In this study, Fico, Beclin, and colleagues show that the long non-coding RNA T-UCstem1 is expressed in the forebrain neurogenic lineage generating interneurons for the postnatal olfactory bulb. Increased T-UCstem1 levels in neural stem cells induced progenitor proliferation at the expense of neuron production, whereas its downregulation caused the opposite effect. This regulatory function is mediated by its interaction with miR-9.
Long Non-coding RNA T-UCstem1 Controls Progenitor Proliferation and Neurogenesis in the Postnatal Mouse Olfactory Bulb through Interaction with miR-9 / Pascale, E.; Beclin, C.; Fiorenzano, A.; Andolfi, G.; Erni, A.; De Falco, S.; Minchiotti, G.; Cremer, H.; Fico, A.. - In: STEM CELL REPORTS. - ISSN 2213-6711. - 15:4(2020), pp. 836-844. [10.1016/j.stemcr.2020.08.009]
Long Non-coding RNA T-UCstem1 Controls Progenitor Proliferation and Neurogenesis in the Postnatal Mouse Olfactory Bulb through Interaction with miR-9
Pascale E.;Fiorenzano A.;Andolfi G.;
2020
Abstract
In this study, Fico, Beclin, and colleagues show that the long non-coding RNA T-UCstem1 is expressed in the forebrain neurogenic lineage generating interneurons for the postnatal olfactory bulb. Increased T-UCstem1 levels in neural stem cells induced progenitor proliferation at the expense of neuron production, whereas its downregulation caused the opposite effect. This regulatory function is mediated by its interaction with miR-9.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
