SUMMA, Vincenzo
SUMMA, Vincenzo
DIPARTIMENTO DI FARMACIA
Researches on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases
1994 Botta, ; Maurizio, ; Saladino, ; Raffaele, ; Gentile, ; Gabriella, ; Summa, V; Nicoletti, ; Rosario, ; Verri, ; Annalisa, ; Focher, ; Federico, ; Spadari, ; Silvio,
Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: The basis of the genotype 1b vs. 3a inhibitor potency shift
2010 Gallo, ; Mariana, ; Bottomley, ; Matthew, James; Pennestri, ; Matteo, ; Eliseo, ; Tommaso, ; Paci, ; Maurizio, ; Koch, ; Uwe, ; Bazzo, ; Renzo, ; Summa, V; Carfi, ; Andrea, ; Cicero, ; Daniel, O
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
2012 Rudd, ; M, T.; Mccauley, ; J, A.; Romano, ; J, J.; Butcher, ; J, W.; Bush, ; K, ; Mcintyre, ; C, J.; Nguyen, ; K, T.; Gilbert, ; K, F.; Lyle, ; T, A.; Holloway, ; M., K.; Wan, ; B-L, ; Vacca, ; J, P.; Summa, V; Harper, ; S, ; Rowley, ; M, ; Carroll, ; S, S.; Burlein, ; C, ; Dimuzio, ; J, M.; Gates, ; A, ; Graham, ; D, J.; Huang, ; Q, ; Ludmerer, ; S, W.; Mcclain, ; S, ; Mchale, ; C, ; Stahlhut, ; M, ; Fandozzi, ; C, ; Taylor, ; A, ; Trainor, ; N, ; Olsen, ; D, B.; Liverton, ; N, J.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants
2012 Summa, V; Steven, W Ludmerer; John, A McCauley; Christine, Fandozzi; Christine, Burlein; Giuliano, Claudio; Paul, J Coleman; Jillian, M DiMuzio; Marco, Ferrara; Marcello Di, Filippo; Adam, T Gates; Donald, J Graham; Steven, Harper; Daria, J Hazuda; Qian, Huang; Carolyn, Mchale; Edith, Monteagudo; Vincenzo, Pucci; Michael, Rowley; Michael, T Rudd; Aileen, Soriano; Mark, W Stahlhut; Joseph, P Vacca; David, B Olsen; Nigel, J Liverton; Steven, S Carroll
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors
2009 Donghi, ; Monica, ; Kinzel, ; Olaf, D.; Summa, V
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternization of a chiral center
2009 Nizi, ; Emanuela, ; Orsale, ; Maria, Vittoria; Crescenzi, ; Benedetta, ; Pescatore, ; Giovanna, ; Muraglia, ; Ester, ; Alfieri, ; Anna, ; Gardelli, ; Cristina, ; Spieser, ; Stephane, A. H.; Summa, V
Chiral Azole Derivatives. 2. Synthesis of Enantiomerically Pure 1-Alkylimidazoles
1995 Corelli, ; Federico, ; Summa, V; Brogi, ; Alessandra, ; Monteagudo, ; Edith, ; Botta, ; Maurizio,
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates; fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors
2008 Kinzel, ; Olaf, D.; Ball, ; Richard, G.; Donghi, ; Monica, ; Maguire, ; Courtney, K.; Muraglia, ; Ester, ; Pesci, ; Silvia, ; Rowley, ; Michael, ; Summa, V
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
2012 Di, Francesco; M., Emilia; Avolio, ; Salvatore, ; Pompei, ; Marco, ; Pesci, ; Silvia, ; Monteagudo, ; Edith, ; Pucci, ; Vincenzo, ; Giuliano, ; Claudio, ; Fiore, ; Fabrizio, ; Rowley, ; Michael, ; Summa, V
Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty
2018 Di Marino, S; Viceconte, N; Lembo, A; Summa, V; Tanzilli, G; Raparelli, V; Truscelli, G; Mangieri, E; Gaudio, C; Cicero, D O
Routes to HIV-integrase inhibitors: efficient synthesis of bicyclic pyrimidones by ring expansion or amination at a benzylic position
2009 Ferreira, ; Maria del Rosario, Rico; Cecere, ; Giuseppe, ; Pace, ; Paola, ; Summa, V
Phosphorous acid analogs of novel P2-P4 macrocycles as inhibitors of HCV-NS3 protease
2009 Pompei, ; Marco, ; Di, Francesco; Maria, Emilia; Koch, ; Uwe, ; Liverton, ; Nigel, J.; Summa, V
Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2-P4 Macrocycles
2009 Harper, ; S, ; Ferrara, ; M, ; Crescenzi, ; B, ; Pompei, ; M, ; Palumbi, ; M, C; Di, Muzio; J, M.; Donghi, ; M, ; Fiore, ; F, ; Koch, ; U, ; Liverton, ; N, J.; Pesci, ; S, ; Petrocchi, ; A, ; Rowley, ; M, ; Summa, V; Gardelli, ; C,
Binding of a Noncovalent Inhibitor Exploiting the S' region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor
2009 Gallo, ; Mariana, ; Pennestri, ; Matteo, ; Bottomley, ; Matthew, James; Barbato, ; Gaetano, ; Eliseo, ; Tommaso, ; Paci, ; Maurizio, ; Narjes, ; Frank, ; De, Francesco; Raffaele, ; Summa, V; Koch, ; Uwe, ; Bazzo, ; Renzo, ; Cicero, ; Daniel, O
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase
2004 Pace, ; Paola, ; Nizi, ; Emanuela, ; Pacini, ; Barbara, ; Pesci, ; Silvia, ; Matassa, ; Victor, ; De, Francesco; Raffaele, ; Altamura, ; Sergio, ; Summa, V
Advances in the development of macrocyclic inhibitors of hepatitis C virus NS3-4A protease
2010 Avolio, ; Salvatore, ; Summa, V
Inhibitors of hepatitis C virus NS3/4A: α-Ketoamide based macrocyclic inhibitors
2009 By:, Avolio; Salvatore, ; Robertson, ; Keith, ; Hernando, ; Jose Ignacio, Martin; Di, Muzio; Jillian, ; Summa, V
Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay
2010 Michelini, ; Zuleika, ; Galluzzo, ; Clementina, Maria; Negri, ; Donatella, R. M.; Leone, ; Pasqualina, ; Amici, ; Roberta, ; Bona, ; Roberta, ; Summa, V; Di, Santo; Roberto, ; Costi, ; Roberta, ; Pommier, ; Yves, ; Marchand, ; Christophe, ; Palmisano, ; Lucia, ; Vella, ; Stefano, ; Cara, ; Andrea,
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains
2018 Mori, ; Kovalenko, ; Malancona, ; Saladini, ; De, Forni; Pires, ; Humbert, ; Real, ; Botzanowski, ; Cianferani, ; Giannini, ; Dasso, Lang; M., C.; Cugia, ; Poddesu, ; Lori, ; Zazzi, ; Harper, ; Steven, ; Summa, V; Mely, ; Y, ; Botta,
4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species
2006 Summa, V; Petrocchi, ; Alessia, ; Matassa, ; Victor, G.; Gardelli, ; Cristina, ; Muraglia, ; Ester, ; Rowley, ; Michael, ; Paz, ; Odalys, Gonzalez; Laufer, ; Ralph, ; Monteagudo, ; Edith, ; Pace, ; Paola,
| Titolo | Tipologia | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|---|
| Researches on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases | 1.1 Articolo in rivista | 1994 | Botta, ; Maurizio, ; Saladino, ; Raffaele, ; Gentile, ; Gabriella, ; Summa, V; Nicoletti, ; Rosario, ; Verri, ; Annalisa, ; Focher, ; Federico, ; Spadari, ; Silvio, | |
| Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: The basis of the genotype 1b vs. 3a inhibitor potency shift | 1.1 Articolo in rivista | 2010 | Gallo, ; Mariana, ; Bottomley, ; Matthew, James; Pennestri, ; Matteo, ; Eliseo, ; Tommaso, ; Paci, ; Maurizio, ; Koch, ; Uwe, ; Bazzo, ; Renzo, ; Summa, V; Carfi, ; Andrea, ; Cicero, ; Daniel, O | |
| Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease | 1.1 Articolo in rivista | 2012 | Rudd, ; M, T.; Mccauley, ; J, A.; Romano, ; J, J.; Butcher, ; J, W.; Bush, ; K, ; Mcintyre, ; C, J.; Nguyen, ; K, T.; Gilbert, ; K, F.; Lyle, ; T, A.; Holloway, ; M., K.; Wan, ; B-L, ; Vacca, ; J, P.; Summa, V; Harper, ; S, ; Rowley, ; M, ; Carroll, ; S, S.; Burlein, ; C, ; Dimuzio, ; J, M.; Gates, ; A, ; Graham, ; D, J.; Huang, ; Q, ; Ludmerer, ; S, W.; Mcclain, ; S, ; Mchale, ; C, ; Stahlhut, ; M, ; Fandozzi, ; C, ; Taylor, ; A, ; Trainor, ; N, ; Olsen, ; D, B.; Liverton, ; N, J. | |
| MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants | 1.1 Articolo in rivista | 2012 | Summa, V; Steven, W Ludmerer; John, A McCauley; Christine, Fandozzi; Christine, Burlein; Giuliano, Claudio; Paul, J Coleman; Jillian, M DiMuzio; Marco, Ferrara; Marcello Di, Filippo; Adam, T Gates; Donald, J Graham; Steven, Harper; Daria, J Hazuda; Qian, Huang; Carolyn, Mchale; Edith, Monteagudo; Vincenzo, Pucci; Michael, Rowley; Michael, T Rudd; Aileen, Soriano; Mark, W Stahlhut; Joseph, P Vacca; David, B Olsen; Nigel, J Liverton; Steven, S Carroll | |
| 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors | 1.1 Articolo in rivista | 2009 | Donghi, ; Monica, ; Kinzel, ; Olaf, D.; Summa, V | |
| Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternization of a chiral center | 1.1 Articolo in rivista | 2009 | Nizi, ; Emanuela, ; Orsale, ; Maria, Vittoria; Crescenzi, ; Benedetta, ; Pescatore, ; Giovanna, ; Muraglia, ; Ester, ; Alfieri, ; Anna, ; Gardelli, ; Cristina, ; Spieser, ; Stephane, A. H.; Summa, V | |
| Chiral Azole Derivatives. 2. Synthesis of Enantiomerically Pure 1-Alkylimidazoles | 1.1 Articolo in rivista | 1995 | Corelli, ; Federico, ; Summa, V; Brogi, ; Alessandra, ; Monteagudo, ; Edith, ; Botta, ; Maurizio, | |
| 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates; fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors | 1.1 Articolo in rivista | 2008 | Kinzel, ; Olaf, D.; Ball, ; Richard, G.; Donghi, ; Monica, ; Maguire, ; Courtney, K.; Muraglia, ; Ester, ; Pesci, ; Silvia, ; Rowley, ; Michael, ; Summa, V | |
| Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase | 1.1 Articolo in rivista | 2012 | Di, Francesco; M., Emilia; Avolio, ; Salvatore, ; Pompei, ; Marco, ; Pesci, ; Silvia, ; Monteagudo, ; Edith, ; Pucci, ; Vincenzo, ; Giuliano, ; Claudio, ; Fiore, ; Fabrizio, ; Rowley, ; Michael, ; Summa, V | |
| Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty | 1.1 Articolo in rivista | 2018 | Di Marino, S; Viceconte, N; Lembo, A; Summa, V; Tanzilli, G; Raparelli, V; Truscelli, G; Mangieri, E; Gaudio, C; Cicero, D O | |
