Barclay, Lucy; Callaghan, Marie; Campbell, Rachael; Clark, Sarah; Hope, Dave; Marshall, Lucy; Mcculloch, Corrienne; Briton, Kate; Singleton, Jo; Birch, Sophie; Null, Null; Brimfield, Lutece; Daly, Zoe; Pogson, David; Rose, Steve; Nown, Angela; Null, Null; Battle, Ceri; Brinkworth, Elaine; Harford, Rachel; Murphy, Carl; Newey, Luke; Rees, Tabitha; Williams, Marie; Arnold, Sophie; Null, Null; Polgarova, Petra; Stroud, Katerina; Summers, Charlotte; Meaney, Eoghan; Jones, Megan; Ng, Anthony; Agrawal, Shruti; Pathan, Nazima; White, Deborah; Daubney, Esther; Elston, Kay; Null, Null; Grauslyte, Lina; Hussain, Musarat; Phull, Mandeep; Pogreban, Tatiana; Rosaroso, Lace; Salciute, Erika; Franke, George; Wong, Joanna; George, Aparna; Null, Null; de Gordoa, Laura Ortiz-Ruiz; Peasgood, Emily; Phillips, Claire; Null, Null; Bates, Michelle; Dasgin, Jo; Gill, Jaspret; Nilsson, Annette; Scriven, James; Collins, Amy; Khaliq, Waqas; Gude, Estefania Treus; Null, Null; Delgado, Carlos Castro; Dawson, Deborah; Ding, Lijun; Durrant, Georgia; Ezeobu, Obiageri; Farnell-Ward, Sarah; Harrison, Abiola; Kanu, Rebecca; Leaver, Susannah; Maccacari, Elena; Manna, Soumendu; Saluzzio, Romina Pepermans; Queiroz, Joana; Samakomva, Tinashe; Sicat, Christine; Texeira, Joana; Da Gloria, Edna Fernandes; Lisboa, Ana; Rawlins, John; Mathew, Jisha; Kinch, Ashley; Hurt, William James; Shah, Nirav; Clark, Victoria; Thanasi, Maria; Yun, Nikki; Patel, Kamal; Null, Null; Bennett, Sara; Goodwin, Emma; Jackson, Matthew; Kent, Alissa; Tibke, Clare; Woodyatt, Wiesia; Zaki, Ahmed; Null, Null; Abraheem, Azmerelda; Bamford, Peter; Cawley, Kathryn; Dunmore, Charlie; Faulkner, Maria; Girach, Rumanah; Jeffrey, Helen; Jones, Rhianna; London, Emily; Nagra, Imrun; Nasir, Farah; Sainsbury, Hannah; Smedley, Clare; Null, Null; Patel, Tahera; Smith, Matthew; Chukkambotla, Srikanth; Kazi, Aayesha; Hartley, Janice; Dykes, Joseph; Hijazi, Muhammad; Keith, Sarah; Khan, Meherunnisa; Ryan-Smith, Janet; Springle, Philippa; Thomas, Jacqueline; Truman, Nick; Saad, Samuel; Coleman, Dabheoc; Fine, Christopher; Matt, Roseanna; Gay, Bethan; Dalziel, Jack; Ali, Syamlan; Goodchild, Drew; Harling, Rhiannan; Bhatterjee, Ravi; Goddard, Wendy; Davison, Chloe; Duberly, Stephen; Hargreaves, Jeanette; Bolton, Rachel; Null, Null; Davey, Miriam; Golden, David; Seaman, Rebecca; Null, Null; Cherian, Shiney; Cutler, Sean; Heron, Anne Emma; Roynon-Reed, Anna; Szakmany, Tamas; Williams, Gemma; Richards, Owen; Cheema, Yusuf; Null, Null; Brooke, Hollie; Buckley, Sarah; Suarez, Jose Cebrian; Charlesworth, Ruth; Hansson, Karen; Norris, John; Poole, Alice; Rose, Alastair; Sandhu, Rajdeep; Sloan, Brendan; Smithson, Elizabeth; Thirumaran, Muthu; Wagstaff, Veronica; Metcalfe, Alexandra; Null, Null; Brunton, Mark; Caterson, Jess; Coles, Holly; Frise, Matthew; Rai, Sabi Gurung; Jacques, Nicola; Keating, Liza; Tilney, Emma; Bartley, Shauna; Bhuie, Parminder; Null, Null; Gibson, Sian; Lyle, Amanda; Mcneela, Fiona; Radhakrishnan, Jayachandran; Hughes, Alistair; Null, Null; Yates, Bryan; Reynolds, Jessica; Campbell, Helen; Thompsom, Maria; Dodds, Steve; Duffy, Stacey; Null, Null; Greer, Sandra; Shuker, Karen; Tridente, Ascanio; Null, Null; Khade, Reena; Sundar, Ashok; Tsinaslanidis, George; Null, Null; Birkinshaw, Isobel; Carter, Joseph; Howard, Kate; Ingham, Joanne; Joy, Rosie; Pearson, Harriet; Roche, Samantha; Scott, Zoe; Null, Null; Bancroft, Hollie; Bellamy, Mary; Carmody, Margaret; Daglish, Jacqueline; Moore, Faye; Rhodes, Joanne; Sangombe, Mirriam; Kadiri, Salma; Scriven, James; Null, Null; Croft, Maria; White, Ian; Frost, Victoria; Aquino, Maia; Null, Null; Jha, Rajeev; Krishnamurthy, Vinodh; Lim, Lai; Lim, Li; Null, Null; Combes, Edward; Joefield, Teishel; Monnery, Sonja; Beech, Valerie; Trotman, Sallyanne; Null, Null; Almaden-Boyle, Christine; Austin, Pauline; Cabrelli, Louise; Cole, Stephen; Casey, Matt; Chapman, Susan; Whyte, Clare; Null, Null; Baird, Yolanda; Butler, Aaron; Chadbourn, Indra; Folkes, Linda; Fox, Heather; Gardner, Amy; Gomez, Raquel; Hobden, Gillian; Hodgson, Luke; King, Kirsten; Margarson, Michael; Martindale, Tim; Meadows, Emma; Raynard, Dana; Thirlwall, Yvette; Helm, David; Margalef, Jordi; Null, Null; Criste, Kristine; Cusack, Rebecca; Golder, Kim; Golding, Hannah; Jones, Oliver; Leggett, Samantha; Male, Michelle; Marani, Martyna; Prager, Kirsty; Williams, Toran; Roberts, Belinda; Salmon, Karen; Null, Null; Anderson, Peter; Archer, Katie; Austin, Karen; Davis, Caroline; Durie, Alison; Kelsall, Olivia; Thrush, Jessica; Vigurs, Charlie; Wild, Laura; Wood, Hannah-Louise; Tranter, Helen; Harrison, Alison; Cowley, Nicholas; Mcalindon, Michael; Burtenshaw, Andrew; Digby, Stephen; Low, Emma; Morgan, Aled; Cother, Naiara; Rankin, Tobias; Clayton, Sarah; Mccurdy, Alex; Null, Null; Ahmed, Cecilia; Baines, Balvinder; Clamp, Sarah; Colley, Julie; Haq, Risna; Hayes, Anne; Hulme, Jonathan; Hussain, Samia; Joseph, Sibet; Kumar, Rita; Maqsood, Zahira; Purewal, Manjit; Null, Null; Benham, Leonie; Bradshaw, Zena; Brown, Joanna; Caswell, Melanie; Cupitt, Jason; Melling, Sarah; Preston, Stephen; Slawson, Nicola; Stoddard, Emma; Warden, Scott; Null, Null; Deacon, Bethan; Lynch, Ceri; Pothecary, Carla; Roche, Lisa; Howe, Gwenllian Sera; Singh, Jayaprakash; Turner, Keri; Ellis, Hannah; Stroud, Natalie; Null, Null; Hunt, Jodie; Dearden, Joy; Dobson, Emma; Drummond, Andy; Mulcahy, Michelle; Munt, Sheila; O'Connor, Grainne; Philbin, Jennifer; Rishton, Chloe; Tully, Redmond; Winnard, Sarah; Null, Null; Cathcart, Susanne; Duffy, Katharine; Puxty, Alex; Puxty, Kathryn; Turner, Lynne; Ireland, Jane; Semple, Gary; Null, Null; Long, Kate; Whiteley, Simon; Wilby, Elizabeth; Ogg, Bethan; Null, Null; Cowton, Amanda; Kay, Andrea; Kent, Melanie; Potts, Kathryn; Wilkinson, Ami; Campbell, Suzanne; Brown, Ellen; Null, Null; Melville, Julie; Naisbitt, Jay; Joseph, Rosane; Lazo, Maria; Walton, Olivia; Neal, Alan; Null, Null; Alexander, Peter; Allen, Schvearn; Bradley-Potts, Joanne; Brantwood, Craig; Egan, Jasmine; Felton, Timothy; Padden, Grace; Ward, Luke; Moss, Stuart; Glasgow, Susannah; Null, Null; Abel, Lynn; Brett, Michael; Digby, Brian; Gemmell, Lisa; Hornsby, James; Macgoey, Patrick; O'Neil, Pauline; Price, Richard; Rodden, Natalie; Rooney, Kevin; Sundaram, Radha; Thomson, Nicola; Null, Null; Hopkins, Bridget; Scriven, James; Thrasyvoulou, Laura; Willis, Heather; Null, Null; Clark, Martyn; Coulding, Martina; Jude, Edward; Mccormick, Jacqueline; Mercer, Oliver; Potla, Darsh; Rehman, Hafiz; Savill, Heather; Turner, Victoria; Null, Null; Downes, Charlotte; Holding, Kathleen; Riches, Katie; Hilton, Mary; Hayman, Mel; Subramanian, Deepak; Daniel, Priya; Null, Null; Adanini, Oluronke; Bhatia, Nikhil; Msiska, Maines; Collins, Rebecca; Null, Null; Clement, Ian; Patel, Bijal; Gulati, A.; Hays, Carole; Webster, K.; Hudson, Anne; Webster, Andrea; Stephenson, Elaine; Mccormack, Louise; Slater, Victoria; Nixon, Rachel; Hanson, Helen; Fearby, Maggie; Kelly, Sinead; Bridgett, Victoria; Robinson, Philip; Null, Null; Camsooksai, Julie; Humphrey, Charlotte; Jenkins, Sarah; Reschreiter, Henrik; Wadams, Beverley; Death, Yasmin; Null, Null; Bastion, Victoria; Clarke, Daphene; David, Beena; Kent, Harriet; Lorusso, Rachel; Lubimbi, Gamu; Murdoch, Sophie; Penacerrada, Melchizedek; Thomas, Alastair; Valentine, Jennifer; Vochin, Ana; Wulandari, Retno; Djeugam, Brice; Null, Null; Bell, Gillian; English, Katy; Katary, Amro; Wilcox, Louise; Null, Null; Bruce, Michelle; Connolly, Karen; Duncan, Tracy; Michael, Helen T.; Lindergard, Gabriella; Hey, Samuel; Fox, Claire; Alfonso, Jordan; Durrans, Laura Jayne; Guerin, Jacinta; Blackledge, Bethan; Harris, Jade; Hruska, Martin; Eltayeb, Ayaa; Lamb, Thomas; Hodgkiss, Tracey; Cooper, Lisa; Rothwell, Joanne; Null, Null; Allan, Angela; Anderson, Felicity; Kaye, Callum; Liew, Jade; Medhora, Jasmine; Scott, Teresa; Trumper, Erin; Botello, Adriana; Null, Null; Lankester, Liana; Nikitas, Nikitas; Wells, Colin; Stowe, Bethan; Spencer, Kayleigh; Null, Null; Brandwood, Craig; Smith, Lara; Clark, Richard; Birchall, Katie; Kolakaluri, Laurel; Baines, Deborah; Sukumaran, Anila; Null, Null; Apetri, Elena; Basikolo, Cathrine; Blackledge, Bethan; Catlow, Laura; Charles, Bethan; Dark, Paul; Doonan, Reece; Harris, Jade; Harvey, Alice; Horner, Daniel; Knowles, Karen; Lee, Stephanie; Lomas, Diane; Lyons, Chloe; Marsden, Tracy; Mclaughlan, Danielle; Mcmorrow, Liam; Pendlebury, Jessica; Perez, Jane; Poulaka, Maria; Proudfoot, Nicola; Slaughter, Melanie; Slevin, Kathryn; Taylor, Melanie; Thomas, Vicky; Walker, Danielle; Michael, Angiy; Collis, Matthew; Null, Null; Cosier, Tracey; Millen, Gemma; Richardson, Neil; Schumacher, Natasha; Weston, Heather; Rand, James; Null, Null; Baxter, Nicola; Henderson, Steven; Kennedy-Hay, Sophie; Mcparland, Christopher; Rooney, Laura; Sim, Malcolm; Mccreath, Gordan; Null, Null; Akeroyd, Louise; Bano, Shereen; Bromley, Matt; Gurr, Lucy; Lawton, Tom; Morgan, James; Sellick, Kirsten; Warren, Deborah; Wilkinson, Brian; Mcgowan, Janet; Ledgard, Camilla; Stacey, Amelia; Pye, Kate; Bellwood, Ruth; Bentley, Michael; Null, Null; Bewley, Jeremy; Garland, Zoe; Grimmer, Lisa; Gumbrill, Bethany; Johnson, Rebekah; Sweet, Katie; Webster, Denise; Efford, Georgia; Null, Null; Convery, Karen; Fottrell-Gould, Deirdre; Hudig, Lisa; Keshet-Price, Jocelyn; Randell, Georgina; Stammers, Katie; Null, Null; Bokhari, Maria; Linnett, Vanessa; Lucas, Rachael; Mccormick, Wendy; Ritzema, Jenny; Sanderson, Amanda; Wild, Helen; Null, Null; Rostron, Anthony; Roy, Alistair; Woods, Lindsey; Cornell, Sarah; Wakinshaw, Fiona; Rogerson, Kimberley; Jarmain, Jordan; Null, Null; Parker, Robert; Reddy, Amie; Turner-Bone, Ian; Wilding, Laura; Harding, Peter; Null, Null; Abernathy, Caroline; Foster, Louise; Gratrix, Andrew; Martinson, Vicky; Parkinson, Priyai; Stones, Elizabeth; Carbral-Ortega, Llucia; Null, Null; Bercades, Georgia; Brealey, David; Hass, Ingrid; Maccallum, Niall; Martir, Gladys; Raith, Eamon; Reyes, Anna; Smyth, Deborah; Null, Null; Zitter, Letizia; Benyon, Sarah; Marriott, Suzie; Park, Linda; Keenan, Samantha; Gordon, Elizabeth; Quinn, Helen; Baines, Kizzy; Null, Null; Cagova, Lenka; Fofano, Adama; Garner, Lucie; Holcombe, Helen; Mepham, Sue; Mitchell, Alice Michael; Mwaura, Lucy; Praman, Krithivasan; Vuylsteke, Alain; Zamikula, Julie; Null, Null; Purewal, Bally; Rivers, Vanessa; Bell, Stephanie; Null, Null; Blakemore, Hayley; Borislavova, Borislava; Faulkner, Beverley; Gendall, Emma; Goff, Elizabeth; Hayes, Kati; Thomas, Matt; Worner, Ruth; Smith, Kerry; Stephens, Deanna; Null, Null; Mew, Louise; Mwaura, Esther; Stewart, Richard; Williams, Felicity; Wren, Lynn; Sutherland, Sara-Beth; Null, Null; Bevan, Emily; Martin, Jane; Trodd, Dawn; Watson, Geoff; Wrey Brown, Caroline; Null, Null; Akinkugbe, Olugbenga; Bamford, Alasdair; Beech, Emily; Belfield, Holly; Bell, Michael; Davies, Charlene; Jones, Gareth A. L.; Mchugh, Tara; Meghari, Hamza; O'Neill, Lauran; Peters, Mark J.; Ray, Samiran; Tomas, Ana Luisa; Null, Null; Burn, Iona; Hambrook, Geraldine; Manso, Katarina; Penn, Ruth; Shanmugasundaram, Pradeep; Tebbutt, Julie; Thornton, Danielle; Null, Null; Cole, Jade; Davies, Michelle; Davies, Rhys; Duffin, Donna; Hill, Helen; Player, Ben; Thomas, Emma; Williams, Angharad; Null, Null; Griffin, Denise; Muchenje, Nycola; Mupudzi, Mcdonald; Partridge, Richard; Conyngham, Jo-Anna; Thomas, Rachel; Wright, Mary; Corral, Maria Alvarez; Null, Null; Jacob, Reni; Jones, Cathy; Denmade, Craig; Null, Null; Beavis, Sarah; Dale, Katie; Gascoyne, Rachel; Hawes, Joanne; Pritchard, Kelly; Stevenson, Lesley; Whileman, Amanda; Null, Null; Doble, Patricia; Hutter, Joanne; Pawley, Corinne; Shovelton, Charmaine; Vaida, Marius; Null, Null; Butcher, Deborah; O'Sullivan, Susie; Butterworth-Cowin, Nicola; Null, Null; Ahmad, Norfaizan; Barker, Joann; Bauchmuller, Kris; Bird, Sarah; Cawthron, Kay; Harrington, Kate; Jackson, Yvonne; Kibutu, Faith; Lenagh, Becky; Masuko, Shamiso; Mills, Gary H.; Raithatha, Ajay; Wiles, Matthew; Willson, Jayne; Newell, Helen; Lye, Alison; Nwafor, Lorenza; Jarman, Claire; Rowland-Jones, Sarah; Foote, David; Cole, Joby; Thompson, Roger; Watson, James; Hesseldon, Lisa; Macharia, Irene; Chetam, Luke; Smith, Jacqui; Ford, Amber; Anderson, Samantha; Birchall, Kathryn; Housley, Kay; Walker, Sara; Milner, Leanne; Hanratty, Helena; Trower, Helen; Phillips, Patrick; Oxspring, Simon; Donne, Ben; Null, Null; Jardine, Catherine; Williams, Dewi; Hay, Alasdair; Null, Null; Flanagan, Rebecca; Hughes, Gareth; Latham, Scott; Mckenna, Emma; Anderson, Jennifer; Hull, Robert; Rhead, Kat; Null, Null; Cruz, Carina; Pattison, Natalie; Null, Null; Charnock, Rob; Mcfarland, Denise; Cosgrove, Denise; Null, Null; Ahmed, Ashar; Morris, Anna; Jakkula, Srinivas; Nune, Arvind; Null, Null; Ali, Asifa; Brady, Megan; Dale, Sam; Dance, Annalisa; Gledhill, Lisa; Greig, Jill; Hanson, Kathryn; Holdroyd, Kelly; Home, Marie; Kelly, Diane; Kitson, Ross; Matapure, Lear; Melia, Deborah; Mellor, Samantha; Nortcliffe, Tonicha; Pinnell, Jez; Robinson, Matthew; Shaw, Lisa; Shaw, Ryan; Thomis, Lesley; Wilson, Alison; Wood, Tracy; Bayo, Lee-Ann; Merwaha, Ekta; Ishaq, Tahira; Hanley, Sarah; Null, Null; Deacon, Bethan; Hibbert, Meg; Pothecary, Carla; Tetla, Dariusz; Woodford, Christopher; Durga, Latha; Kennard-Holden, Gareth; Null, Null; Branney, Debbie; Frankham, Jordan; Pitts, Sally; White, Nigel; Null, Null; Laha, Shondipon; Verlander, Mark; Williams, Alexandra; Null, Null; Altabaibeh, Abdelhakim; Alvaro, Ana; Gilbert, Kayleigh; Ma, Louise; Mostoles, Loreta; Parmar, Chetan; Simpson, Kathryn; Jetha, Champa; Booker, Lauren; Pratley, Anezka; Null, Null; Adams, Colene; Agasou, Anita; Arden, Tracie; Bowes, Amy; Boyle, Pauline; Beekes, Mandy; Button, Heather; Capps, Nigel; Carnahan, Mandy; Carter, Anne; Childs, Danielle; Donaldson, Denise; Hard, Kelly; Hurford, Fran; Hussain, Yasmin; Javaid, Ayesha; Jones, James; Jose, Sanal; Leigh, Michael; Martin, Terry; Millward, Helen; Motherwell, Nichola; Rikunenko, Rachel; Stickley, Jo; Summers, Julie; Ting, Louise; Tivenan, Helen; Tonks, Louise; Wilcox, Rebecca; Skinner, Denise; Gaylard, Jane; Mullan, Dee; Newman, Julie; Null, Null; Holland, Maureen; Keenan, Natalie; Lyons, Marc; Wassall, Helen; Marsh, Chris; Mahenthran, Mervin; Carter, Emma; Kong, Thomas; Null, Null; Blackman, Helen; Creagh-Brown, Ben; Donlon, Sinead; Michalak-Glinska, Natalia; Mtuwa, Sheila; Pristopan, Veronika; Salberg, Armorel; Smith, Eleanor; Stone, Sarah; Piercy, Charles; Verula, Jerik; Burda, Dorota; Montaser, Rugia; Harden, Lesley; Mayangao, Irving; Marriott, Cheryl; Bradley, Paul; Harris, Celia; Null, Null; Anderson, Susan; Andrews, Eleanor; Birch, Janine; Collins, Emma; Hammerton, Kate; O'Leary, Ryan; Null, Null; Clark, Michele; Purvis, Sarah; Null, Null; Barber, Russell; Hewitt, Claire; Hilldrith, Annette; Jackson-Lawrence, Karen; Shepardson, Sarah; Wills, Maryanne; Butler, Susan; Tavares, Silvia; Cunningham, Amy; Hindale, Julia; Arif, Sarwat; Null, Null; Bean, Sarah; Burt, Karen; Spivey, Michael; Null, Null; Demetriou, Carrie; Eckbad, Charlotte; Hierons, Sarah; Howie, Lucy; Mitchard, Sarah; Ramos, Lidia; Serrano-Ruiz, Alfredo; White, Katie; Kelly, Fiona; Null, Null; Cristiano, Daniele; Dormand, Natalie; Farzad, Zohreh; Gummadi, Mahitha; Liyanage, Kamal; Patel, Brijesh; Salmi, Sara; Sloane, Geraldine; Thwaites, Vicky; Varghese, Mathew; Zborowski, Anelise C.; Null, Null; Allan, John; Geary, Tim; Houston, Gordon; Meikle, Alistair; O'Brien, Peter; Null, Null; Forsey, Miranda; Kaliappan, Agilan; Nicholson, Anne; Riches, Joanne; Vertue, Mark; Null, Null; Allan, Elizabeth; Darlington, Kate; Davies, Ffyon; Easton, Jack; Kumar, Sumit; Lean, Richard; Menzies, Daniel; Pugh, Richard; Qiu, Xinyi; Davies, Llinos; Williams, Hannah; Scanlon, Jeremy; Davies, Gwyneth; Mackay, Callum; Lewis, Joanne; Rees, Stephanie; Null, Null; Oblak, Metod; Popescu, Monica; Thankachen, Mini; Null, Null; Higham, Andrew; Simpson, Kerry; Craig, Jayne; Null, Null; Baruah, Rosie; Morris, Sheila; Ferguson, Susie; Shepherd, Amy; Null, Null; Moore, Luke Stephen Prockter; Vizcaychipi, Marcela Paola; de Almeida Martins, Laura Gomes; Carungcong, Jaime; Null, Null; Ali, Inthakab Ali Mohamed; Beaumont, Karen; Blunt, Mark; Coton, Zoe; Curgenven, Hollie; Elsaadany, Mohamed; Fernandes, Kay; Mohamed Ally, Sameena; Rangarajan, Harini; Sarathy, Varun; Selvanayagam, Sivarupan; Vedage, Dave; White, Matthew; Null, Null; Gill, Mandy; Paul, Paul; Ratnam, Valli; Shelton, Sarah; Wynter, Inez; Null, Null; Carmody, Siobhain; Page, Valerie Joan; Null, Null; Beith, Claire