We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.
A Novel Super-Potent Neurokinin A Receptor Antagonist Containing Dehydroalanine / Lombardi, Angelina; B., Dagostino; Nastri, Flavia; L. D., Dandrea; A., Filippelli; M., Falciani; F., Rossi; Pavone, Vincenzo. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 8:10(1998), pp. 1153-1156. [10.1016/S0960-894X(98)00178-4]
A Novel Super-Potent Neurokinin A Receptor Antagonist Containing Dehydroalanine
LOMBARDI, ANGELINA;NASTRI, FLAVIA;PAVONE, VINCENZO
1998
Abstract
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
