Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI.
Immune tolerance breakdown in inborn errors of immunity: Paving the way to novel therapeutic approaches / Giardino, Giuliana; Romano, Roberta; Lougaris, Vassilios; Castagnoli, Riccardo; Cillo, Francesca; Leonardi, Lucia; La Torre, Francesco; Soresina, Annarosa; Federici, Silvia; Cancrini, Caterina; Pacillo, Lucia; Toriello, Elisabetta; Cinicola, Bianca Laura; Corrente, Stefania; Volpi, Stefano; Marseglia, Gian Luigi; Pignata, Claudio; Cardinale, Fabio. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 251:(2023). [10.1016/j.clim.2023.109302]
Immune tolerance breakdown in inborn errors of immunity: Paving the way to novel therapeutic approaches
Giardino, Giuliana;Cillo, Francesca;Toriello, Elisabetta;Pignata, Claudio;
2023
Abstract
Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