Marie; Black, Karen; Clements, Suzanne; Morrison, Alan; Strachan, Dominic; Taylor, Margaret; Clarkson, Michelle; D'Sylva, Stuart; Norman, Kathryn; Null, Null; Auld, Fiona; Donnachie, Joanne; Edmond, Ian; Prentice, Lynn; Runciman, Nikole; Salutous, Dario; Symon, Lesley; Todd, Anne; Turner, Patricia; Short, Abigail; Sweeney, Laura; Murdoch, Euan; Senaratne, Dhaneesha; Null, Null; Hill, Michaela; Kannan, Thogulava; Wild, Laura; Null, Null; Crawley, Rikki; Crew, Abigail; Cunningham, Mishell; Daniels, Allison; Harrison, Laura; Hope, Susan; Inweregbu, Ken; Jones, Sian; Lancaster, Nicola; Matthews, Jamie; Nicholson, Alice; Wray, Gemma; Null, Null; Langton, Helen; Prout, Rachel; Watters, Malcolm; Novis, Catherine; Null, Null; Barron, Anthony; Collins, Ciara; Kaul, Sundeep; Passmore, Heather; Prendergast, Claire; Reed, Anna; Rogers, Paula; Shokkar, Rajvinder; Woodruff, Meriel; Middleton, Hayley; Polgar, Oliver; Nolan, Claire; Thwaites, Vicky; Mahay, Kanta; Null, Null; Collier, Dawn; Hormis, Anil; Maynard, Victoria; Graham, Cheryl; Walker, Rachel; Null, Null; Knights, Ellen; Price, Alicia; Thomas, Alice; Thorpe, Chris; Null, Null; Behan, Teresa; Burnett, Caroline; Hatton, Jonathan; Heeney, Elaine; Mitra, Atideb; Newton, Maria; Pollard, Rachel; Stead, Rachael; Null, Null; Amin, Vishal; Anastasescu, Elena; Anumakonda, Vikram; Karthik, Komala; Kausar, Rizwana; Reid, Karen; Smith, Jacqueline; Imeson-Wood, Janet; Null, Null; Brown, Alison; Crickmore, Vikki; Debreceni, Gabor; Wilkins, Joy; Nicol, Liz; Null, Null; Khaliq, Waqas; Reece-Anthony, Rosie; Birt, Mark; Null, Null; Ghosh, Alison; Williams, Emma; Null, Null; Allen, Louise; Beranova, Eva; Crisp, Nikki; Deery, Joanne; Hazelton, Tracy; Knight, Alicia; Price, Carly; Tilbey, Sorrell; Turki, Salah; Turney, Sharon; Null, Null; Cooper, Joshua; Finch, Cheryl; Liderth, Sarah; Quinn, Alison; Waddington, Natalia; Null, Null; Coventry, Tina; Fowler, Susan; Macmahon, Michael; Mcgregor, Amanda; Null, Null; Cowley, Anne; Highgate, Judith; Null, Null; Brown, Alison; Gregory, Jane; O'Connell, Susan; Smith, Tim; Barberis, Luigi; Null, Null; Gopal, Shameer; Harris, Nichola; Lake, Victoria; Metherell, Stella; Radford, Elizabeth; Null, Null; Daniel, Amelia; Finn, Joanne; Saha, Rajnish; White, Nikki; Easthope, Amy; Null, Null; Donnison, Phil; Trim, Fiona; Eapen, Beena; Null, Null; Birch, Jenny; Bough, Laura; Goodsell, Josie; Tutton, Rebecca; Williams, Patricia; Williams, Sarah; Winter-Goodwin, Barbara; Null, Null; Nichol, Ailstair; Brickell, Kathy; Smyth, Michelle; Murphy, Lorna; Null, Null; Coetzee, Samantha; Gales, Alistair; Otahal, Igor; Raj, Meena; Sell, Craig; Null, Null; Hilltout, Paula; Evitts, Jayne; Tyler, Amanda; Waldron, Joanne; Null, Null; Beesley, Kate; Board, Sarah; Kubisz-Pudelko, Agnieszka; Lewis, Alison; Perry, Jess; Pippard, Lucy; Wood, Di; Buckley, Clare; Null, Null; Barry, Peter; Flint, Neil; Rekha, Patel; Hales, Dawn; Null, Null; Bunni, Lara; Jennings, Claire; Latif, Monica; Marshall, Rebecca; Subramanian, Gayathri; Null, Null; Mcguigan, Peter J.; Wasson, Christopher; Finn, Stephanie; Green, Jackie; Collins, Erin; King, Bernadette; Null, Null; Campbell, Andy; Smuts, Sara; Duffield, Joseph; Smith, Oliver; Mallon, Lewis; Watkins, Claire; Null, Null; Botfield, Liam; Butler, Joanna; Dexter, Catherine; Fletcher, Jo; Garg, Atul; Kuravi, Aditya; Ranga, Poonam; Virgilio, Emma; Null, Null; Belagodu, Zakaula; Fuller, Bridget; Gherman, Anca; Olufuwa, Olumide; Paramsothy, Remi; Stuart, Carmel; Oakley, Naomi; Kamundi, Charlotte; Tyl, David; Collins, Katy; Silva, Pedro; Taylor, June; King, Laura; Coates, Charlotte; Crowley, Maria; Wakefield, Phillipa; Beadle, Jane; Johnson, Laura; Sargeant, Janet; Anderson, Madeleine; Null, Null; Brady, Ailbhe; Chan, Rebekah; Little, Jeff; Mcivor, Shane; Prady, Helena; Whittle, Helen; Mathew, Bijoy; Null, Null; Attwood, Ben; Parsons, Penny; Null, Null; Ward, Geraldine; Bremmer, Pamela; Null, Null; Joe, West; Tracy, Baird; Jim, Ruddy; Null, Null; Davies, Ellie; Roche, Lisa; Sathe, Sonia; Null, Null; Dennis, Catherine; Mcgregor, Alastair; Parris, Victoria; Srikaran, Sinduya; Sukha, Anisha; Null, Null; Campbell, Rachael; Clarke, Noreen; Whiteside, Jonathan; Mascarenhas, Mairi; Donaldson, Avril; Matheson, Joanna; Barrett, Fiona; O'Hara, Marianne; Okeefe, Laura; Bradley, Clare; Null, Null; Eastgate-Jackson, Christine; Filipe, Helder; Martin, Daniel; Maharajh, Amitaa; Garcia, Sara Mingo; Pakou, Glykeria; De Neef, Mark; Null, Null; Dent, Kathy; Horsley, Elizabeth; Akhtar, Muhammad