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An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate is described. The scope of the synthesis regarding the introduction of substituents on the pyrido-fused ring is explored. © 2008 Elsevier Ltd. All rights reserved.

3-​Hydroxy-​4-​oxo-​4H-​pyrido[1,​2-​a]​pyrimidine-​2-​carboxylates; fast access to a heterocyclic scaffold for HIV-​1 integrase inhibitors / Kinzel, ; Olaf, D.; Ball, ; Richard, G.; Donghi, ; Monica, ; Maguire, ; Courtney, K.; Muraglia, ; Ester, ; Pesci, ; Silvia, ; Rowley, ; Michael, ; Summa, V. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 49:46(2008), pp. 6556-6558. [10.1016/j.tetlet.2008.09.010]

3-​Hydroxy-​4-​oxo-​4H-​pyrido[1,​2-​a]​pyrimidine-​2-​carboxylates; fast access to a heterocyclic scaffold for HIV-​1 integrase inhibitors

Summa V
2008

Abstract

An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate is described. The scope of the synthesis regarding the introduction of substituents on the pyrido-fused ring is explored. © 2008 Elsevier Ltd. All rights reserved.
2008
3-​Hydroxy-​4-​oxo-​4H-​pyrido[1,​2-​a]​pyrimidine-​2-​carboxylates; fast access to a heterocyclic scaffold for HIV-​1 integrase inhibitors / Kinzel, ; Olaf, D.; Ball, ; Richard, G.; Donghi, ; Monica, ; Maguire, ; Courtney, K.; Muraglia, ; Ester, ; Pesci, ; Silvia, ; Rowley, ; Michael, ; Summa, V. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 49:46(2008), pp. 6556-6558. [10.1016/j.tetlet.2008.09.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/772443
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