Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture / Santoro, Massimo; Melillo, ROSA MARINA; Fusco, Alfredo. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - STAMPA. - 155:5(2006), pp. 645-653. [10.1530/eje.1.02289]
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
SANTORO, MASSIMO;MELILLO, ROSA MARINA;FUSCO, ALFREDO
2006
Abstract
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