Nauman; Pearson, Sandra; Potoczna, Dorota; Spencer, Sue; Null, Null; Clapham, Melanie; Harper, Rosemary; Poultney, Una; Rice, Polly; Smith, Tim; Mutch, Rachel; Barberis, Luigi; Null, Null; Armstrong, Lisa; Bates, Hayley; Dooks, Emma; Farquhar, Fiona; Hairsine, Brigid; Mcparland, Chantal; Packham, Sophie; Null, Null; Bi, Rehana; Scholefield, Barney; Ashton, Lydia; Null, Null; George, Linsha; Twiss, Sophie; Wright, David; Null, Null; Chablani, Manish; Kirkby, Amy; Netherton, Kimberley; Null, Null; Davies, Kim; O'Brien, Linda; Omar, Zohra; Otahal, Igor; Perkins, Emma; Lewis, Tracy; Sutherland, Isobel; Null, Null; Burns, Karen; Higham, Andrew; Null, Null; Chandler, Ben; Elliott, Kerry; Mallinson, Janine; Turnbull, Alison; Null, Null; Gondo, Prisca; Hadebe, Bernard; Kayani, Abdul; Masunda, Bridgett; Null, Null; Anderson, Taya; Hawcutt, Dan; O'Malley, Laura; Rad, Laura; Rogers, Naomi; Saunderson, Paula; Allison, Kathryn Sian; Afolabi, Deborah; Whitbread, Jennifer; Jones, Dawn; Dore, Rachael; Null, Null; Halkes, Matthew; Mercer, Pauline; Thornton, Lorraine; Null, Null; Dawson, Joy; Garrioch, Sweyn; Tolson, Melanie; Aldridge, Jonathan; Null, Null; Kapoor, Ritoo; Loader, David; Castle, Karen; Null, Null; Humphreys, Sally; Tampsett, Ruth; Null, Null; Mackintosh, Katherine; Ayers, Amanda; Harrison, Wendy; North, Julie; Null, Null; Allibone, Suzanne; Genetu, Roman; Kasipandian, Vidya; Patel, Amit; Mac, Ainhi; Murphy, Anthony; Mahjoob, Parisa; Nazari, Roonak; Worsley, Lucy; Fagan, Andrew; Null, Null; Bemand, Thomas; Black, Ethel; Dela Rosa, Arnold; Howle, Ryan; Jhanji, Shaman; Baikady, Ravishankar Rao; Tatham, Kate Colette; Thomas, Benjamin; Null, Null; Bell, Dina; Boyle, Rosalind; Douglas, Katie; Glass, Lynn; Lee, Emma; Lennon, Liz; Rattray, Austin; Null, Null; Taylor, Abigail; Hughes, Rachel Anne; Thomas, Helen; Rees, Alun; Duskova, Michaela; Phipps, Janet; Brooks, Suzanne; Edwards, Michelle; Null, Null; Parris, Victoria; Quaid, Sheena; Watson, Ekaterina; Null, Null; Brayne, Adam; Fisher, Emma; Hunt, Jane; Jackson, Peter; Kaye, Duncan; Love, Nicholas; Parkin, Juliet; Tuckey, Victoria; van Koutrik, Lynne; Carter, Sasha; Andrew, Benedict; Findlay, Louise; Adams, Katie; Null, Null; Service, Jen; Williams, Alison; Cheyne, Claire; Saunderson, Anne; Moultrie, Sam; Odam, Miranda; Null, Null; Hall, Kathryn; Mapfunde, Isheunesu; Willis, Charlotte; Lyon, Alex; Null, Null; Sri-Chandana, Chunda; Scherewode, Joslan; Stephenson, Lorraine; Marsh, Sarah; Null, Null; Brealey, David; Hardy, John; Houlden, Henry; Moncur, Eleanor; Raith, Eamon; Tariq, Ambreen; Tucci, Arianna; Null, Null; Hobrok, Maria; Loosley, Ronda; Mcguinness, Heather; Tench, Helen; Wolf-Roberts, Rebecca; Null, Null; Irvine, Val; Shelley, Benjamin; Null, Null; Easthope, Amy; Gorman, Claire; Gupta, Abhinav; Timlick, Elizabeth; Brady, Rebecca; Null, Null; Milligan, Barry; Null, Null; Bellini, Arianna; Bryant, Jade; Mayer, Anton; Pickard, Amy; Roe, Nicholas; Sowter, Jason; Howlett, Alex; Null, Null; Fidler, Katy; Tagliavini, Emma; Donnelly, Kevin; Null, Null; Shelton, Janie F.; Shastri, Anjali J.; Ye, Chelsea; Weldon, Catherine H.; Filshtein-Sonmez, Teresa; Coker, Daniella; Symons, Antony; Esparza-Gordillo, Jorge; Aslibekyan, Stella; Auton, Adam; Null, Null; Pathak, Gita A.; Karjalainen, Juha; Stevens, Christine; Andrews, Shea J.; Kanai, Masahiro; Cordioli, Mattia; Polimanti, Renato; Pirinen, Matti; Harerimana, Nadia; Veerapen, Kumar; Wolford, Brooke; Nguyen, Huy; Solomonson, Matthew; Liao, Rachel G.; Chwialkowska, Karolina; Trankiem, Amy; Balaconis, Mary K.; Hayward, Caroline; Richmond, Anne; Campbell, Archie; Morris, Marcela; Fawns-Ritchie, Chloe; Glessner, Joseph T.; Shaw, Douglas M.; Chang, Xiao; Polikowski, Hannah; Petty, Lauren E.; Chen, Hung-Hsin; Wanying, Zhu; Hakonarson, Hakon; Porteous, David J.; Below, Jennifer; North, Kari; Mccormick, Joseph B.; Timmers, Paul R. H. J.; Wilson, James F.; Tenesa, Albert; D'Mellow, Kenton; Kerr, Shona M.; Niemi, Mari E. K.; Nkambul, Lindokuhle; von Hohenstaufen, Kathrin Aprile; Sobh, Ali; Eltoukhy, Madonna M.; Yassen, Amr M.; Hegazy, Mohamed A. F.; Okasha, Kamal; Eid, Mohammed A.; Moahmed, Hanteera S.; Shahin, Doaa; El-Sherbiny, Yasser M.; Elhadidy, Tamer