: The RET receptor tyrosine kinase is physiologically stimulated by growth factors belonging to the glial cell line-derived neurotrophic factor (GDNF) family (GFLs) and by the growth differentiation factor-15 (GDF15) cytokine. RET plays a critical role in normal development as well as in various human tumors and developmental disorders. This review focuses on mechanisms of RET signaling and their alterations in human diseases.
Mechanisms of RET mediated signal transduction / Carlomagno, Francesca; Moccia, Marialuisa; Federico, Giorgia; Santoro, Massimo. - In: ENDOCRINE-RELATED CANCER. - ISSN 1351-0088. - (2024). [10.1530/ERC-24-0131]
Mechanisms of RET mediated signal transduction
Carlomagno, Francesca;Moccia, Marialuisa;Federico, Giorgia;Santoro, Massimo
2024
Abstract
: The RET receptor tyrosine kinase is physiologically stimulated by growth factors belonging to the glial cell line-derived neurotrophic factor (GDNF) family (GFLs) and by the growth differentiation factor-15 (GDF15) cytokine. RET plays a critical role in normal development as well as in various human tumors and developmental disorders. This review focuses on mechanisms of RET signaling and their alterations in human diseases.File in questo prodotto:
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