IRIS
D'ALESSIO, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 4.190
AS - Asia 3.983
EU - Europa 3.463
SA - Sud America 610
AF - Africa 105
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 5
Totale 12.363
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Nazione #
US - Stati Uniti d'America 4.001
SG - Singapore 2.325
RU - Federazione Russa 1.695
CN - Cina 809
BR - Brasile 499
IT - Italia 426
HK - Hong Kong 335
UA - Ucraina 284
VN - Vietnam 280
DE - Germania 223
FI - Finlandia 204
IE - Irlanda 192
CA - Canada 115
NL - Olanda 115
SE - Svezia 107
GB - Regno Unito 96
IN - India 62
MX - Messico 43
AR - Argentina 42
PL - Polonia 36
ZA - Sudafrica 33
BD - Bangladesh 29
CI - Costa d'Avorio 29
TR - Turchia 26
FR - Francia 22
JP - Giappone 21
ES - Italia 19
CO - Colombia 18
EC - Ecuador 18
ID - Indonesia 16
IQ - Iraq 12
CL - Cile 8
PK - Pakistan 8
SA - Arabia Saudita 8
UZ - Uzbekistan 8
PY - Paraguay 7
VE - Venezuela 7
EU - Europa 6
HN - Honduras 6
AT - Austria 5
BE - Belgio 5
KZ - Kazakistan 5
PE - Perù 5
SN - Senegal 5
TN - Tunisia 5
AE - Emirati Arabi Uniti 4
AL - Albania 4
AO - Angola 4
DO - Repubblica Dominicana 4
DZ - Algeria 4
EG - Egitto 4
JM - Giamaica 4
KE - Kenya 4
KR - Corea 4
LT - Lituania 4
MA - Marocco 4
AZ - Azerbaigian 3
EE - Estonia 3
ET - Etiopia 3
IR - Iran 3
KG - Kirghizistan 3
LU - Lussemburgo 3
OM - Oman 3
AU - Australia 2
BH - Bahrain 2
BO - Bolivia 2
BY - Bielorussia 2
BZ - Belize 2
CH - Svizzera 2
CR - Costa Rica 2
DK - Danimarca 2
HT - Haiti 2
JO - Giordania 2
LV - Lettonia 2
LY - Libia 2
MD - Moldavia 2
MK - Macedonia 2
NI - Nicaragua 2
PA - Panama 2
PG - Papua Nuova Guinea 2
PS - Palestinian Territory 2
RO - Romania 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
YT - Mayotte 2
AM - Armenia 1
BB - Barbados 1
BJ - Benin 1
BM - Bermuda 1
BS - Bahamas 1
BW - Botswana 1
CZ - Repubblica Ceca 1
DM - Dominica 1
GF - Guiana Francese 1
GM - Gambi 1
GN - Guinea 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
HU - Ungheria 1
Totale 12.344
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Città #
Singapore 958
Chandler 597
Moscow 431
Hong Kong 335
Jacksonville 276
Ashburn 263
Beijing 259
Millbury 211
Princeton 167
Santa Clara 148
Los Angeles 134
Ho Chi Minh City 107
Amsterdam 106
Naples 101
Buffalo 80
Nanjing 77
Ottawa 76
Wilmington 72
San Jose 71
Boston 69
New York 58
Hanoi 57
Munich 57
Hefei 50
Houston 49
Redondo Beach 48
The Dalles 47
São Paulo 44
Napoli 43
Woodbridge 39
Cagliari 36
Dallas 35
Warsaw 30
Dearborn 29
Seattle 29
Nanchang 27
Kronberg 25
Shenyang 25
Mexico City 24
Orange 24
Ann Arbor 23
Falls Church 23
Changsha 21
Norwalk 21
Tianjin 21
Tokyo 21
Boardman 20
Denver 20
Milan 20
Montreal 20
Rio de Janeiro 20
Turku 20
Brooklyn 19
Chicago 19
Poplar 18
Kunming 17
Stockholm 17
Johannesburg 16
Atlanta 15
Helsinki 15
London 15
Pune 15
Treviso 15
Chennai 14
Da Nang 14
Manchester 14
Belo Horizonte 13
San Francisco 13
Frankfurt am Main 12
Haiphong 12
Orem 12
Phoenix 12
Campinas 11
Düsseldorf 11
Hangzhou 11
Ankara 10
Guangzhou 10
Jinan 10
Jiaxing 9
Rome 9
Fortaleza 8
Guarulhos 8
Quito 8
Tashkent 8
Bologna 7
Curitiba 7
Hebei 7
Hải Dương 7
Mumbai 7
Ninh Bình 7
Porto Alegre 7
Salvador 7
Aracaju 6
Falkenstein 6
Hyderabad 6
Medellín 6
Redmond 6
Ribeirão Preto 6
Secaucus 6
Sorocaba 6
Totale 6.078
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Nome #
Ribonucleases and angiogenins from fish. 149
PHYSICO-CHEMICAL CHARACTERZATION OF GEODIN: A NEW B, G- CRYSTALLINE- TYPE PROTEIN SPONGE 147
A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish 141
CYTOSOLIC RNASE INHIBITOR ONLY AFFECTS RNASES WITH INTRINSIC CYTOTOXICITY. 134
ON THE THERMAL STABILITY OF THE TWO DIMERIC FORMS OF RIBONUCLEASE A. 121