A.; Abd Elghafar, Mohamed S.; El-Jawhari, Jehan J.; Mohamed, Attia A. S.; Elnagdy, Marwa H.; Samir, Amr; Abdel-Aziz, Mahmoud; Khafaga, Walid T.; El-Lawaty, Walaa M.; Torky, Mohamed S.; El-shanshory, Mohamed R.; Batini, Chiara; Lee, Paul H.; Shrine, Nick; Williams, Alexander T.; Tobin, Martin D.; Guyatt, Anna L.; John, Catherine; Packer, Richard J.; Ali, Altaf; Free, Robert C.; Wang, Xueyang; Wain, Louise V.; Hollox, Edward J.; Venn, Laura D.; Bee, Catherine E.; Adams, Emma L.; Niavarani, Ahmadreza; Sharififard, Bahareh; Aliannejad, Rasoul; Amirsavadkouhi, Ali; Naderpour, Zeinab; Tadi, Hengameh Ansari; Aleagha, Afshar Etemadi; Ahmadi, Saeideh; Moghaddam, Seyed Behrooz Mohseni; Adamsara, Alireza; Saeedi, Morteza; Abdollahi, Hamed; Hosseini, Abdolmajid; Chariyavilaskul, Pajaree; Chamnanphon, Monpat; Suttichet, Thitima B.; Shotelersuk, Vorasuk; Pongpanich, Monnat; Phokaew, Chureerat; Chetruengchai, Wanna; Jantarabenjakul, Watsamon; Putchareon, Opass; Torvorapanit, Pattama; Puthanakit, Thanyawee; Suchartlikitwong, Pintip; Hirankarn, Nattiya; Nilaratanakul, Voraphoj; Sodsai, Pimpayao; Brumpton, Ben M.; Hveem, Kristian; Willer, Cristen; Zhou, Wei; Rogne, Tormod; Solligard, Erik; Åsvold, Bjørn Olav; Abedalthagafi, Malak; Alaamery, Manal; Alqahtani, Saleh; Barakeh, Duna; Al Harthi, Fawz; Alsolm, Ebtehal; Safieh, Leen Abu; Alowayn, Albandary M.; Alqubaishi, Fatimah; Al Mutairi, Amal; Mangul, Serghei; Alshareef, Abdulraheem; Sawaji, Mona; Almutairi, Mansour; Aljawini, Nora; Albesher, Nour; Arabi, Yaseen M.; Mahmoud, Ebrahim S.; Khattab, Amin K.; Halawani, Roaa T.; Alahmadey, Ziab Z.; Albakri, Jehad K.; Felemban, Walaa A.; Suliman, Bandar A.; Hasanato, Rana; Al-Awdah, Laila; Alghamdi, Jahad; Alzahrani, Deema; Aljohani, Sameera; Al-Afghani, Hani; Alrashed, May; Aldhawi, Nouf; Albardis, Hadeel; Alkwai, Sarah; Alswailm, Moneera; Almalki, Faisal; Albeladi, Maha; Almohammed, Iman; Barhoush, Eman; Albader, Anoud; Massadeh, Salam; Almalik, Abdulaziz; Alotaibi, Sara; Alghamdi, Bader; Jung, Junghyun; Fawzy, Mohammad S.; Lee, Yunsung; Magnus, Per; Trogstad, Lill-Iren S.; Helgeland, Øyvind; Harris, Jennifer R.; Mangino, Massimo; Spector, Tim D.; Duncan, Emma; Smieszek, Sandra P.; Przychodzen, Bartlomiej P.; Polymeropoulos, Christos; Polymeropoulos, Vasilios; Polymeropoulos, Mihael H.; Fernandez-Cadenas, Israel; Perez-Tur, Jordi; Llucià-Carol, Laia; Cullell, Natalia; Muiño, Elena; Cárcel-Márquez, Jara; Dediego, Marta L.; Iglesias, Lara Lloret; Planas, Anna M.; Soriano, Alex; Rico, Veronica; Agüero, Daiana; Bedini, Josep L.; Lozano, Francisco; Domingo, Carlos; Robles, Veronica; Ruiz-Jaén, Francisca; Márquez, Leonardo; Gomez, Juan; Coto, Eliecer; Albaiceta, Guillermo M.; García-Clemente, Marta; Dalmau, David; Arranz, Maria J.; Dietl, Beatriz; Serra-Llovich, Alex; Soler, Pere; Colobrán, Roger; Martín-Nalda, Andrea; Martínez, Alba Parra; Bernardo, David; Rojo, Silvia; Fiz-López, Aida; Arribas, Elisa; de la Cal-Sabater, Paloma; Segura, Tomás; González-Villa, Esther; Serrano-Heras, Gemma; Martí-Fàbregas, Joan; Jiménez-Xarrié, Elena; de Felipe Mimbrera, Alicia; Masjuan, Jaime; García-Madrona, Sebastian; Domínguez-Mayoral, Anna; Villalonga, Joan Montaner; Menéndez-Valladares, Paloma; Chasman, Daniel I.; Buring, Julie E.; Ridker, Paul M.; Franco, Giulianini; Sesso, Howard D.; Manson, JoAnn E.; Glessner, Joseph R.; Hakonarson, Hakon; Medina-Gomez, Carolina; Uitterlinden, Andre G.; Ikram, M. Arfan; Kristiansson, Kati; Koskelainen, Sami; Perola, Markus; Donner, Kati; Kivinen, Katja; Palotie, Aarno; Ripatti, Samuli; Ruotsalainen, Sanni; Kaunisto, Mari; Nakanishi, Tomoko; Butler-Laporte, Guillaume; Forgetta, Vincenzo; Morrison, David R.; Ghosh, Biswarup; Laurent, Laetitia; Belisle, Alexandre; Henry, Danielle; Abdullah, Tala; Adeleye, Olumide; Mamlouk, Noor; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Vulesevic, Branka; Bouab, Meriem; Guzman, Charlotte; Petitjean, Louis; Tselios, Chris; Xue, Xiaoqing; Schurr, Erwin; Afilalo, Jonathan; Afilalo, Marc; Oliveira, Maureen; Brenner, Bluma; Lepage, Pierre; Ragoussis, Jiannis; Auld, Daniel; Brassard, Nathalie; Durand, Madeleine; Chassé, Michaël; Kaufmann, Daniel