The potential use of S-adenosyl-L-methionine (SAMe) as therapy for human porphyria cutanea tarda was investigated in an experimental model of hepatic porphyria - that is, chronic treatment of female rats with 0.2% hexachlorobenzene (HCB) in the diet. Administration of SAMe (25 mg/kg subcutaneously twice daily) during the last 15 days of HCB administration halved porphyrin accumulation in the liver but did not alter HCB-induced massive inhibition of uroporphyrinogen decarboxylase. Equally unaffected were inhibition of glutathione peroxidase and stimulation of lipid peroxide formation induced by HCB. Hypothetically, the beneficial effect of SAMe on hepatic prophyrin accumulation might be linked to modifications of the cellular availability of adenosine triphosphate
Protective effect of S-Adenosyl-L-Methionine in hepatic uroporphyria. Evaluation in an experimental model / Cantoni, L.; Budillon, G.; Cuomo, Rosario; Rodinò, S.; LE GRAZIE, G.; DI PADOVA, C.; Rizzardini, M.. - In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0036-5521. - STAMPA. - 25:10(1990), pp. 1034-1040. [10.3109/00365529008997631]
Protective effect of S-Adenosyl-L-Methionine in hepatic uroporphyria. Evaluation in an experimental model.
CUOMO, ROSARIO;
1990
Abstract
The potential use of S-adenosyl-L-methionine (SAMe) as therapy for human porphyria cutanea tarda was investigated in an experimental model of hepatic porphyria - that is, chronic treatment of female rats with 0.2% hexachlorobenzene (HCB) in the diet. Administration of SAMe (25 mg/kg subcutaneously twice daily) during the last 15 days of HCB administration halved porphyrin accumulation in the liver but did not alter HCB-induced massive inhibition of uroporphyrinogen decarboxylase. Equally unaffected were inhibition of glutathione peroxidase and stimulation of lipid peroxide formation induced by HCB. Hypothetically, the beneficial effect of SAMe on hepatic prophyrin accumulation might be linked to modifications of the cellular availability of adenosine triphosphateI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