| Routes to HIV-integrase inhibitors: efficient synthesis of bicyclic pyrimidones by ring expansion or amination at a benzylic position | 1.1 Articolo in rivista | 2009 | Ferreira, ; Maria del Rosario, Rico; Cecere, ; Giuseppe, ; Pace, ; Paola, ; Summa, V | |
| Phosphorous acid analogs of novel P2-P4 macrocycles as inhibitors of HCV-NS3 protease | 1.1 Articolo in rivista | 2009 | Pompei, ; Marco, ; Di, Francesco; Maria, Emilia; Koch, ; Uwe, ; Liverton, ; Nigel, J.; Summa, V | |
| Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2-P4 Macrocycles | 1.1 Articolo in rivista | 2009 | Harper, ; S, ; Ferrara, ; M, ; Crescenzi, ; B, ; Pompei, ; M, ; Palumbi, ; M, C; Di, Muzio; J, M.; Donghi, ; M, ; Fiore, ; F, ; Koch, ; U, ; Liverton, ; N, J.; Pesci, ; S, ; Petrocchi, ; A, ; Rowley, ; M, ; Summa, V; Gardelli, ; C, | |
| Binding of a Noncovalent Inhibitor Exploiting the S' region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor | 1.1 Articolo in rivista | 2009 | Gallo, ; Mariana, ; Pennestri, ; Matteo, ; Bottomley, ; Matthew, James; Barbato, ; Gaetano, ; Eliseo, ; Tommaso, ; Paci, ; Maurizio, ; Narjes, ; Frank, ; De, Francesco; Raffaele, ; Summa, V; Koch, ; Uwe, ; Bazzo, ; Renzo, ; Cicero, ; Daniel, O | |
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase | 1.1 Articolo in rivista | 2004 | Pace, ; Paola, ; Nizi, ; Emanuela, ; Pacini, ; Barbara, ; Pesci, ; Silvia, ; Matassa, ; Victor, ; De, Francesco; Raffaele, ; Altamura, ; Sergio, ; Summa, V | |
| Advances in the development of macrocyclic inhibitors of hepatitis C virus NS3-4A protease | 1.1 Articolo in rivista | 2010 | Avolio, ; Salvatore, ; Summa, V | |
| Inhibitors of hepatitis C virus NS3/4A: α-Ketoamide based macrocyclic inhibitors | 1.1 Articolo in rivista | 2009 | By:, Avolio; Salvatore, ; Robertson, ; Keith, ; Hernando, ; Jose Ignacio, Martin; Di, Muzio; Jillian, ; Summa, V | |
| Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay | 1.1 Articolo in rivista | 2010 | Michelini, ; Zuleika, ; Galluzzo, ; Clementina, Maria; Negri, ; Donatella, R. M.; Leone, ; Pasqualina, ; Amici, ; Roberta, ; Bona, ; Roberta, ; Summa, V; Di, Santo; Roberto, ; Costi, ; Roberta, ; Pommier, ; Yves, ; Marchand, ; Christophe, ; Palmisano, ; Lucia, ; Vella, ; Stefano, ; Cara, ; Andrea, | |
| Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains | 1.1 Articolo in rivista | 2018 | Mori, ; Kovalenko, ; Malancona, ; Saladini, ; De, Forni; Pires, ; Humbert, ; Real, ; Botzanowski, ; Cianferani, ; Giannini, ; Dasso, Lang; M., C.; Cugia, ; Poddesu, ; Lori, ; Zazzi, ; Harper, ; Steven, ; Summa, V; Mely, ; Y, ; Botta, | |
| 4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species | 1.1 Articolo in rivista | 2006 | Summa, V; Petrocchi, ; Alessia, ; Matassa, ; Victor, G.; Gardelli, ; Cristina, ; Muraglia, ; Ester, ; Rowley, ; Michael, ; Paz, ; Odalys, Gonzalez; Laufer, ; Ralph, ; Monteagudo, ; Edith, ; Pace, ; Paola, |