E.; Lathrop, G. Mark; Mooser, Vincent; Richards, J. Brent; Li, Rui; Adra, Darin; Rahmouni, Souad; Georges, Michel; Moutschen, Michel; Misset, Benoit; Darcis, Gilles; Guiot, Julien; Guntz, Julien; Azarzar, Samira; Gofflot, Stéphanie; Beguin, Yves; Claassen, Sabine; Malaise, Olivier; Huynen, Pascale; Meuris, Christelle; Thys, Marie; Jacques, Jessica; Léonard, Philippe; Frippiat, Frederic; Giot, Jean-Baptiste; Sauvage, Anne-Sophie; von Frenckell, Christian; Belhaj, Yasmine; Lambermont, Bernard; Pigazzini, Sara; Nkambule, Lindokuhle; Daya, Michelle; Shortt, Jonathan; Rafaels, Nicholas; Wicks, Stephen J.; Crooks, Kristy; Barnes, Kathleen C.; Gignoux, Christopher R.; Chavan, Sameer; Laisk, Triin; Läll, Kristi; Lepamets, Maarja; Mägi, Reedik; Esko, Tõnu; Reimann, Ene; Milani, Lili; Alavere, Helene; Metsalu, Kristjan; Puusepp, Mairo; Metspalu, Andres; Naaber, Paul; Laane, Edward; Pesukova, Jaana; Peterson, Pärt; Kisand, Kai; Tabri, Jekaterina; Allos, Raili; Hensen, Kati; Starkopf, Joel; Ringmets, Inge; Tamm, Anu; Kallaste, Anne; Bochud, Pierre-Yves; Rivolta, Carlo; Bibert, Stéphanie; Quinodoz, Mathieu; Kamdar, Dhryata; Boillat, Noémie; Nussle, Semira Gonseth; Albrich, Werner; Suh, Noémie; Neofytos, Dionysios; Erard, Véronique; Voide, Cathy; de Cid, Rafael; Galván-Femenía, Iván; Blay, Natalia; Carreras, Anna; Cortés, Beatriz; Farré, Xavier; Sumoy, Lauro; Moreno, Victor; Mercader, Josep Maria; Guindo-Martinez, Marta; Torrents, David; Kogevinas, Manolis; Garcia-Aymerich, Judith; Castaño-Vinyals, Gemma; Dobaño, Carlota; Renieri, Alessandra; Mari, Francesca; Fallerini, Chiara; Daga, Sergio; Benetti, Elisa; Baldassarri, Margherita; Fava, Francesca; Frullanti, Elisa; Valentino, Floriana; Doddato, Gabriella; Giliberti, Annarita; Tita, Rossella; Amitrano, Sara; Bruttini, Mirella; Croci, Susanna; Meloni, Ilaria; Mencarelli, Maria Antonietta; Rizzo, Caterina Lo; Pinto, Anna Maria; Beligni, Giada; Tommasi, Andrea; Di Sarno, Laura; Palmieri, Maria; Carriero, Miriam Lucia; Alaverdian, Diana; Busani, Stefano; Bruno, Raffaele; Vecchia, Marco; Belli, Mary Ann; Picchiotti, Nicola; Sanarico, Maurizio; Gori, Marco; Furini, Simone; Mantovani, Stefania; Ludovisi, Serena; Mondelli, Mario Umberto; Castelli, Francesco; Quiros-Roldan, Eugenia; Antoni, Melania Degli; Zanella, Isabella; Vaghi, Massimo; Rusconi, Stefano; Siano, Matteo; Montagnani, Francesca; Emiliozzi, Arianna; Fabbiani, Massimiliano; Rossetti, Barbara; Bargagli, Elena; Bergantini, Laura; D'Alessandro, Miriana; Cameli, Paolo; Bennett, David; Anedda, Federico; Marcantonio, Simona; Scolletta, Sabino; Franchi, Federico; Mazzei, Maria Antonietta; Guerrini, Susanna; Conticini, Edoardo; Cantarini, Luca; Frediani, Bruno; Tacconi, Danilo; Spertilli, Chiara; Feri, Marco; Donati, Alice; Scala, Raffaele; Guidelli, Luca; Spargi, Genni; Corridi, Marta; Nencioni, Cesira; Croci, Leonardo; Bandini, Maria; Caldarelli, Gian Piero; Piacentini, Paolo; Desanctis, Elena; Cappelli, Silvia; Canaccini, Anna; Verzuri, Agnese; Anemoli, Valentina; Ognibene, Agostino; Pancrazzi, Alessandro; Lorubbio, Maria; D'Arminio Monforte, Antonella; Miraglia, Federica Gaia; Girardis, Massimo; Venturelli, Sophie; Cossarizza, Andrea; Antinori, Andrea; Vergori, Alessandra; Gabrieli, Arianna; Riva, Agostino; Francisci, Daniela; Schiaroli, Elisabetta; Paciosi, Francesco; Scotton, Pier Giorgio; Andretta, Francesca; Panese, Sandro; Scaggiante, Renzo; Gatti, Francesca; Parisi, Saverio Giuseppe; Baratti, Stefano; Della Monica, Matteo; Piscopo, Carmelo; Capasso, Mario; Russo, Roberta; Andolfo, Immacolata; Iolascon, Achille; Fiorentino, Giuseppe; Carella, Massimo; Castori, Marco; Merla, Giuseppe; Squeo, Gabriella Maria; Aucella, Filippo; Raggi, Pamela; Marciano, Carmen; Perna, Rita; Bassetti, Matteo; Di Biagio, Antonio; Sanguinetti, Maurizio; Masucci, Luca; Valente, Serafina; Mandalà, Marco; Giorli, Alessia; Salerni, Lorenzo; Zucchi, Patrizia; Parravicini, Pierpaolo; Menatti, Elisabetta; Trotta, Tullio; Giannattasio, Ferdinando; Coiro, Gabriella; Lena, Fabio; Coviello, Domenico A.; Mussini, Cristina; Martinelli, Enrico; Mancarella, Sandro; Tavecchia, Luisa; 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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/986156
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