Ribonucleasi Pancreatica e Seminale della Specie Bovina 117
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor 116
3D domain swapping and protein aggregation 116
The molecular basis for the production of an antitumor protein 116
Anti-ErbB2 human Immunoagents 113
Anti-ErbB2 human immunoagents 109
Immunotoxins and ImmunoRNases 109
3D domain swapping and supramolecular assembly 108
Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase 108
Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent. 106
Anti-ErbB2 immunoagents 106
Mechanisms of cardiotoxicity associated with ErbB2 inhibitors. 106
A novel fully human antitumour immunoRNase targeting ErbB2-positive tumours. 105
Human Antitumor RNases and ImmunoRNases 104
A dimeric mutant of human pancreas ribonuclease with selective antitumor action 104
Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors. 104
Protein engineering of ribonucleases 104
1H and 15N sequential assignment and secondary structure of the monomeric N67D mutant of bovine seminal ribonuclease 102
Full antitumor action of recombinant seminal ribonuclease depends on the removal of its N-terminal methionine 102
The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis 101
The singular case of seminal RNase, a dimer with two quaternary conformations, inspected with Trypsin as a conformational probe 101
Antitumor pancreatic-type RNases 101
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis 100
Anti-ErbB2 Human Immunoagents 99
Ribonucleases with angiogenic and bactericidal activities from the Atlantic salmon 99
Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin 98
A new mutein of RNase A with enhanced antitumor action 98
A Novel Human Anti-tumor Dimeric ImmunoRNase 97
Combinatorial experimental protocols for Erbicin-derived immunoagents and Herceptin 95
IMMUNORNASES AS ANTITUMOUR AGENTS 95
Effects of a human compact anti-ErbB2 antibody on prostate cancer 94
Bovine seminal ribonuclease, a problem protein 94
The antitumor action of seminal ribonuclease and its quaternary conformations 94
Bovine Seminal RNase: an atypical member of the ribonuclease superfamily 94
Human, Anti-ErbB2 Antitumor Immunoagents 92
Cardiotoxic effects, or lack thereof, of anti-ErbB2 immunoagents 92
Comparative proton NMR studies on bovine semen and pancreas ribonucleases. 91
A novel ErbB2 epitope targeted by human antitumor immunoagents 90
Site-directed mutagenesis induces domain swapping and fibril formation in human pancreatic ribonuclease 90
A new RNase-based immunoconjugate selectively cytotoxic for ErbB2-overexpressing cells. 89
A fully human antitumor immunoRNase selective for ErbB-2-positive carcinomas. 89
Binding of human immunoagents and Herceptin to the ErbB2 receptor 89
Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma. 89
Seminal RNAase and Other RISBASES 89
A NEW HUMAN ANTITUMOR IMMUNOREAGENT SPECIFIC FOR ERBB2 88
A NEW RNASE BASED IMMUNOCONJUGATE SELECTIVELY CYTOTOXIC FOR ERBB2-OVEREXPRESSING CELLS. 88
ESSENTIAL STATIONS IN THE INTRACELLULAR PATHWAYS OF CYTOTOXIC BOVINE SEMINAL RIBONUCLEASE 87
A novel method for detection of seleno-methionine incorporation in protein crystals via Raman microscopy 87
Muteins of pancreatic ribonuclease and uses thereof 87
Domain swapping and protein fibril assembly 87
Differential binding of human immunoagents and Herceptin to the ErbB2 receptor 87
The swapping of terminal arms in ribonucleases: comparison of the solution structure of monomeric bovine seminal and pancreatic ribonucleases 86
A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent 86
In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors. 86
Characterization of the angiogenic activity of zebrafish ribonucleases. 86
NOVEL HUMAN ANTI-ErbB2 IMMUNOAGENTS 85
Anticooperative Binding of Cytidine-2'-Phosphate to Ribonuclease BS-1 85
The success of the RNase scaffold in the advance of biosciences and in evolution 84
A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action. 83
Human mini-antibody cytotoxic for tumor cells which express the ErbB2 receptor 83
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor 82
A ROLE FOR THE INTERSUBUNIT DISULFIDES OF SEMINAL RNASE IN THE MECHANISM OF ITS ANTITUMOR ACTION. 81
A new RNase-based immunoconjugate selectively cytotoxic for ErbB2-overexpressing cells. 81
1H AND 15N SEQUENTIAL ASSIGNEMENT AND SECONDARY STRUCTURE OF THE MONOMERIC N76D MUTANT OF BOVINE SEMINAL RIBONUCLEASE. 81
DEGRADATION OF DOUBLE-STRANDED RNA BY HUMAN PANCREATIC RIBONUCLEASE: CRUCIAL ROLE OF NONCATALYTIC BASIC AMINO ACID RESIDUES. 80
Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease 80
Thermodynamic stability of five RNases from zebrafish (Danio rerio) 80
IL MECCANISMO DATTIVITÀ ANTITUMORALE DELLA RIBONUCLEASI SEMINALE 79
A DIMERIC MUTANT OF HUMAN PANCREATIC RIBONUCLEASE WITH SELECTIVE CYTOTOXICITY TOWARD MALIGNANT CELLS 79
X-ray diffraction studies of two dimeric variants of human pancreatic ribonuclease 79
Strategies for Protein Engineering of Ribonucleases with Farmacological Potentials 79
Un nuovo mutante della RNasi A dotato di attività antitumorale 79
Seminal RNase: a Unique Member of the Ribonuclease Superfamily 78
Investigating site-site interaction of BS-RNase by protein engineering 78
Temporal and spatial expression of RNases from zebrafish (Danio rerio). 77
Selective Deamidation of Ribonuclease A 77
RNAases and RISBASES 76
LA RIBONUCLEASI PANCREATICA UMANA: INTERAZIONI CON SUBSTRATI ED INIBITORI 75
Bull Semen RNAase Revisited 75
UN MODELLO SPERIMENTALE PER LO STUDIO DEL RUOLO DELLINIBITORE CITOSOLICO DELLE RIBONUCLEASI 74
THE EVOLUTION OF MONOMERIC AND OLIGOMERIC BETAGAMMA-TYPE CRYSTALLINS. FACTS AND HYPOTHESES. 74
Hints on the evolutionary design of a dimeric RNase with special bioactions 74
A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action 73
Engineering of Bovine Seminal Ribonuclease: Expression of the Secreted Recombinant Protein 71
A NEW HUMAN ANTITUMOR IMMUNOREAGENT SPECIFIC FOR ERBB2. 70
Site-Directed Alkylation and Site-Site Interactions in Bovine Seminal Ribonuclease 70
From immunotoxins to immunoRNases. 69
Dimeric Organization and Functional Properties of Seminal Ribonuclease: their Relationships with the Structure and Function of Pancreatic RNase 68
Engineering of Seminal RNAase: First Steps Towards the Construction of Chimaeric Ribonucleases 68
The role of electrostatic interactions in the antitumor activity of dimeric RNases 67
Struttura e Funzione della Ribonucleasi BS-1 67
The Determinants of the Dimeric Structure of Seminal Ribonuclease are Located in its N-Terminal Region 67
Co-operativity in Seminal Ribonuclease Function: Kinetic Studies 65
Relazioni tra la Struttura Quaternaria della Ribonucleasi BS-1 e la Non Equivalenza Funzionale dei Siti Catalitici 65
EVOLUTION OF OLIGOMERIC PROTEINS. THE UNUSUAL CASE OF A DIMERIC RIBONUCLEASE 64
Totale 9.084
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Categoria #
all - tutte 42.698
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.698
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021194 0 0 0 0 0 0 57 4 56 14 55 8
2021/2022950 16 1 4 9 1 36 12 34 202 51 185 399
2022/20231.226 192 109 37 148 139 141 6 116 172 106 45 15
2023/2024657 29 121 81 44 26 46 13 99 3 13 132 50
2024/20253.667 211 194 26 15 108 141 448 206 218 410 1.360 330
2025/20264.307 777 449 682 640 1.387 287 85 0 0 0 0 0
Totale 12.521